Navigation Links
Scientists Use Saliva's 'diagnostic Alphabets' to Diagnose Disease

Today, during the 85th General Session of the International Association for Dental Research, scientists are reporting that the use of saliva for clinical //detection of major human diseases is only a few years away. Intense research is ongoing to discover diagnostic saliva biomarkers. A necessary prerequisite is to know, in a comprehensive manner, the informative biomarkers in saliva: the diagnostic alphabets. Like languages, which are synthesized from a foundation of alphabets, there are multiple diagnostic languages and thus diagnostic alphabets in saliva. The salivary proteome and the salivary transcriptome are two diagnostic alphabets that are ready for translational and clinical applications.

The human salivary proteome is a consortium effort by three National Institute of Dental and Craniofacial Research-supported research groups (Scripps/Rochester; UCSF, and UCLA), leading to the identification of over 1,500 proteins in saliva. The salivary transcriptome revealed ~3,000 mRNA species in saliva, of which 185 are common among all healthy subjects examined.

Using the salivary proteome and transcriptome as diagnostic alphabets to search for diagnostic signatures, the investigators have found five salivary proteins and four salivary RNA to be highly discriminatory for oral cancer (>90% clinical accuracy). They have also examined the saliva from patients with the autoimmune disease Sjogren’s Syndrome, and have found a small subset of the salivary proteome and transcriptome to be highly discriminatory for this disease.


Page: 1

Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:

(Date:11/24/2015)... ... November 24, 2015 , ... Dr. Todd S. Afferica, a noted general ... many of his patients. Dr. Afferica now uses the BIOLASE WaterLase iPlus 2.0™ in ... time the doctor uses other traditional cutting tools, such as the scalpel and high-speed ...
(Date:11/24/2015)... ... 24, 2015 , ... ThirdLove, the fast-growing bra company that ... offering 40% off select bras and underwear styles, now through Saturday, November 28th. ... technology and the latest fashion, quickly becoming the next generation of luxury bras. ...
(Date:11/24/2015)... ... November 24, 2015 , ... The hospitals and ... several aspects of orthopedic care. They have received recognition for excellence from various ... care. , Becker's Hospital Review selected hospitals for inclusion based on national ...
(Date:11/24/2015)... ... November 24, 2015 , ... Brillouin Energy Corp. ... is the developer of renewable energy technologies capable of producing commercially useful amounts ... today that its WET™ and HHT™ Boiler System reactor core modules were presented ...
(Date:11/24/2015)... ... November 24, 2015 , ... The American Association of Poison ... poison centers through donations on Tuesday, Dec. 1, 2015. Since 2012, the Tuesday ... inspires people to collaborate in improving their local communities and help give back ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... leader in LCD screen protection and glare-elimination technology, is providing a vital solution to health care ... electronic documentation system. Photo - ... ... ... A study in 2013 by the National Institutes of Health found that ...
(Date:11/24/2015)...   Renowned UAE nutritionist ... advice and insights on supplements and healthy diet ing ... of Dubai residents are not consuming enough fruits ... femMED launches comprehensive solutions for women , s most common ... are not consuming enough to keep themselves healthy. A local expert addressed how ...
(Date:11/24/2015)... BRISTOL, Pa. , Nov. 24, 2015 /PRNewswire/ ... primarily for the medical research, clinical diagnostic and ... Kord-Valmark, a leading manufacturer of quality petri dishes. ... to offer clients a platform of products that ... and manufactured with the highest quality.  ...
Breaking Medicine Technology: