Navigation Links
Scientists Tout New Prostate Cancer Test

Oregon scientists say a simple test can identify men at high risk of life-threatening prostate cancer even after a biopsy finds no signs of it//. The key, researchers say, is "PSA density," which compares the size of a man's prostate with his levels of a cancer-related protein called prostate-specific antigen.

Men with the highest PSA densities were much more likely to later be diagnosed with aggressive cancers than men with lower scores in an Oregon study, even though both groups had clean prostate biopsies.

If it survives scientific review, it could help save the lives of men with serious cancers and avoid repeated biopsies in others.

"It's that 1-in-10 men that do have a life-threatening cancer that we wanted to identify," said Dr. Mark Garzotto, an Oregon Health & Science University Cancer Institute researcher, who recently presented the study at a cancer conference in Florida.

Prostate cancer will kill about 27,000 U.S. men this year. Doctors usually check for tumors with a prostate biopsy, which uses needles to gather cells from the gland.

More than a million U.S. men get prostate biopsies each year. The tests find more than 200,000 tumors, meaning many cancer-free men get unneeded biopsies.

Studies estimate that the test fails to find the tumor in 20 percent to 33 percent of men who have one, usually because the needles sample only bits of the gland.

"With less than 1 percent of the prostate sampled, we're trying to get the pathologist to tell us if the guy has cancer or not, which is an impossible task," said Garzotto. So doctors recommend second biopsies a few months after a clean test.

To narrow the need for repeat tests, Garzotto and co-workers studied 511 patients at the Veterans Affairs Medical Center, where he works. All the men had clear initial prostate biopsies. But 112 were later found to have cancer, 52 of them aggressive tumors that can be deadly.

The scientists found that "PSA density, by itself, was the best discriminator between guys in the high-risk group and the guys in the low-risk group," Garzotto said.

By 2 years after their clean biopsy, 23 percent of the men in the high-risk group had aggressive cancer compared with 4 percent of low-risk men, Garzotto said.

At four years, the rate was 36 percent in the high-risk group and 9 percent in the other.

"I feel more comfortable now about recommending repeat biopsies to this (high-risk) group," he said.

Another simple test may identify which men with advanced prostate cancer have the worst outlook, according to a different OHSU study presented at the Florida conference.

Dr. Tomasz Beer found that among men with advanced cancer, those with the highest level of C-reactive protein died significantly sooner than men with lower levels.

C-reactive protein is a sign of inflammation, which doctors increasingly think is "associated with cancer progression and cancer resistance to treatment," Beer said.

Source-Bio-Bio Technology
'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2016)... Petersburg, Fla. (PRWEB) , ... December 05, 2016 , ... ... concussions have on the growing brains of young athletes. Over the course of three ... the head through unique mouth guards. The mouth guards, equipped with special sensors, will ...
(Date:12/5/2016)... NY (PRWEB) , ... December 05, 2016 , ... ... to use a patent-pending blend of L-Citrulline and glutathione to enhance production of ... a combination that studies have shown to produce NO twice as effectively and ...
(Date:12/5/2016)... ... December 05, 2016 , ... Eating disorders ... goal of Castlewood Treatment Centers has always been to promote the power of ... people as possible. In that spirit, Castlewood has announced two new hires, both ...
(Date:12/5/2016)... ... December 05, 2016 , ... U.S. Apple Association (USApple) ... part of the second annual Apples for Education: Buy an Apple, Help a ... providing healthy food for students to take home to their families; solar technology to ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... Partners ("GPP") portfolio company, today announced it has acquired the assets of ... was previously a subsidiary of Chiltern International and focuses on clinical trial ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... India , December 5, 2016 According ... by Treatment modalities (Chondrocyte Transplantation, Growth Factor Technology, Tissue Scaffolds, Cell-free ... published by MarketsandMarkets, the market is projected to reach USD 779.8 ... a CAGR of 13.5% during the forecast period of 2016 to ... ...
(Date:12/5/2016)... and PUNE, India , December 5, ... by Allied Market Research, titled, "Global Cancer Biomarkers Market - ... of cancer biomarkers market is projected to reach $15,737 million ... of 13.3% from 2016 to 2022. Omic technologies segment accounted ... and is expected to maintain its dominance during the forecast ...
(Date:12/5/2016)...  CVS Health, the nation,s largest pharmacy innovation company, ... of 100 percent on the Corporate Equality Index (CEI) ... annual national benchmarking survey and report on corporate policies ... Human Rights Campaign Foundation. "Our company,s ... customers and suppliers bring to CVS Health," said ...
Breaking Medicine Technology: