Navigation Links
Scientists Identify the Most Significant Single Predictor of Aggressive Prostate Cancer

An elevated rate of increase in prostate specific antigen (PSA) levels is the most significant predictor of aggressive form of prostate cancer, according to a new study published in the journal Cancer.

The study suggests if the rate of PSA increase prior to treatment (PSA Velocity) is more than 2 ng/ml/year, it is an indication of a high risk of death from prostate cancer.

According to the researchers, the new findings attain significance with recent studies suggesting that factors like microscopic features of the tumour (Gleason score), and size, spread and location of the disease are not very effective to determine prognosis.

Dr. Anthony DAmico of Bostons Brigham and Womens Hospital and colleagues characterised PSA velocity significant in prostate cancer-specific mortality (PCSM) rates following treatment with radical prostatectomy (RP) or radiation therapy (RT).

The researchers reviewed data from 948 men with localized prostate cancer who had one or more high-risk factors, and found that PSA velocity appeared to be the most important single prognostic factor. They observed that men who had multiple risk factors died from their disease significantly earlier than those who had only one factor.

Among men who underwent treatment with RP or RT, 44 per cent and 28 per cent, respectively, had pre-treatment PSA velocities of 2 ng/ml/year as their only identified high-risk factor.

It was observed that of those men who died with only one identified high-risk factor, 88 per cent of RP-treated patients and 80 per cent of RT-treated patients had pre-treatment PSA velocities of 2 ng/ml/year.

The study authors have also pointed out at the results of various other studies that have shown that the time to death shortens as PSA velocity increases, which suggests that further research should examine using stratified PSA velocities to assess risk in men with localised disease.

"These findings hi ghlight the ability of a pre-treatment PSA velocity 2 ng/ml/year alone to identify men with aggressive prostate cancer and in whom effective systemic treatment in addition to mono-therapy with RP or RT is needed to decrease PCSM rates," conclude the authors.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... ... ... The Radiology Business Management Association (RBMA) has named the nine winners ... year, are among the most prestigious in radiology marketing because a panel of radiology ... recognize achievements in both large budget (over $5,000) and small budget (under $5,000) campaigns. ...
(Date:3/24/2017)... ... ... The iaedp Foundation, the premier provider of educational programs and training standards ... full spectrum of disordered eating, announced today that the 2017 Symposium set a new ... and several countries converged on the Green Valley Resort in Las Vegas. , ...
(Date:3/24/2017)... Calif. (PRWEB) , ... March 24, 2017 , ... ... raised over $100,000 for its innovative EcoQube Frame vertical micro-veggies garden on ... instant demand for the product – with nearly 2,000 consumers (and counting) already ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... at the Advanced ERISA Benefit Claims Litigation seminar in Chicago, Illinois. She ... Record, The majority of cases litigated under ERISA involve claims for long-term disability ...
(Date:3/24/2017)... ... March 24, 2017 , ... Gastro Health ... partnership to prep patients for colonoscopy at the HyGIeaCare® Center that is to ... Miami, FL. , The HyGIeaCare® Prep, cleared by the U.S. Food ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... March 27, 2017  PhaseRx, Inc. (NASDAQ: PZRX), ... inherited liver diseases in children, today reported financial ... ended December 31, 2016 and provided an update ... continued to make progress during the fourth quarter ... from our non-human primate safety study, and with our ...
(Date:3/27/2017)... HAMILTON, N.J. , March 27, 2017 ... company and leading in vivo pharmacology contract ... Solar Farm adjacent to its newly expanded preclinical research ... The solar farm provides a cleaner, renewable energy source ... on the environment. Completion of the Genesis Solar Farm ...
(Date:3/24/2017)... , March 24, 2017 According to a new report ... and Industry Forecast, 2014-2022," the spine bone stimulators market was valued at $562 ... at a CAGR of 3.6% during the forecast period. ... ... Research Logo ...
Breaking Medicine Technology: