Navigation Links
Scientists Identify New Possible 'biomarker' for Pancreatic Cancer

University of Cincinnati researchers have identified a specific cell receptor, which they say is a potential biological target for pancreatic cancer.

Led by Dr. Andrew Lowy and Dr. Susan Waltz, the study found that the RON receptor tyrosine kinase was "over-expressed" in pancreatic cancer cells, suggesting that the receptor may also contribute to the disease's development.

The researchers say that their findings, published in the journal Cancer Research, may help scientists better understand and treat the disease that kills more than 33,000 people each year.

Published in the journal Cancer Research, this is the first study to establish the link between the RON receptor and pancreatic cancer. The report also tells that receptor tyrosine kinases are proteins on the cell surface used to activate specific body functions like cell growth and migration.

"A normal pancreas has very low levels of RON, but our study showed that as tumours progress, so does the level of RON expression in the pancreas cells -- and those over expressed levels were maintained in 'metastases,' the areas that the tumours spread to," explains Waltz, Associate Professor and Director of the Oncology Research Program, Surgery Department, Cincinnati University.

During the study, the researchers noted that the RON receptor was active in 93 per cent of pancreatic intraepithelial neoplasia, an early form of pancreatic duct cancer. They also observed that the receptor was present in 79 per cent of primary pancreatic cancers, and 83 per cent of metastatic cancers.

Waltz believes that the RON receptor's signalling pathways may be a key factor contributing to pancreatic cancer progression, and that it may give drug developers a new target for RON directed therapies that are more effective in treating the deadly disease.

"When cells became invasive, we saw higher levels of RON expression that correlated with the aggressive nature of this disease and cancer metastasis. Clearly, this signaling pathway is associated with pancreatic cancer and merits further investigation," Waltz said.

During the study, the researchers used the protein HGFL to activate the RON receptor.

They observed that though stimulating the RON receptor had no effect on pancreatic cell growth, blocking it with targeted antibodies killed more cancer cells than did the standard treatment drug gemcitabine alone.

"Our findings suggest that combining antibodies that block the RON receptor and the standard chemotherapy drugs might stop progression of pancreatic cancer more effectively. RON could be a promising molecular target for future cancer drug development," says Waltz.

However, the researchers, who had reported in December last year the association between the RON receptor and breast cancer, say that further studies is needed before blockers for the RON receptors may be used for human testing.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s premier ... of the shoulder pad. The shoulder pad provides optimal support and full contact ... using cold therapy. By utilizing ice and water that is circulated from an insulated ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa ... contributed a medical article to the newly revamped Cosmetic Town journal ... the hair transplant procedure known as Follicular Unit Extraction (FUE). , ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... named one of Michigan’s 2017 Best and Brightest in Wellness® by Best and ... Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. ...
(Date:10/12/2017)... Washington, D.C. (PRWEB) , ... October 12, 2017 ... ... Company, Cal Dining at the University of California Berkeley, and other leading institutions ... leverages the buying power of institutions to change the way animals are raised ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, the ... by Walgreens and pharmacy benefit manager Prime Therapeutics LLC ... brand, which included the unveiling of new signage at ... as well as at a few other company-owned facilities ... brand to patients, some of whom will begin to ...
(Date:10/2/2017)... 2017 The Rebound mobile app is poised to ... the tide of prescription drug addiction. The app empowers users ... and stepping down their dosage in a safe, controlled manner ... 2017; the first 100,000 people to sign up will enjoy ... ...
(Date:9/28/2017)... Sept. 28, 2017 Cohen Veterans Bioscience and ... use of wearable and home sensors for real-time monitoring ... Signal Foundation, a nonprofit organization focused on disruptive health ... an affordable analytical system to record and integrate behavioral, ... ...
Breaking Medicine Technology: