Navigation Links
Scientists Observed Live Cell Migration

Johns Hopkins researchers have found a way to directly observe cell migration -- in real time and in living tissue. Cell, the scientists say their advance could lead to strategies for controlling both normal growth and the spread of cancer, processes that depend on the programmed, organized movement of cells across space.

"The stars of our live show are a cluster of fruit fly cells that literally crawl across the length of an egg chamber while it is maturing," says Denise Montell, Ph.D., professor of Biological Chemistry and director of the Center for Cell Dynamics. "What these border cells are doing resembles what cancer cells do when they migrate from the main growth to other tissues."

The historic problem, Montell says, is that its been impossible to watch this process inside the ovarian tissue -no microscope can do that - and worse, the cells stop moving if theyre outside the ovaries. In a years-long effort, Montell and her team figured out just what to feed these cells to keep them alive and doing their thing without their ovarian homes.

"We were stuck having to watch this through a series of still pictures and losing a lot of the story, "Montell says. "Now with real-time movies, were deciphering the nuances behind organized cell movement that should offer opportunities for hopefully regulating the process."

Among the nuances identified is that just like migrating geese or a pack of bicyclists, individual border cells in the cluster each take turns as the "leader" during their journey across the egg chamber. Another discovery is that a protein called Kuzbanian is necessary to help border cells detach from the egg wall and begin their journey.

"We used to think that Kuzbanian allowed border cells to squeeze themselves between other cells as they moved," Montell says, "but only now do we understand the real reason cells couldnt move. We can see them valiantly trying to detach from the wall but unable to pull away."

Montell and her team tediously worked out a recipe for a liquid culture medium that gave the fly eggs the ability to grow outside ovaries. The list of ingredients included acidity, and a little bit of insulin.

Because many border cell proteins in flies have counterparts in humans, Montells studies should translate to a better understanding of clinically useful cell migrations, such as when immune cells move en masse to an open wound or cancer cells detach from a tumor to metastasize.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... ... March 23, 2017 , ... Texas Physical Therapy Specialists (TexPTS) is ... in Building 2. The clinic is the group’s second in New Braunfels and 22nd ... company’s second New Braunfels location brings things full circle for the group, “It’s crazy ...
(Date:3/23/2017)... ... ... 82% of adults are unaware of the dangers that infectious bacteria play in mouth disease, ... times a day that dentists recommend. The ramifications of improper oral upkeep go far beyond ... missing 164 million hours of work each year due to dental issues. That is why ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... Oriented Disease Management Accreditation from the NCQA. The accreditation covers StayWell’s asthma, coronary ... , Accredited status is granted to organizations that have excellent programs for the ...
(Date:3/23/2017)... Fort Collins, CO (PRWEB) , ... March 23, ... ... services firm serving the families and businesses of the greater Fort Collins area, ... charity campaign in their ongoing community involvement program. Donations to this worthy cause ...
(Date:3/23/2017)... ... ... conference will prominently feature 150+ Hospital and Health System Executive Speakers including: , ... 43rd President of the United States of America: George W. Bush , ... the Ring: Sugar Ray Leonard , JD, Chairperson, McGuireWoods LLP: Amber McGraw Walsh ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... March 23, 2017 As a result ... with the prevalence of allergic diseases, cutting edge ... currently revolutionising the ways in which pharmaceutical and ... 2017 promises to be both a high quality ... allergy interest groups, immunologists, research scholars and doctors. ...
(Date:3/23/2017)... Summary Global ... guide Primary Hyperoxaluria - Pipeline Review, H1 2017, ... Urinary System And Sex Hormones) pipeline landscape. ... recurrent kidney and bladder stones. It results from ... include blood in the urine, pain when urinating, ...
(Date:3/23/2017)... and VANCOUVER, British Columbia , ... SPHS ) (the "Company" or "Sophiris"), a clinical ... of urological diseases, today announced that data from its ... drug as a focal treatment for localized prostate cancer, ... 2017 at the 32 nd Annual European Association ...
Breaking Medicine Technology: