Navigation Links
Scientists Observed Live Cell Migration

Johns Hopkins researchers have found a way to directly observe cell migration -- in real time and in living tissue. Cell, the scientists say their advance could lead to strategies for controlling both normal growth and the spread of cancer, processes that depend on the programmed, organized movement of cells across space.

"The stars of our live show are a cluster of fruit fly cells that literally crawl across the length of an egg chamber while it is maturing," says Denise Montell, Ph.D., professor of Biological Chemistry and director of the Center for Cell Dynamics. "What these border cells are doing resembles what cancer cells do when they migrate from the main growth to other tissues."

The historic problem, Montell says, is that its been impossible to watch this process inside the ovarian tissue -no microscope can do that - and worse, the cells stop moving if theyre outside the ovaries. In a years-long effort, Montell and her team figured out just what to feed these cells to keep them alive and doing their thing without their ovarian homes.

"We were stuck having to watch this through a series of still pictures and losing a lot of the story, "Montell says. "Now with real-time movies, were deciphering the nuances behind organized cell movement that should offer opportunities for hopefully regulating the process."

Among the nuances identified is that just like migrating geese or a pack of bicyclists, individual border cells in the cluster each take turns as the "leader" during their journey across the egg chamber. Another discovery is that a protein called Kuzbanian is necessary to help border cells detach from the egg wall and begin their journey.

"We used to think that Kuzbanian allowed border cells to squeeze themselves between other cells as they moved," Montell says, "but only now do we understand the real reason cells couldnt move. We can see them valiantly trying to detach from the wall but unable to pull away."

Montell and her team tediously worked out a recipe for a liquid culture medium that gave the fly eggs the ability to grow outside ovaries. The list of ingredients included acidity, and a little bit of insulin.

Because many border cell proteins in flies have counterparts in humans, Montells studies should translate to a better understanding of clinically useful cell migrations, such as when immune cells move en masse to an open wound or cancer cells detach from a tumor to metastasize.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... Ongoing news ... Aging Life Care Association™ (ALCA) to conduct a survey that takes a closer look ... released today illustrates the prevalence and causes of TBI among the aging population, and ...
(Date:2/10/2016)... ... February 10, 2016 , ... AxoGen, Inc. (NASDAQ: AXGN), a ... for the fourth quarter and full year ended December 31, 2015 on Monday, February ... and webcast for the investment community following the release at 4:30 PM ET. Investors ...
(Date:2/10/2016)... ... ... For additional information contact Phyllis Strupp 480-488-5858 , Brain improves with age, ... Guide to Brain Training" by award-winning author Phyllis Strupp explains how brain ... 16, 2016. A free review copy is available to the media at NetGalley ...
(Date:2/10/2016)... ... 2016 , ... IDEX Health & Science, LLC announces the ... columns combine the strength of traditional stainless steel with the chemical inertness of ... operating at ultra-high pressures of 20,000 psi. The higher operating pressures allow faster ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... The recreational ... cannabis enthusiasts in the state still face a lot of restrictions as to where ... is intended for private, personal use” and that cannabis “may not be consumed openly ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... , Feb. 10, 2016  The Baylor ... received an in-kind gift from ... VeinViewer® Vision vein finder for the nursing ... students as they learn how to start ... with traditional technique. ...
(Date:2/10/2016)... , Feb. 10, 2016  LexisNexis® Risk ... technology, today announced the launch of LexisNexis ... solution that helps improve and optimize the quality ... of performance using severity-adjusted scores. By measuring provider ... critical solution to deliver better outcomes, improve the ...
(Date:2/10/2016)... 10, 2016 Convergence scenarios are ... various technologies that results in diverse solutions ... opportunities create a cyclical system where technology ... the development of new technologies. ... technology convergences, which are constantly fostering new ...
Breaking Medicine Technology: