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Scientists Identify Previously Undetected Drug-resistant Forms of HIV

detect rare viral mutations is a crucial research tool to better understand the early stages of HIV drug resistance, he added.

According to Dr. Kozal, the current genotypic resistance technology available to clinicians may miss many low-level resistant HIV strains that can grow rapidly under drug selection pressure and lead to therapy failure, as it is limited to detecting resistance mutations that are present at levels of approximately 20 per cent or greater in the circulating viral population in a patient.

This study clearly shows that resistance HIV strains present at the one percent level can lead to premature failure of therapy. It is our hope that in the future, clinicians can use this knowledge to better choose antiretroviral drug combinations that have the ability to suppress these resistant HIV strains, leading to better clinical responses in patients, he said.


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