Navigation Links
Scientists Observed Live Cell Migration

Johns Hopkins researchers have found a way to directly observe cell migration -- in real time and in living tissue. Cell, the scientists say their advance could lead to strategies for controlling both normal growth and the spread of cancer, processes that depend on the programmed, organized movement of cells across space.

"The stars of our live show are a cluster of fruit fly cells that literally crawl across the length of an egg chamber while it is maturing," says Denise Montell, Ph.D., professor of Biological Chemistry and director of the Center for Cell Dynamics. "What these border cells are doing resembles what cancer cells do when they migrate from the main growth to other tissues."

The historic problem, Montell says, is that its been impossible to watch this process inside the ovarian tissue -no microscope can do that - and worse, the cells stop moving if theyre outside the ovaries. In a years-long effort, Montell and her team figured out just what to feed these cells to keep them alive and doing their thing without their ovarian homes.

"We were stuck having to watch this through a series of still pictures and losing a lot of the story, "Montell says. "Now with real-time movies, were deciphering the nuances behind organized cell movement that should offer opportunities for hopefully regulating the process."

Among the nuances identified is that just like migrating geese or a pack of bicyclists, individual border cells in the cluster each take turns as the "leader" during their journey across the egg chamber. Another discovery is that a protein called Kuzbanian is necessary to help border cells detach from the egg wall and begin their journey.

"We used to think that Kuzbanian allowed border cells to squeeze themselves between other cells as they moved," Montell says, "but only now do we understand the real reason cells couldnt move. We can see them valiantly trying to detach from the wall but unable to pull away."

Montell and her team tediously worked out a recipe for a liquid culture medium that gave the fly eggs the ability to grow outside ovaries. The list of ingredients included acidity, and a little bit of insulin.

Because many border cell proteins in flies have counterparts in humans, Montells studies should translate to a better understanding of clinically useful cell migrations, such as when immune cells move en masse to an open wound or cancer cells detach from a tumor to metastasize.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
Breaking Medicine Technology: