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Scientists crack dengue fever puzzle

The discovery could hamper efforts to find an effective dengue vaccine. The risk, is that if the vaccine does not "hit" all four types of the virus, the vaccine may end up mimicking a second natural infection. For example, the vaccine may "prime" the immune system to attack only one or two types, leaving the patient with increased susceptibility to other types.

According to researchers, this danger was first identified after the development in the 1960s of a vaccine to the common respiratory syncytial virus "that made the natural disease worse." After vaccination with a harmless, inactivated form of the virus, children who were subsequently infected with respiratory syncytial virus -- the leading cause of lower respiratory tract infections in children -- suffered more severe lung symptoms than did unvaccinated children.
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