Navigation Links
Scientists Make World Breakthrough

A team of scientists from the University of Adelaide, Monash University and the United States has made a world breakthrough in understanding how bacterial toxins cause// severe gastrointestinal diseases.

The scientists, led by Dr Adrienne Paton from the University of Adelaide’s School of Molecular and Biomedical Science, have discovered that a highly potent bacterial toxin kills cells by inactivating an essential component in the endoplasmic reticulum (ER). The latter is part of the cell that is essential for packaging newly-synthesized proteins.

The toxin, called subtilase cytotoxin, is produced by certain strains of E. coli bacteria responsible for severe gastrointestinal disease in humans. Dr Paton discovered the toxin in 2003 in a bacterium responsible for an outbreak of haemolytic uraemic syndrome (severe food poisoning) in South Australia. Subtilase cytotoxin is so potent that it is a potential bio-terrorism agent.

Dr Paton and her colleagues published their findings today in Nature, the prestigious international weekly scientific journal.

“The ER is a command centre of the cells of higher organisms, second only to the nucleus in its influence on other cellular functions,” Dr Paton says. “The molecule targeted by the toxin is a chaperone protein called BiP, which is a master regulator of ER function. Disrupting this crucially important chaperone has inevitably fatal consequences for a wide range of cell types.”

As well as learning how the toxin works, the scientists have also determined its three-dimensional structure, which will help in the development of treatments for toxin-related diseases.

Dr Paton says the breakthrough may also provide insights into the development of age-related and degenerative diseases such as Parkinson’s disease and Alzheimer’s disease, which involve defects in ER function.

Scientific colleagues working on the discovery with Dr Paton included fellow r
'"/>




Page: 1 2

Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists Make World Breakthrough

(Date:5/24/2015)... 24, 2015 EnviroLeather™ by LDI, ... Plus” – a classic, rugged leather grain with ... difficult stains, including ink, to be easily removed. ... suitable for corporate, healthcare, hospitality and education environments. ... EnviroLeather’s goal of developing products that are more ...
(Date:5/24/2015)... 2015 Medicx Media Solutions ... executive Jay Krihak as its head of programmatic ... up its expertise and leadership position in the ... Health sectors. , Krihak is an experienced, award-winning ... Krihak led sales planning teams for mobile platform ...
(Date:5/23/2015)... 23, 2015 On May 13, Nithyananda ... a youngster's yogic power learned through meditation and initiation ... in Bangalore, India. , Yogamaatha, a nine-year-old girl from ... high profile professionals attending the 2015 Business Advocacy Summit ... -- blindfolded. , In a demonstration that lasted ...
(Date:5/23/2015)... Parker, CO (PRWEB) May 23, 2015 On ... participated in MuckFest. The event was a 5k mud obstacle ... affects more than 2 million people worldwide, and the reason ... our community,” said Chad Davis, owner of Farrell’s eXtreme Bodyshaping. ... National Multiple Sclerosis Society.” , The event was not only ...
(Date:5/23/2015)... Add High-Quality prismatic refractions into footage using ... It's as simple as dragging and dropping footage into the ... full effect. , Including over 80 stunning flares, ProFlare ... making this the ultimate bundle for adding prismatic refractions to ... package are movie files designed for Final Cut Pro X, ...
Breaking Medicine News(10 mins):Health News:EnviroLeather By LDI Launches "InkGard Plus" - Stain Resistant Faux Leather 2Health News:Medicx Media Solutions Expands Executive Team 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3Health News:Farrell’s eXtreme Bodyshaping Team Runs through the Muck for MS 2Health News:Developers at Pixel Film Studios Release ProFlare 5K Prism for Final Cut Pro X. 2
... high for some women, study suggests , , , TUESDAY, ... many women, mammography is far from perfect. But, undergoing ... more cancers in high-risk women, particularly those with dense ... study authors noted, ultrasound also significantly increases the rate ...
... Mich., May 13 CJPS Enterprises, LLC, (http://www.CJPS-Enterprises.com ... a,half-day mini-seminar and interactive discussions about building up, ... their,competitiveness, and therefore their worth. This seminar will ... 2008 and is applicable to both large,and small ...
... Attorneys for a married,couple who lived in the fundamentalist ... District Court judge today for an emergency order,to prevent ... is still,nursing, when he turns a year old on ... presiding judge at 3:30 p.m.,seeking an emergency injunction to ...
... SEATTLE, May 13 The Epilepsy Foundation,Northwest announces ... and Portland. The events will occur on Saturday, June ... Riverfront Park. The following,day, Sunday, June 22, Portland will ... from 9:30 am-12:00 pm., "Everyone is invited to ...
... Support Local 332 Nurses Negotiating With Genesys Regional,Medical Center, ... Hoffa and Michigan Lt. Gov. John Cherry will lead ... for more than 1,000,Local 332 nurses in contract negotiations ... to maintain low nurse-to-patient ratios and to,continue quality, affordable ...
... Pa., May 13 Vibra Healthcare, LLC,announced today ... Care Hospital,(LTACH) in southeastern Michigan. The 83 bed ... LTACH in Michigan. It will be known as,Vibra ... and rehabilitative care to medically,complex patients. These patients ...
Cached Medicine News:Health News:Coupled With Mammography, Ultrasound Finds More Breast Cancers 2Health News:Coupled With Mammography, Ultrasound Finds More Breast Cancers 3Health News:Intellectual Property Buildup Seminar to be Held in Detroit 2Health News:FLDS Couple Seeks Emergency Order to Stop Infant Seizure, Say Perry & Haas 2Health News:FLDS Couple Seeks Emergency Order to Stop Infant Seizure, Say Perry & Haas 3Health News:Vibra Healthcare Acquires the Kindred Long Term Acute Care Hospital in Southeastern Michigan 2
(Date:5/21/2015)... 21, 2015  (MUSE Booth # 1510)What:Automating continuous ... (EHR) is invaluable in any hospital setting, but ... a requirement and mainstream in healthcare, the integration ... EHR is gaining traction in MEDITECH facilities.During MUSE ... Site Project Manager & Clinical Analyst at McLaren ...
(Date:5/21/2015)... Mai 2015 Dipexium Pharmaceuticals, ... Unternehmen für Arzneimittel im fortgeschrittenen Entwicklungsstadium, ... Vermarktung von Locilex® (Pexiganan-Creme 0,8 %) und ... wissenschaftliche Posterpräsentation an, welche das innovative ... OneStep-1 und OneStep-2, in der Locilex® ...
(Date:5/21/2015)... CHICAGO , May 21, 2015  Heidrick & ... executive search , leadership consulting and ... life sciences expertise among global practices announcing the addition ... Chicago office. Dietlin ... has worked globally and across R&D, Medical and Commercial ...
Breaking Medicine Technology:Hospital Streamlines ICU Efficiency with Timely Data Integration 2Hospital Streamlines ICU Efficiency with Timely Data Integration 3Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 2Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 3Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 4Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 5Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 6Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 7Heidrick Increases Healthcare and Life Sciences Expertise 2
... at AACR, SAN DIEGO, April 17 /PRNewswire-FirstCall/ ... in vitro study showing,that the active metabolite ... response by inducing cytokine secretion,cytolysis of tumor ... a poster presentation at the Annual,Meeting of ...
... ANGELES, April 17, 2007 /PRNewswire/ -- Researchers from ... presented,strong evidence today that an antibiotic typically prescribed ... types of cancers. , Q. Ping Dou, Ph.D., ... lab announced the findings of their study showing,that ...
Cached Medicine Technology:Anadys Reports Preclinical Data Showing ANA773 Promotes Anti-Tumor,Activity of Natural Killer Cells 2Anadys Reports Preclinical Data Showing ANA773 Promotes Anti-Tumor,Activity of Natural Killer Cells 3Anadys Reports Preclinical Data Showing ANA773 Promotes Anti-Tumor,Activity of Natural Killer Cells 4Alzheimer's Drug Shows Promise in Fighting Cancer 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: