Navigation Links
Secret Of Heartbeat Protein Unravelled

Scientists in the US have solved the structure of a critical piece of protein used to keep hearts beating that they say will help treat cardiac or neurological diseases//. Biologist Dale Mierke and other researchers at Brown University have solved the structure of synapse-associated protein 97 (SAP97) found in abundance in the heart and head, reports university website www.brown.edu.

This protein is believed to play a role in everything from cardiac contractions to memory creation.

SAP97 is found mainly in the central nervous system and is known as a "scaffolding" protein. In this role, it serves as a sort of tether, grabbing proteins inside the cell critical to nerve signalling and keeping them close to N-methyl-D-asparate (NMDA) receptors at the cell surface.

NMDA receptors help usher in a neurotransmitter called glutamate that is essential for learning and memory and also plays a role in drug addiction. A similar scaffolding mechanism is at work in the heart, where it affects basic functions, including the heartbeat.

SAP97 is a complex protein made up of five "domains" similar to a train comprising an engine and four boxcars. In their experiments, Mierke and other researchers focused on the engine.

This domain, known as PDZ1, is where the protein links to NMDA receptors. The team used high-resolution nuclear magnetic resonance spectroscopy to solve the structure of PDZ1, as well as a small portion of the receptor to which it binds.

Mierke said knowing how a piece of SAP97 is built is an important step. Now that part of the protein's structure is solved, scientists can create a molecule to disable it. That, in turn, will allow them to fully understand SAP97's role in the body.

And that will point drug makers to targets for developing new ways to treat cardiac or neurological diseases, he said.

Indo-Asian News Service


'"/>




Page: 1

Related medicine news :

1. Dietary phytonutrients – Secret for the good food to taste ba
2. Secret behind Babies soft skin
3. Secret Of Heart Failure Revealed
4. Critically Ill Patients More At Risk Of Infection If Glucose Is Present In Their Lung Secretions
5. Protein Secreted By Worm Eggs Holds Key To Anti-inflammatory Therapy
6. New Procedure Reveals the Secrets of the Brain
7. Scientists Discover Secret Of Curly Hair
8. Frog Secretions Could Be Used To Ward Off Mosquitoes
9. U.S. HSS Secretary Talks About Management of Bird Flu Pandemic
10. Secret behind Human To Human Transmission of Bird Flu Revealed
11. The Secret Behind Extension of Earthly Life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2016)... ... May 26, 2016 , ... Dr. James Maisel ... Blindness, Long Island Chapter on June 4, 2016, 1:30-3:30 pm at the Farmingdale ... of Retina Group of New York , is a Board Certified ophthalmologist ...
(Date:5/26/2016)... ... 26, 2016 , ... Leadership of Life Science Logistics (LSL), ... has earned its ISO 13485 certification, indicating the company’s quality control system for ... policies associated with ISO quality standard 13485. , BSI Group America, Inc., ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... offering campers a multitude of activities from daily practices, arts & crafts, discussions, ... Camp Directors Amber East-D’Anna and Christy Evans have combined backgrounds in kids’ yoga, ...
(Date:5/26/2016)... ... 2016 , ... Power Systems, a leading developer and supplier ... Course in Stoughton, Massachusetts. The course was led by Power Systems’ Education Coordinator, ... interactive course to qualify participants as certified PowerWave trainers. , PowerWave is ...
(Date:5/26/2016)... ... May 26, 2016 , ... A health conscious snack that doesn't sacrifice ... has ignited an undeniable buzz in the protein product community by offering an ... doughnut.  These doughnuts are packed with 11 grams of protein and made from a ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 25,2016 FDA 510(k) clearance ... platform for urological and surgical applications ... of Cellvizio®, the multidisciplinary confocal laser endomicroscopy (CLE) ... the US with the 12 th 510(k) ... (FDA). This new FDA clearance covers Confocal Miniprobes ...
(Date:5/25/2016)... Deutschland und GERMANTOWN, Maryland , ... Zusammenarbeit mit Therawis bedient dringenden ...   QIAGEN N.V. (NASDAQ: ... bekannt, eine Lizenz- und Entwicklungsvereinbarung mit Therawis Diagnostics ... die Onkologie eingegangen zu sein. Ein erstes Projekt ...
(Date:5/25/2016)... 2016  Zymo Research Corp. announced today the ... materials that help researchers obtain the most accurate ... The rapid growth of the study of microbiomes ... standard methods to improve the reproducibility and quality ... at every step of the measurement process including ...
Breaking Medicine Technology: