Navigation Links
Scientists Tout New Prostate Cancer Test

Oregon scientists say a simple test can identify men at high risk of life-threatening prostate cancer even after a biopsy finds no signs of it//. The key, researchers say, is "PSA density," which compares the size of a man's prostate with his levels of a cancer-related protein called prostate-specific antigen.

Men with the highest PSA densities were much more likely to later be diagnosed with aggressive cancers than men with lower scores in an Oregon study, even though both groups had clean prostate biopsies.

If it survives scientific review, it could help save the lives of men with serious cancers and avoid repeated biopsies in others.

"It's that 1-in-10 men that do have a life-threatening cancer that we wanted to identify," said Dr. Mark Garzotto, an Oregon Health & Science University Cancer Institute researcher, who recently presented the study at a cancer conference in Florida.

Prostate cancer will kill about 27,000 U.S. men this year. Doctors usually check for tumors with a prostate biopsy, which uses needles to gather cells from the gland.

More than a million U.S. men get prostate biopsies each year. The tests find more than 200,000 tumors, meaning many cancer-free men get unneeded biopsies.

Studies estimate that the test fails to find the tumor in 20 percent to 33 percent of men who have one, usually because the needles sample only bits of the gland.

"With less than 1 percent of the prostate sampled, we're trying to get the pathologist to tell us if the guy has cancer or not, which is an impossible task," said Garzotto. So doctors recommend second biopsies a few months after a clean test.

To narrow the need for repeat tests, Garzotto and co-workers studied 511 patients at the Veterans Affairs Medical Center, where he works. All the men had clear initial prostate biopsies. But 112 were later found to have cancer, 52 of them aggressive tumors that can be deadly.

The scientists found that "PSA density, by itself, was the best discriminator between guys in the high-risk group and the guys in the low-risk group," Garzotto said.

By 2 years after their clean biopsy, 23 percent of the men in the high-risk group had aggressive cancer compared with 4 percent of low-risk men, Garzotto said.

At four years, the rate was 36 percent in the high-risk group and 9 percent in the other.

"I feel more comfortable now about recommending repeat biopsies to this (high-risk) group," he said.

Another simple test may identify which men with advanced prostate cancer have the worst outlook, according to a different OHSU study presented at the Florida conference.

Dr. Tomasz Beer found that among men with advanced cancer, those with the highest level of C-reactive protein died significantly sooner than men with lower levels.

C-reactive protein is a sign of inflammation, which doctors increasingly think is "associated with cancer progression and cancer resistance to treatment," Beer said.

Source-Bio-Bio Technology
'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/29/2016)... ... April 30, 2016 , ... World Patent Marketing ... Up Springboard, an automotive invention that improves the storage features of a pick ... billion," says Scott Cooper, CEO and Creative Director of World Patent Marketing. "Over ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... , announces the addition Onnit brand Alpha BRAIN and New Mood Daily-Stress Formula ... brain and mood optimization products to the store is just one more way ...
(Date:4/29/2016)... ... April 29, 2016 , ... The White House announced ... loans, more information about their loan terms and accounts, and more protections for ... including federal and private loans, has reached $1.3 trillion, with 43 million Americans ...
(Date:4/29/2016)... ... April 29, 2016 , ... The Wharton ... $30,000 Perlman Grand Prize of the 2016 Wharton Business Plan Competition —as ... People’s Choice Award, and the Committee Award for Most ‘Wow Factor,’ making them ...
(Date:4/29/2016)... ... April 29, 2016 , ... Dr. Robert Mondavi, one of the ... smiles. Cosmetic dentistry is a fast-growing field as more patients are discovering the many ... learn more about the options currently available to them and which ones might work ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... Oasmia Pharmaceutical AB (NASDAQ: ... new generation of drugs within human and veterinary ... Paclical/Apealea in the Phase III study that included ... cancer. These preliminary results showed non-inferiority between the ... versus Taxol in combination with carboplatin. In fact, ...
(Date:4/27/2016)... At the Sachs CEO forum ... Phase 2 clinical study of its lead drug candidate, ... implantation (CI) surgery. This large, placebo-controlled, double-blind, phase 2 ... and France . STR001 ... time of surgery. "Despite advances in cochlear implant technology, ...
(Date:4/26/2016)... April 26, 2016 US demand for ... expand 4.9 percent annually to $27.6 billion in ... facilities to decrease rates of healthcare-associated infections (HAIs) ... equipment, and services.  Although declining, the overall rate ... targeted levels set by the CDC.  Recent statistics ...
Breaking Medicine Technology: