Navigation Links
Scientists Review Loeys-Dietz Syndrome in the Largest Ever Study to date

of the William S. Smilow Center for Marfan Syndrome Research at Johns Hopkins, professor in the McKusick-Nathans Institute of Genetic Medicine, and a Howard Hughes Medical Institute investigator, "Distinguishing these conditions is essential in many ways. For example, when compared to Marfan syndrome, Loeys-Dietz patients are at high risk of rupturing their blood vessels at smaller dimensions, at a younger age, and in a wider distribution throughout the body. They are also at a much greater risk of tear or rupture of blood vessels or the uterus during pregnancy. When compared to people with vascular Ehlers-Danlos syndrome, patients with Loeys-Dietz syndrome do much better with cardiovascular surgery, highlighting the importance of aggressive surgical intervention for this disorder."

"Because Loeys-Dietz shares so many symptoms with other conditions like Marfan or vascular Ehlers-Danlos, it's critical that diagnostic distinctions are made accurately."

The researchers gathered detailed information on patients' physical characteristics, their symptoms, course of disease and timing and effect of treatments. They also used gene analysis of the DNA sequences that encode for two proteins, the transforming growth factor-beta protein receptors type 1 (TGF-betaR1) and type 2 (TGF-betaR2). All cases of Loeys-Dietz studied so far have mutations in either TGF-betaR1 or TGF-betaR2.

The two TGF-beta receptors act together to bind TGF-beta, a family of signaling molecules that controls cell growth, movement, activity and death by controlling whether certain genes are turned on or off. TGF-beta receptors normally are found on the cell's surface, facing the outside of the cell, where TGF-beta can be found floating around.

The receptors contain specialized domains - dubbed kinase domains -- that, when bound by TGF-beta, add a chemical phosphate group to molecules that set in motion a domino-like effect within the cell to activate other chemical
'"/>




Page: 1 2 3

Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists Review Loeys Dietz Syndrome the Largest Ever Study date

(Date:12/19/2014)... B. E. Smith, the only full-service leadership ... retained to lead a national chief financial officer ... The top executive search firm in the healthcare industry, ... healthcare executives into organizations. , Johnson Memorial Hospital ... to the residents of Johnson County and the surrounding ...
(Date:12/19/2014)... If you have ever been unable ... probably wished you had an arsenal of treatments to ... and other breathing disorders. Currently, the only proven methods ... but other common treatments do exist. At the ... Antonio, TX, 34 asthma educators responded to a Harmonica ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Consilium ... at the AMSUS Society for Federal Health Professionals ... locum tenens industry to military and federal healthcare ... the National Veterans Small Business Engagement (NVSBE) conference ... continues to be a vital solution in addressing ...
(Date:12/19/2014)... Amy Norton HealthDay Reporter ... moms who were exposed to high levels of air pollution ... autism, a U.S. study suggests. Researchers found that of ... 2002, those exposed to the most air pollution during pregnancy ... developed autism. And exposure during the third trimester, specifically, showed ...
(Date:12/17/2014)... 2014 While countless companies tempt patients to ... the potential dangers of their purchase. Not only is the ... qualified doctor, but patients who buy hCG online are typically ... is actually no real hCG present. Illegal internet hCG is ... no safety standards and may contain unknown fillers that can ...
Breaking Medicine News(10 mins):Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 3Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 2Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 3Health News:Consilium Staffing Increasing Awareness of Locum Tenens through Conference Appearances 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 3Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 2Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 3
... More than eight out of 10 homeless people surveyed ... least one chronic health condition and more than half have ... they live in unsafe, unstable or unaffordable housing--had equally poor, ... The underlying cause for these health issues is poverty, said ...
... By Serena Gordon HealthDay Reporter , TUESDAY, ... as nuts, to your diet can lower your cholesterol more ... Foods with plant sterols also have known cholesterol-reducing properties, and ... cholesterol by more than 13 percent. A low-fat diet alone ...
... , New York, NY, August 24, 2011 Nearly three-quarters (72%) ... their jobs over the last two years said that they ... because of cost, according to a new Commonwealth Fund ... or medical debt, compared to about half (49%) who lost ...
... Aug. 23 (HealthDay News) -- Accidental exposure to highly ... the United States, a new study finds. Researchers ... in outpatient chemotherapy infusion centers and found that nearly ... exposed to the drugs. In the United States, ...
... , TUESDAY, Aug. 23 (HealthDay News) -- ... appears to worsen over time and may lead to an ... people with diastolic dysfunction, which often comes with advancing age, ... abnormal way and is accompanied by elevated filling pressures. ...
... August 23, 2011 In a joint research effort ... with help from scientists at The University of Pennsylvania, ... Health, investigators from the Florida campus of The Scripps ... allows cells to rid themselves of damaged mitochondria, which ...
Cached Medicine News:Health News:Study: 85 percent of homeless people have chronic health conditions 2Health News:Certain Foods Said to Help Lower Bad Cholesterol 2Health News:Certain Foods Said to Help Lower Bad Cholesterol 3Health News:Three quarters of those who have lost jobs and health insurance are skipping needed health care 2Health News:Three quarters of those who have lost jobs and health insurance are skipping needed health care 3Health News:Three quarters of those who have lost jobs and health insurance are skipping needed health care 4Health News:Nurses at Risk for Accidental Exposure to Chemo Drugs: Study 2Health News:Common Heart Dysfunction Can Help Bring on Heart Failure 2Health News:Scripps Research scientists define cellular pathway essential to removing damaged mitochondria 2
(Date:12/19/2014)... INDIANAPOLIS and LYON, France ... (NYSE: LLY ) and Adocia (Euronext Paris: ... focused on developing an ultra-rapid insulin, known as BioChaperone ... type 2 diabetes. BioChaperone Lispro relies on Adocia,s proprietary ... Lilly and Adocia will develop BioChaperone Lispro ...
(Date:12/17/2014)... 2014 Los beneficios y ganancias ... nivel de gasto en investigación y desarrollo   ... 30 de septiembre de 2014) ZEISS aumentó sus ingresos ... euros (año anterior: 4.190 millones de euros) a pesar ... (EBIT) crecieron un 14 por ciento, a 360 millones ...
(Date:12/17/2014)... 2014  Northstar Global Business Services, Inc. (OTCPink:MDIN) ... has made their final decision and has determined ... stock effective December 15, 2014, and has resumed ... and book entry transfer services. All deposit restrictions have ... again fully "DTC Eligible", and has resumed electronic ...
Breaking Medicine Technology:Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 3ZEISS confirma su posición en un entorno difícil 2Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3
... Target Patients for ALIMTA(R), (pemetrexed for injection) ... Cancer, BARCELONA, Spain, Sept. 25 ... lung cancer (NSCLC) that,are classified as having ... when treated in the second-line setting with,ALIMTA(R) ...
... Mich. Sept. 24 Velcura Therapeutics, Inc., a,biotechnology ... the,U.S. Food and Drug Administration (FDA) Sept. 20 ... VEL-0230, a drug developed to treat bone,disease. The ... was to obtain feedback from the FDA,s Division ...
Cached Medicine Technology:Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 2Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 3Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 4Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 5Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 6Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 7Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 8Velcura Therapeutics, Inc. Reports Positive Pre-IND Meeting With FDA and Plans Early Clinical Trials for New Drug to Treat Multiple Myeloma Bone Disease 2Velcura Therapeutics, Inc. Reports Positive Pre-IND Meeting With FDA and Plans Early Clinical Trials for New Drug to Treat Multiple Myeloma Bone Disease 3
The ultimate combination of comfort, convenience and affordability, recommended for daily wear, also approved for extended wear (1-7 days)....
Acuvue2 is designed to be worn as a two-week daily wear lens (which means you take the lenses out each night). It can also be worn as a one-week extended wear lens (which means you can sleep in them)...
... water content spherical soft lens manufactured using ... molding technology, and designed for use in ... a daily wear or extended wear basis. ... transmission, while an increased mid-peripheral thickness allows ...
Hertel exophthalmometer...
Medicine Products: