Navigation Links
Selective Marker Found to Indicate Aggressive Form of Breast Cancer

Researchers have linked a structural protein called nestin to a particularly deadly form of breast cancer, identifying a new biomarker that could lead to earlier detection and better treatment.//

In the January 15 issue of Cancer Research, researchers from Dartmouth Medical School demonstrate that nestin could represent a selective biological marker for basal epithelial breast tumors, a highly aggressive cancer with similarities to mammary stem cells, the regenerative cells believed to be the site of breast cancer initiation.

'Patients with this type of breast cancer are at high risk for recurrence,' said James DiRenzo, Ph.D., assistant professor at Dartmouth Medical School. 'Ideally, a marker like nestin would enable clinicians to monitor these patients through frequent tests of a biomarker and, in doing so, detect the cancer before it has a chance to come back.'

Basal epithelial tumors lack important molecular targets such as the estrogen receptor, progesterone receptor and Her2. This not only makes positive diagnosis difficult, say researchers, but also eliminates several important lines of therapy, such as tamoxifen or Herceptin, that work well for other breast cancer subtypes.

'Currently, there is no direct means of determining if a breast cancer is a basal epithelial tumor – doctors only know for certain once the other forms of breast cancer are ruled out,' DiRenzo said. 'This type of breast cancer is generally difficult to manage, but several important studies have shown that it is more likely than other breast cancer subtypes to respond to certain types of therapy, which highlights the need for a definitive diagnostic marker.'

The basal epithelial breast cancer subtype represents 17 to 37 percent of all breast cancers and is more common in premenopausal African American women than in other demographic groups. Among breast cancers, this subtype is known to have an early age of onset and a very short
'"/>




Page: 1 2 3

Related medicine news :

1. Selective eating just an evolutionary trait?
2. New Study Questions Cannibalism As A Worldwide Selective Force
3. Govt to Pass Amendment to Curb Sex Selective Abortions: Ramadoss
4. Selective Marker Found to Indicate Aggressive Form of Breast Cancer
5. Wiping Out Memories Selectively, is Possible Now
6. Blood Marker Found To Predict Colon Cancer
7. Biochemical Markers Might Help Predict Heart Problems
8. Elevated Insulin Levels To Influence Levels Of Inflammatory Markers
9. Protein Markers for Identification of Brain Tumor
10. Protein Expression to Serve as Marker for Head and Neck Cancer
11. A New Marker For Type-2 Diabetes ?
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Selective Marker Found Indicate Aggressive Form Breast Cancer

(Date:9/30/2014)... of Maryland-led research team has been awarded a ... of Health (NIH) to develop new imaging technologies ... understanding of how large networks of neurons in ... knowledge will help researchers identify the precise interactions ... like decision-making and speaking, and alterations in these ...
(Date:9/30/2014)... 2014 EverStryke , the permanent match ... SurvivalLife.com along with a free book and class all about ... Michaels, prompting an investigative review. , “Joe Marshall of ... survival and preparation niche, and this product is an excellent ... and survival products that Joe offers on his website to ...
(Date:9/30/2014)... 30, 2014 Elevate , the latest ... better in and out of the gym by providing natural ... the attention of Shane Michaels, prompting an investigative review. ... the reason most people simply just don’t have the ability ... focused at work, getting the motivation to finish a project, ...
(Date:9/30/2014)... CA (PRWEB) September 30, 2014 ... providers in Turkey has gone up more than 79 ... The medical tourism company also reported total revenue tripled ... 2012. , The company’s professional strategy has allowed them ... — ultimately designed for patient comfort and privacy — ...
(Date:9/30/2014)... 30, 2014 Hospice & Palliative ... “In Celebration” gala, honoring three outstanding individuals for ... striving to provide extraordinary and dignified comfort, care ... serious or life-limiting illness. , The event was ... NY and recognized William (Bill) J. McGuinness, Director ...
Breaking Medicine News(10 mins):Health News:UMD receives inaugural BRAIN Initiative Award 2Health News:EverStryke: Review Exposes Joe Marshall’s Permanent Match Survival Product 2Health News:Elevate: Review Exposes Blue Star Nutraceutical’s Latest Supplement for Ultimate Brain Function, Focus, and Energy 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 3Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 4Health News:Hospice & Palliative Care of Westchester Honors Outstanding Individuals at Annual ‘In Celebration’ Gala 2
... New York, NY, August 6, 2009 Comprehensive health reform ... 13 million uninsured young adults ages 19-29 gain coverage, ... who now have coverage would not lose it, according ... coverage to all Americans through expansions in Medicaid and ...
... on medical tourism, exotic destinations , SATURDAY, Aug. 15 ... the U.S. government has a guidebook that could save ... and Prevention has released a new edition of ... as "The Yellow Book" for its distinctive cover, which ...
... , NEW YORK, Aug. 14 Healthcare may be on ... the price you pay at the pharmacy is actually getting the medicine ... to this report from Forest Laboratories at: http://inr.mediaseed.tv/oneClip _ ... Registered journalists can access video, audio, text, graphics and photos for ...
... , , , , ... Board: SNKTY), a Life Sciences company engaged in the research, development ... today announced revenues for its fiscal second quarter ended June 30, ... 31, 2009 and $691,000 reported in the comparable prior year period ...
... impact on cognition, study finds , FRIDAY, Aug. 14 ... difference in mental decline after the age of 70, ... the Aug. 1 issue of the American Journal ... background have an impact on cognitive functioning among the ...
... , Additional 28 New ... WASHINGTON, Aug. 14 Today, Secretary of Veterans Affairs Eric K. ... assistance in 28 additional communities across the country where the Department ... , , "VA is committed to providing high-quality ...
Cached Medicine News:Health News:Health reform proposals could help 13 million uninsured young adults gain coverage 2Health News:Health reform proposals could help 13 million uninsured young adults gain coverage 3Health News:International Travel Health Guidebook Gets Updated 2Health News:Senetek PLC Reports Second Quarter 2009 Financial Results 2Health News:Senetek PLC Reports Second Quarter 2009 Financial Results 3Health News:Senetek PLC Reports Second Quarter 2009 Financial Results 4Health News:Senetek PLC Reports Second Quarter 2009 Financial Results 5Health News:Senetek PLC Reports Second Quarter 2009 Financial Results 6Health News:Rich, Poor See Similar Declines in Old Age 2Health News:Secretary Shinseki Announces Expansion of Counseling for Combat Veterans 2
(Date:9/30/2014)... WEST ORANGE , N.J. and NEW BRUNSWICK, N.J., Sept. ... formal affiliation agreement that allows Kessler Foundation and ... to advance biomedical research, education and patient care ... , president and chief executive officer of Kessler ... of New Jersey Health Foundation. "The ...
(Date:9/30/2014)... , Sept. 30, 2014 The Eastern European ... established medical-device providers as well as new medical-device manufacturers ... while simultaneously looking at ways to reduce the cost ... distributors is one of the effective means to achieve ... distribution market in Eastern European and provides profiles of ...
(Date:9/30/2014)... Ariz. , Sept. 30, 2014 Passport ... North America , has launched FluFree.com, a website ... flu vaccinations. For 20 years, Passport Health ... including the flu. The launch of FluFree.com is designed ... vaccination and the number of people who actually chose ...
Breaking Medicine Technology:Kessler Foundation Partners with New Jersey Health Foundation To Start Innovative Companies To Change the Lives of People with Disabilities 2Medical Technologies Distributor Profiles in Eastern Europe 2Medical Technologies Distributor Profiles in Eastern Europe 3Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 2Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 3
... 26 BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ... Pharmaceuticals, Inc. (Huxley), which has rights to a ... the rare autoimmune disease Lambert Eaton Myasthenic Syndrome ... Products for Human Use of the European Medicines ...
... PINNACLE Network (TM) Links Thousands of Clinical ... Excellence , WASHINGTON, Oct. 26 The ... of the PINNACLE Network(TM), the first-ever registry-based cardiovascular ... each other and to the ACC,s National Cardiovascular ...
Cached Medicine Technology:BioMarin Acquires Huxley Pharmaceuticals, Inc. 2BioMarin Acquires Huxley Pharmaceuticals, Inc. 3BioMarin Acquires Huxley Pharmaceuticals, Inc. 4BioMarin Acquires Huxley Pharmaceuticals, Inc. 5BioMarin Acquires Huxley Pharmaceuticals, Inc. 6American College of Cardiology Launches the Nation's First Registry-Based Cardiovascular Practice Network 2American College of Cardiology Launches the Nation's First Registry-Based Cardiovascular Practice Network 3
Designed to fit a variety of 250 L and 300 ul multi-channel pipettors, this tip offers a secure fit and extra space for repeat pipetting....
... Finntip Filters are ideal for ... or for any work where ... are designed for pipetting DNA/RNA ... and other. For applications requiring ...
Hydrophobic PE filter without self-sealing additives, permits sample recovery after accidental over-pipetting. All filters are sterile (to USP, DAB, Ph.Eur. standards) and PCR clean (free from human ...
... Resistant Tips offer a safe alternative to ... designed for applications such as PCR(a), pipetting ... ART Tips are excellent for tissue culture, ... ART Tips prevent aerosol contaminants and liquids ...
Medicine Products: