Navigation Links
Scientists Observed Live Cell Migration

Johns Hopkins researchers have found a way to directly observe cell migration -- in real time and in living tissue. Cell, the scientists say their advance could lead to strategies for controlling both normal growth and the spread of cancer, processes that depend on the programmed, organized movement of cells across space.

"The stars of our live show are a cluster of fruit fly cells that literally crawl across the length of an egg chamber while it is maturing," says Denise Montell, Ph.D., professor of Biological Chemistry and director of the Center for Cell Dynamics. "What these border cells are doing resembles what cancer cells do when they migrate from the main growth to other tissues."

The historic problem, Montell says, is that its been impossible to watch this process inside the ovarian tissue -no microscope can do that - and worse, the cells stop moving if theyre outside the ovaries. In a years-long effort, Montell and her team figured out just what to feed these cells to keep them alive and doing their thing without their ovarian homes.

"We were stuck having to watch this through a series of still pictures and losing a lot of the story, "Montell says. "Now with real-time movies, were deciphering the nuances behind organized cell movement that should offer opportunities for hopefully regulating the process."

Among the nuances identified is that just like migrating geese or a pack of bicyclists, individual border cells in the cluster each take turns as the "leader" during their journey across the egg chamber. Another discovery is that a protein called Kuzbanian is necessary to help border cells detach from the egg wall and begin their journey.

"We used to think that Kuzbanian allowed border cells to squeeze themselves between other cells as they moved," Montell says, "but only now do we understand the real reason cells couldnt move. We can see them valiantly trying to detach from the wall but unable to pull away."

Montell and her team tediously worked out a recipe for a liquid culture medium that gave the fly eggs the ability to grow outside ovaries. The list of ingredients included acidity, and a little bit of insulin.

Because many border cell proteins in flies have counterparts in humans, Montells studies should translate to a better understanding of clinically useful cell migrations, such as when immune cells move en masse to an open wound or cancer cells detach from a tumor to metastasize.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/18/2017)... ... ... From a health perspective, 2017 will clearly be the Year of the Gut. ... health and general physical well-being. The New York Times suggested a “ Gut Makeover ... Charlottesville restaurant, good gut health is clearly on the menu. Threepenny Cafe ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... and most-read publication among specialty pharmacists and pharmacy professionals, has teamed up ... Alliance Partnership (SAP) program, announced Brian Haug, president of Pharmacy Healthcare Communications, ...
(Date:1/18/2017)... Spring, MD (PRWEB) , ... January 18, 2017 , ... ... financial consultations to families and business owners in central Maryland and the DC region, ... , Heart disease kills 787,000 people nationally every year, making it the #1 killer ...
(Date:1/18/2017)... ... January 18, 2017 , ... Catalent ... for drugs, biologics and consumer health products, today announced that Mr. Michael Merges, ... upcoming WCBP Conference, to be held at the Mayflower Hotel, Washington DC, on ...
(Date:1/18/2017)... ... 18, 2017 , ... During pregnancy, women are at an ... those dental problems can increase the risk of pregnancy complications. Unfortunately, according to ... to get the dental care they need. Agoura Hills dentist, Philip Shindler ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... FALLS, N.J. , Jan. 18, 2017   ... ), a biotechnology company specializing in the development and ... of damaged tissues and organs, recently reported the Company,s ... milestones for 2017. As the Company described ... has been a year of substantial accomplishments. The Company,s ...
(Date:1/18/2017)... , Jan 18, 2017 Research and Markets ... Vomiting Drugs Market 2017-2021" report to their offering. ... The global CINV drugs ... 2017-2021. Global Thoracic Surgery Market 2017-2021, has been ... experts. The report covers the market landscape and its growth prospects ...
(Date:1/18/2017)... , January 18, 2017 The report " Automated ... Automated Breast Volume Scanner), By End User (Hospitals, Diagnostic Imaging Centers), Industry Analysis ... , Argentina , Germany , UK, ... , Russia , China , ... Thailand , Saudi Arabia , UAE, ...
Breaking Medicine Technology: