Navigation Links
Secret Of Heartbeat Protein Unravelled

Scientists in the US have solved the structure of a critical piece of protein used to keep hearts beating that they say will help treat cardiac or neurological diseases//. Biologist Dale Mierke and other researchers at Brown University have solved the structure of synapse-associated protein 97 (SAP97) found in abundance in the heart and head, reports university website www.brown.edu.

This protein is believed to play a role in everything from cardiac contractions to memory creation.

SAP97 is found mainly in the central nervous system and is known as a "scaffolding" protein. In this role, it serves as a sort of tether, grabbing proteins inside the cell critical to nerve signalling and keeping them close to N-methyl-D-asparate (NMDA) receptors at the cell surface.

NMDA receptors help usher in a neurotransmitter called glutamate that is essential for learning and memory and also plays a role in drug addiction. A similar scaffolding mechanism is at work in the heart, where it affects basic functions, including the heartbeat.

SAP97 is a complex protein made up of five "domains" similar to a train comprising an engine and four boxcars. In their experiments, Mierke and other researchers focused on the engine.

This domain, known as PDZ1, is where the protein links to NMDA receptors. The team used high-resolution nuclear magnetic resonance spectroscopy to solve the structure of PDZ1, as well as a small portion of the receptor to which it binds.

Mierke said knowing how a piece of SAP97 is built is an important step. Now that part of the protein's structure is solved, scientists can create a molecule to disable it. That, in turn, will allow them to fully understand SAP97's role in the body.

And that will point drug makers to targets for developing new ways to treat cardiac or neurological diseases, he said.

Indo-Asian News Service


'"/>




Page: 1

Related medicine news :

1. Dietary phytonutrients – Secret for the good food to taste ba
2. Secret behind Babies soft skin
3. Secret Of Heart Failure Revealed
4. Critically Ill Patients More At Risk Of Infection If Glucose Is Present In Their Lung Secretions
5. Protein Secreted By Worm Eggs Holds Key To Anti-inflammatory Therapy
6. New Procedure Reveals the Secrets of the Brain
7. Scientists Discover Secret Of Curly Hair
8. Frog Secretions Could Be Used To Ward Off Mosquitoes
9. U.S. HSS Secretary Talks About Management of Bird Flu Pandemic
10. Secret behind Human To Human Transmission of Bird Flu Revealed
11. The Secret Behind Extension of Earthly Life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... ... May 26, 2017 , ... On May 24, the Congressional Budget Office ... U.S. House on May 4, would result in 23 million Americans losing their health ... the 2010 Patient Protection and Affordable Care Act (ACA). , “It is clear ...
(Date:5/26/2017)... ... May 26, 2017 , ... Rob Lowe acts as host and ... the series is on hiking in American. Viewers can reconnect with America as it ... of hiking. , Many consumers have looked for an inventive new place for a ...
(Date:5/26/2017)... ... May 26, 2017 , ... Centennial-based BluSky ... proceeds from its 14th Annual Clays for Kids fundraiser, to be held Friday, ... Colorado. , As part of BluSky’s partnership with The Adoption Exchange, BluSky ...
(Date:5/24/2017)... ... 2017 , ... Last month, representatives from Rendina Healthcare Real ... officials to celebrate the grand opening of the 87,000 square foot medical office/ICU ... its ongoing relationship with RWJBarnabas Health, New Jersey’s largest health system. Two years ...
(Date:5/24/2017)... ... May 24, 2017 , ... NucleusHealth ™, ... has received U.S. Food and Drug Administration (FDA) 510(k) clearance for ... secure cloud platform for medical image management. At the core is patented streaming ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... May 15, 2017 Enterin Inc., a privately-held CNS ... developing novel compounds to treat Parkinson,s disease (PD), has enrolled ... a Phase 1/2a randomized, controlled, multicenter study involving patients with ... enroll 50 patients over a 9-to-12-month period. The first stage ... patients with PD. Participating sites include Denver ...
(Date:5/11/2017)... , May 11, 2017  Thornhill Research Inc. ... been awarded an $8,049,024 USD five-year, firm-fixed-priced, indefinite-quantity/indefinite-delivery ... the Canadian Commercial Corporation (CCC) ( Ottawa, ... Systems to administer general anesthesia to patients requiring ... "The US Marine Corps have been a ...
(Date:5/10/2017)... May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of the ... based on extensive data analysis from GHI,s hospitals database ... database for the region. The GHI database covers 86% of ... more than 130 data points for each institution in key ...
Breaking Medicine Technology: