Navigation Links
Scientists Identity Genetic Risk Factor for Head and Neck Cancer

A recent study finds that a simple blood test may be able to identify those most at risk for developing// head and neck cancer as a result of smoking.

This was the finding by Prof. Zvi Livneh, Head of the Weizmann Institute's Biological Chemistry Department, Dr. Tamar Paz-Elizur of the same department, and their research team that worked in collaboration with of Tel Aviv-Sourasky Medical Center, Prof. Laurence Freedman of Sheba Medical Center and Prof. Edna Schechtman of Ben-Gurion University of the Negev.

Livneh's research deals with repair mechanisms for DNA, the material of genes. Cells maintain sophisticated repair systems to prevent the accumulation of mutations that might lead to cancer. In these systems, molecular detectors scan the DNA for injury. A sort of local operation is then performed to cut out and dispose of the damaged segment and replace it with a new one.

In their study, which appeared in Cancer Research, the scientists asked whether a reduced individual ability (non-inherited) to repair DNA damage increases chances of getting head and neck cancer. Smoking damages DNA and is known to be a major cause of this disease, which can affect the throat, mouth and larynx. The researchers focused on a DNA repair enzyme called OGG1, for which they had previously developed a blood test to measure activity levels.

By comparing OGG activity in healthy people with those in head and neck cancer patients, the research team found that the test was able to single out those with a heightened risk of this type of cancer: Weak levels were correlated with greater risk. According to Prof. Livneh, a smoker with low OGG activity is 70 times more likely to develop head and neck cancer than a non-smoker with normal OGG levels.

These findings join a previous study by the group in which they found that low OGG activity is an indicator of elevated risk for lung cancer, a disease also caused by smoking. Together, th ese studies show that a combination of low OGG activity and smoking can skyrocket a person's chances of becoming ill with a smoking-related cancer. Also participating in the study were Dalia Elinger of the Biological Chemistry Department, Dr. Akiva Vexler of Tel Aviv-Sourasky Medical Center, Profs. Adi Shani and Alain Berrebi of Kaplan Medical Center, and Dr. Meir Krupsky of Sheba Medical Center.

The OGG blood test might be used, in the future, to identify those most at risk for lung and head and neck cancers, hopefully giving added incentive to those with the risk factor to quit smoking. In addition, drugs might be developed to reduce this risk, similar to those prescribed today to reduce the risk of heart disease.



Source-Eurekalert
SRI
'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/21/2017)... ... January 21, 2017 , ... Salveo for life, a ... bringing its product to the United States as part of its presence to expand ... years, Alcovit aims to reduce the productions of nasty toxins as a result of ...
(Date:1/21/2017)... (PRWEB) , ... January 21, 2017 , ... ... Redwood Family Dermatology has recently joined their multi-specialty medical group. The ... range of cosmetic services. , “We’re excited to add this excellent dermatology practice ...
(Date:1/20/2017)... ... January 20, 2017 , ... A new partnership between Goodwill® ... no longer use or need, from clothes to couches to dressers and bicycles. Roadie ... take them to the nearest Goodwill donation center through February 28th. , “January ...
(Date:1/20/2017)... ... ... Lice Troopers, the lice removal company based in South Florida, has seen a ... , “It happens every year around this time,” says owner, Arie Harel. “Many ... the head-to-head gateway that lice need to spread.” , As children return to classrooms ...
(Date:1/20/2017)... ... January 20, 2017 , ... Vitamin ... alternative VW+ 002. The drinks have been produced in collaboration with Zlatan Ibrahimovic ... during your workout. , After a successful launch in Sweden last year, the ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 19, 2017 Incretin Mimetics/GLP-1 Agonists, SNDRIs, Lipase ... The global anti-obesity drugs market is expected to ... the forecast period and CAGR of 38.7% in the second half ... a CAGR of 32.8% from 2016 to 2027. The market is ... $24,063 million in 2027. ...
(Date:1/19/2017)... -- Accuray Incorporated (Nasdaq: ARAY ) announced ... set the bar for excellence in customer satisfaction. The ... rating among radiation treatment delivery systems in the U.S., ... Briefing™. The most recent ratings trend also shows Accuray ... for 11 of the past 12 quarters. ...
(Date:1/19/2017)... LONDON , January 19, 2017 ... Grothey ; European Oncology & Haematology, 2016;12(Suppl 2):3-8; ... ... http://photos.prnewswire.com/prnh/20151014/276718LOGO) Published recently in ... the peer-reviewed journal from touchONCOLOGY, an article by ...
Breaking Medicine Technology: