Navigation Links
Scientists Revealed the Key Molecule That Controls Pain

Chronic pain, unlike the acute pain associated with trauma, has no apparent physiological benefit, often being referred to as the disease of pain .

Scientists studying one of natures simplest organisms have helped to unravel the structure of a key molecule that controls pain in humans. The findings published in the top scientific journal Nature could rapidly advance research into the next generation of painkillers for relief of chronic conditions such as migraine and backache.

Complete and lasting relief of chronic pain is rare and often the clinical goal is pain management through one or more medications But now researchers at The University of Manchester have examined microscopic amoeboid organisms commonly called slime moulds in a bid to gain greater insight into these pain molecules, known as P2X receptors.

In humans, P2X receptors look identical to one another and so scientists have had difficulty understanding how they function, said Dr Chris Thompson, who carried out the research with Professor Alan North and Dr Sam Fountain in the Faculty of Life Sciences.

By looking at slime mould we were effectively able to turn the evolutionary clock back a billion years to see how a more primitive P2X molecule functions.

The team discovered that there was only a 10% similarity between human P2X and the slime mould equivalent. They were therefore able to deduce from evolutionary theory that it was these similar parts of the molecule that probably regulate pain in humans.

Its a big step forward in understanding how the molecule works and should make it possible to develop drugs that block the receptors actions, said Dr Thompson.

Inhibiting P2X as a potential pain-relief therapy would be the Holy Grail of rational drug design and could revolutionise the way we manage chronic pain conditions like back pain and migraine.


'"/>




Page: 1

Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... ... May 23, 2017 , ... i2i Population Health, a national ... category winner, has named Daniel P. Bullington as chief technology officer. , “i2i ... and product offerings,” says Justin Neece, president. “Daniel is an excellent fit for ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... patients on peri-implantitis in Las Vegas, NV, and the importance of ... gum disease consultation and leading care for peri-implantitis, with or without a referral. ...
(Date:5/23/2017)... ... May 23, 2017 , ... New patients with symptoms of gum disease ... receive laser gum disease treatments from the doctors at Art of Dentistry, without first ... awareness of the importance of receiving qualified treatment in order to avoid systemic health ...
(Date:5/22/2017)... ... 2017 , ... Patients who avoid necessary dental and endodontic treatments because of ... NY from Advanced Endodontics of Westchester. This highly-trained team of endodontists offer three different ... sedation methods may be recommended based on the severity of the anxiety experienced by ...
(Date:5/22/2017)... ... ... Galena, Alaska, has a population of less than 500 people. But, the ... to build a nuclear plant by the TOSHIBA Corporation. , In “The Galena Nuclear ... the journey to get power to his small town, off the electrical grid. , ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)... , May 17, 2017  Bayer announced today ... portfolio will be presented at the 53 rd ... (ASCO), taking place June 2-6 in Chicago ... at ASCO span prostate, colorectal, liver and thyroid cancers, ... from the Phase II CHRONOS-1 trial of copanlisib in ...
(Date:5/10/2017)... May 10, 2017 Hologic, Inc. (Nasdaq: ... for the fiscal second quarter ended April 1, 2017 ... $1.84 increased 666.7% compared to the prior year period ... in a significant gain, while non-GAAP diluted EPS of ... or 3.8% in constant currency terms.  Excluding the effects ...
(Date:5/9/2017)... , May 9, 2017 Zimmer Biomet ... in musculoskeletal healthcare, today announced it has earned a ... of 2017" list. The Company was ranked among 500 ... Large Employers and Healthcare Equipment and Services. ... based on an anonymous, independent survey of over 30,000 ...
Breaking Medicine Technology: