Navigation Links
Secret Of Heartbeat Protein Unravelled

Scientists in the US have solved the structure of a critical piece of protein used to keep hearts beating that they say will help treat cardiac or neurological diseases//. Biologist Dale Mierke and other researchers at Brown University have solved the structure of synapse-associated protein 97 (SAP97) found in abundance in the heart and head, reports university website www.brown.edu.

This protein is believed to play a role in everything from cardiac contractions to memory creation.

SAP97 is found mainly in the central nervous system and is known as a "scaffolding" protein. In this role, it serves as a sort of tether, grabbing proteins inside the cell critical to nerve signalling and keeping them close to N-methyl-D-asparate (NMDA) receptors at the cell surface.

NMDA receptors help usher in a neurotransmitter called glutamate that is essential for learning and memory and also plays a role in drug addiction. A similar scaffolding mechanism is at work in the heart, where it affects basic functions, including the heartbeat.

SAP97 is a complex protein made up of five "domains" similar to a train comprising an engine and four boxcars. In their experiments, Mierke and other researchers focused on the engine.

This domain, known as PDZ1, is where the protein links to NMDA receptors. The team used high-resolution nuclear magnetic resonance spectroscopy to solve the structure of PDZ1, as well as a small portion of the receptor to which it binds.

Mierke said knowing how a piece of SAP97 is built is an important step. Now that part of the protein's structure is solved, scientists can create a molecule to disable it. That, in turn, will allow them to fully understand SAP97's role in the body.

And that will point drug makers to targets for developing new ways to treat cardiac or neurological diseases, he said.

Indo-Asian News Service


'"/>




Page: 1

Related medicine news :

1. Dietary phytonutrients – Secret for the good food to taste ba
2. Secret behind Babies soft skin
3. Secret Of Heart Failure Revealed
4. Critically Ill Patients More At Risk Of Infection If Glucose Is Present In Their Lung Secretions
5. Protein Secreted By Worm Eggs Holds Key To Anti-inflammatory Therapy
6. New Procedure Reveals the Secrets of the Brain
7. Scientists Discover Secret Of Curly Hair
8. Frog Secretions Could Be Used To Ward Off Mosquitoes
9. U.S. HSS Secretary Talks About Management of Bird Flu Pandemic
10. Secret behind Human To Human Transmission of Bird Flu Revealed
11. The Secret Behind Extension of Earthly Life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating ... many ways they remain in the eye of the beholder, according to experts who ... of The American Journal of Managed Care. For the full issue, click here ...
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... Ill. and INDIANAPOLIS , ... students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is ... 2016 scholarship winners, announced today online at www.diabetesscholars.org ... let type 1 diabetes stand in the way of ... has supported the Foundation,s scholarship program since 2012, and ...
Breaking Medicine Technology: