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Secrets of the Heart's Signals

Natalia Trayanova's research team works on understanding the heart's natural electrical signaling process. The director of the Computational Cardiac Electrophysiology Lab, //she is a faculty member in the biomedical engineering department.

The subtle rhythms, pulses and patterns of the human heart have fascinated poets, lovers and scientists alike for millennia, yet the heart's deepest secrets remain tightly locked. Tulane biomechanical engineer Natalia Trayanova and her team may have the most incisive insight into the heart's electrical signals, with a three-dimensional virtual model that demonstrates cardiac activity from cellular to organ level.

Trayanova, director of Tulane's Computational Cardiac Electrophysiology Lab and professor of biomedical engineering, published an article in the March 2006 issue of Experimental Physiology describing the model's ability to predict the impact of electric shocks on tissues throughout the heart, a demonstration with implications for the world of heart-disease management.

Her research is dedicated to understanding the heart's natural electrical signaling process and how it interacts with electric shocks delivered by a defibrillator in order to improve the current anti-arrhythmia therapy.

Defibrillators provide an electric pulse that is intended to restore a heart's healthy rhythm. Prior to receiving implantable defibrillators, patients relied on pharmaceuticals with significant and often fatal side effects. Despite the relative improvement represented by current defibrillators, Trayanova says the pulse can cause people pain and discomfort.

In some patients, fear of receiving a pulse at an awkward moment, such as while driving, leads to additional anxiety. Correcting the problem is an issue of pulse energy and timing in relationship to the individual heart.

"Implanted defibrillators are a bit like using heavy explosives to open a door because you don't hav
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