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Scientists Pursue New Treatment For Asthma Sufferers

g caused by eosinophils,” says Fulkerson. “We only picked up the genes that were in common in both models, so we can say the changes were eosinophil dependent versus model dependent.

“So now we have this list of genes that are eosinophil dependent in an experimental animal model and we’re identifying new pathways that have never been attributed to eosinophils before,” Fulkerson adds. “Now we and other researchers will pursue this to learn exactly what eosinophils are doing to those pathways and to see how we can block their contributions to asthma.

Some of these genetic pathways were known to be important in asthma, says Fulkerson, but no one had previously attributed them to eosinophils.

“That’s the exciting part,” she says. “If we can prevent eosinophils from being activated, then perhaps we can develop new targets for treatment. The goal is to find new approaches to asthma, because although we can treat asthma symptoms fairly well, we’re not so good at dealing with the long-term consequences.

“And this doesn’t only involve asthma. There are a lot of other diseases, especially digestive diseases, in which we see high levels of eosinophils that don’t belong there,” Fulkerson says.

Also contributing to the research were Christine Fischetti, Melissa McBride, Lynn Hassman and Simon Hogan, all of Cincinati Children’s.

Source-Eurekalert
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