Navigation Links
Scientists Map Genome Sequence Dengue Mosquito

Scientists have completed the first draft of the genome sequence of Aedes aegypti mosquito, thereby moving one step further towards the development of new strategies to prevent and control yellow fever and dengue fever.

The genome sequencing was done by researchers from 24 universities and other institutions, led by Vishvanath Nene at The Institute for Genomic Research (TIGR) and David Severson at the University of Notre Dame.

Zhijian Tu, a co-author and member of the Vector-Borne Infectious Disease Research Group at Virginia Tech, helped annotate transposable elements (TEs), genetic material that move around the mosquitos genome and have a significant impact on its structure and size.

Another Virginia Tech researcher Jinsong Zhu, Assistant Professor of Biochemistry, has so far helped validate 80 per cent of the15,419 predicted protein coding genes in Ae. aegypti.

"An important part of this project is gene annotation which predicts numbers and locations of mosquito genes in the genome. In parallel to sequencing DNA in chromosomes, scientists have also sequenced large amounts of messenger RNAs collected from different mosquito tissues at distinct developmental stages. Matching a messenger RNA to a predicted gene will validate authenticity of this gene," he explains.

Zhijian Tus team has uncovered and described more than 1,000 TEs that occupy about 50 per cent of the entire Ae. Aegypti genome.

"Although the majority of protein coding TE copies in Ae. aegypti appear to be degenerate, a significant number of elements have potentially active TE copies, indicating that they may be developed as tools for genetic studies of mosquitoes," said the researcher.

"If you look at the genome as an ecological system, TEs are different lineages that co-evolve with the rest of the genome. They evolve different relationships with the genome. Some are genetic parasites; they appear to do nothing except replicate within the genome. Others are used by the host -- the individual organism's genetic machinery --to perform biological functions," Tu added.

The researchers believe that TEs may be developed as genetic tools to study the interaction between mosquitoes and pathogens, and thus may lead to controls of transmission of disease.

They said that the control might take the form of a genetic control, such as using TEs to carry a gene into the genome that would make the mosquito resistant to the virus, and stop its role as a vector for disease.

"By introducing TEs in a more or less random way to see what happens to the laboratory mosquitoes, the TEs become a tool to study the genetic mechanism of mosquito-virus interaction, to help us understand mosquito biology and reveal new ways to interfere with disease transmission," Tu said.

The Ae. aegypti genome sequence has been described in the article Genome Sequence of Aedes aegypti, A Major Arbovirus Vector, published in Science Express. It is expected to stimulate efforts to elucidate interactions at the molecular level between mosquitoes and the pathogens they transmit to humans.


Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:

(Date:12/1/2015)... ... , ... With FCPX Overlay: Grit , users can apply a grit ... are truly endless, all with a click of a mouse. Each user has full ... depth of field and more, all within Final Cut Pro X. , With FCPX ...
(Date:12/1/2015)... ... December 01, 2015 , ... SonaCare ... 2015 HSJ Acute Sector Innovation Award on November 18th. This prestigious award recognizes ... and propose exciting enhancements to the medical landscape. , The UCLH team won ...
(Date:11/30/2015)... ... 30, 2015 , ... Olympic Gold Medalists and Celebrity Moms ... across various categories through traditional and social media marketing campaigns and other branding ... Gold Medal Moms who can connect with today’s most important consumer: mothers. In ...
(Date:11/30/2015)... NY (PRWEB) , ... December 01, 2015 , ... ... honors Christina Colon as a 2015-2016 inductee into its VIP Woman ... in pharmacy. NAPW is the nation’s leading networking organization exclusively for professional women, ...
(Date:11/30/2015)... Los Angeles, California (PRWEB) , ... November 30, ... ... in all the programs of the19th Bi-National Convention of the Federation of Philippine ... Resort and Casino in Las Vegas, Nevada. , 1Heart Caregiver Services, as ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... BASEL, Switzerland , Dec. 1, 2015  Roche ... wholly-owned UK subsidiary Proximagen Ltd., today announced a worldwide ... small molecule inhibitor of Vascular Adhesion Protein 1 (VAP-1), ... treatment of inflammatory disease. The VAP-1 inhibitor is currently ... --> Under the terms of the ...
(Date:11/30/2015)... LOUIS , Dec. 1, 2015 Express Scripts ... Imprimis Pharmaceuticals (NASDAQ: IMMY ) to drive access to ... for the treatment of toxoplasmosis that has been recently priced ... others with weakened immune systems. --> ... of pyrimethamine and leucovorin (a form of folic acid) for $1 ...
(Date:11/30/2015)... Die MEDTEC Japan 2016, ... Entwicklung und Herstellung medizinischer Geräte, findet ... in Tokyo ... Foto: ... --> ...
Breaking Medicine Technology: