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Scientists Partner to Develop and Distribute New Tuberculosis Vaccine

rigerated storage and has shown variable degrees of protection against tuberculosis in different parts of the world. Because of such limitations, public health experts and physicians have long seen a need for alternatives to the traditional BCG vaccine and current treatment strategies.

The spray drying process Edwards developed for the BCG vaccine is similar to the way manufacturers prepare powdered milk. In fact, Edwards's first exposure to the spray drying process occurred when he was working with a spray dryer to produce highly respirable drug aerosols in a food science lab.

While spray drying of small and large molecules is common in the food, cosmetic, and pharmaceutical industries, the method has not been commonly used for drying cellular material. Most important, the new technique enables the BCG vaccine, and potentially other bacterial and viral-based vaccines, to be dried without the traditional problems associated with standard freezing.

"Unlike traditional freezing techniques, spray drying is lower-cost, easily scaleable for manufacturing, and ideal for use in needle-free formulations, such as inhalation," Edwards says. "Its greater stability at room temperature and viability ultimately could provide a more practical approach for creating and delivering a vaccine throughout the world.”

Source-Eurekalert
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