Navigation Links
Scientists found ancient Human Germ Killer

A substance that scientists created using information taken from a monkey gene ``dramatically protected'' human cells from the AIDS virus in a laboratory experiment. The researchers believe the substance, which they call ``retrocyclin,'' was once produced naturally in human cells, but was lost to humans because of an ancient mutation.

Alexander Cole, a scientist at the University of California, Los Angeles, medical school, said he and other researchers// were led to the mutated human gene for an HIV-inhibiting compound by a sort of natural antibiotic found in the bone marrow of rhesus monkeys. The monkey substance was designated RTD-1.

Such naturally occurring germ fighters, known as ``defensins,'' are believed to have evolved tens of millions of years ago, Cole said, before birds separated from their reptile ancestors. They inhibit not only viruses but bacterial diseases as well. Although human beings have a variety of defensins, the fact that HIV is almost always fatal suggests that none exists for that virus.

Although it is not known if the monkey defensin is the reason these animals can be infected with AIDS-like viruses without becoming ill, the UCLA group became interested in the fact that there appeared to be no comparable human defensin. By scanning the human genome, they found a place where the molecular sequences was nearly 90 percent identical to the monkey gene for RTD-1.

However, inside the human gene was a mutation that prevented it from working, as if an extra, meaningless chain of letters had been inserted at the middle of a long word. Using chemical methods, the UCLA group traced the sequence of the human gene as if the extra letters weren't there and patterned the resulting substance after the monkey RTD-1. These techniques allowed them not only to assemble the chain-like molecule but also to bend it into a circle, then ``fold'' the circle.

Cole said he believes the result is identical to the ancestral human defensin, the one that would have occurred naturally before the mutation appeared. Next they added it to human cell cultures in a laboratory dish and exposed the cells to HIV. The virus was ``dramatically'' inhibited, they reported.

``I have to emphasize that these things are done in cell culture,'' Cole said last week. ``We're a long way from putting these things into humans. We are not even ready to do animal studies. We are looking forward to that in the near future.'' He added: ``I truly believe this molecule has a lot of promise.''


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists locate key hormone involved in appetite control
3. Scientists open the book of life
4. Scientists review SARS
5. Scientists crack dengue fever puzzle
6. Scientists push to lower hidden sodium in food
7. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
8. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
9. Scientists reveal the secrets of sarcasm
10. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
11. Scientists Warn Against Food Borne Illnesses
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... Guide to ... , No matter on which side of the Atlantic devicemakers do business, ... regulations they have to follow. , In addition to the full text of the ...
(Date:6/28/2017)... ... June 28, 2017 , ... Anyone with a remote control has seen the never-ending twists ... you the flipper will get rich in no time. But what about the buyers ... get for the buyer of a flipped house. An email recently sent to Gary ...
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... David B. Sosin, a founding ... Illinois, took over the post of 2nd Vice President for the Illinois State Bar ... installed as the ISBA’s 3rd Vice President in 2016 following a state-wide election and served ...
(Date:6/28/2017)... ... ... American Farmer proudly announces the participation of Pure Line Seeds, Inc (Pure ... broadcast fourth quarter 2017. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , Founded ... As demand grew, the small company located in Moscow, Idaho extended its sales from ...
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... ... ZEON) is pleased to announce that a two year study conducted by the ... Bromley Creek zeolite was successful in remediating potash brine-impacted groundwater. As a part ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... CALABASAS, Calif. , June 14, 2017 ... with the City of Fremont ... chain of the bio-pharma industry in California ... sharing technology, enabling executive networking, and fostering workforce development. ... the development and growth of start-ups, as well as ...
(Date:6/11/2017)... , June 10, 2017  Eli Lilly and Company (NYSE: ... three Phase 3 studies of galcanezumab, an investigational treatment ... late-breaking data on several key secondary endpoints for galcanezumab ... from these studies (EVOLVE-1, EVOLVE-2 and REGAIN) will be ... scientific meeting in Boston . ...
(Date:6/8/2017)... MAITLAND, Fla. , June 8, 2017  Less ... ransomware attack that hit more than 200,000 companies, including hospital ... is being heralded as one of the largest online ... technology in the healthcare market, it is imperative that ... can protect their data from this — and many ...
Breaking Medicine Technology: