Navigation Links
Scientists Make World Breakthrough

A team of scientists from the University of Adelaide, Monash University and the United States has made a world breakthrough in understanding how bacterial toxins cause// severe gastrointestinal diseases.

The scientists, led by Dr Adrienne Paton from the University of Adelaide’s School of Molecular and Biomedical Science, have discovered that a highly potent bacterial toxin kills cells by inactivating an essential component in the endoplasmic reticulum (ER). The latter is part of the cell that is essential for packaging newly-synthesized proteins.

The toxin, called subtilase cytotoxin, is produced by certain strains of E. coli bacteria responsible for severe gastrointestinal disease in humans. Dr Paton discovered the toxin in 2003 in a bacterium responsible for an outbreak of haemolytic uraemic syndrome (severe food poisoning) in South Australia. Subtilase cytotoxin is so potent that it is a potential bio-terrorism agent.

Dr Paton and her colleagues published their findings today in Nature, the prestigious international weekly scientific journal.

“The ER is a command centre of the cells of higher organisms, second only to the nucleus in its influence on other cellular functions,” Dr Paton says. “The molecule targeted by the toxin is a chaperone protein called BiP, which is a master regulator of ER function. Disrupting this crucially important chaperone has inevitably fatal consequences for a wide range of cell types.”

As well as learning how the toxin works, the scientists have also determined its three-dimensional structure, which will help in the development of treatments for toxin-related diseases.

Dr Paton says the breakthrough may also provide insights into the development of age-related and degenerative diseases such as Parkinson’s disease and Alzheimer’s disease, which involve defects in ER function.

Scientific colleagues working on the discovery with Dr Paton included fellow r esearchers from the University of Adelaide, Professor James Paton and Ursula Talbot; Dr Celeste Thorpe from Tufts New England Medical Center in Boston; and Professor Jamie Rossjohn, Dr Travis Beddoe, Dr Matthew Wilce and Dr James Whisstock from Monash University.

Dr Beddoe said: “This is a great example of Australian scientists collaborating to address important and timely biological problems. We had to use a combination of techniques, including that of synchrotron radiation, to unravel the secrets of the toxin.”

Source-Newswis
SRM
'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... , ... TherapySites, the leading website and online ... Counseling Association. This new relationship allows TherapySites to continue to extend their ... benefits and promotional offers. , "TCA is extremely excited about this new partnership, ...
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified ... be personalized through a fitness app. The fitness app plans to fix the two major ... only offer a one size fits all type program , They don’t eliminate ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
Breaking Medicine Technology: