Navigation Links
Scientists Identify Critical Gene Factor in Heart Development

Researchers announced that they have identified a critical genetic factor in the control of many aspects of heart form and function. Scientists have successfully deleted a genetic factor// , called a microRNA, in animal models to understand the role it plays in cardiovascular differentiation and development.

MicroRNAS, or miRNAs, seem to act as rheostats or "dimmer switches" to fine-tune levels of important proteins in cells. To learn how microRNAs do this, the team led by Dr. Srivastava, deleted the gene responsible for one microRNA in mice and examined the effects of its loss on heart development and maintenance. "Knocking out" a gene is a favorite method for figuring out what a particular gene does in a cell by selectively removing it.

"Development of the heart requires very careful regulation of many factors, and that's one reason that microRNAs are so exciting to us," said Dr. Srivastava, GICD Director. "By knocking out the gene for one miRNA, we could determine exactly what it contributes to that complex process."

MicroRNAs exert their control by stopping protein production after the genes have directed them to be made. Previously, it was thought that all the control was at the level of the genes. Although only 20-22 nucleotides long, the microRNAs bind to the much longer messenger RNAs and prevent their blueprint for building a protein from being used. They typically prevent many messenger RNAs from making proteins and therefore can affect myriad events.

The Gladstone team looked at one particular microRNA, miR-1-2, that was active specifically in the heart. A closely related and redundant microRNA miR-1-1 could not fully compensate for loss of miR-1-2. The team found that loss of miR-1-2 affected many functions in the heart, including heart morphogenesis and control of the number of cells in the heart. For example, half of the mice developed holes in the pumping chambers of the heart, which is the most comm
'"/>




Page: 1 2

Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists Identify Critical Gene Factor Heart Development

(Date:7/11/2014)... The American Association of Poison Control ... are commending Senator Bill Nelson (D-FL) for his introduction ... on July 10, 2014. Along with fellow Senate co-sponsors, ... (CPSC) to enact rules requiring safer, child-resistant packaging for ... Senate co-sponsors of the bill include: Sen. Richard Blumenthal ...
(Date:7/11/2014)... Ticket Down reports that tickets to the Argentina ... Cup Match between Brazil and Netherlands are in ... Saturday, July 12th at Estadio Nacional de Brasilia Mane Garrincha ... on Sunday, July 13th at Estadio Jornalista Mario Filho - ... 2014 World Cup are guaranteed to be authentic and are ...
(Date:7/11/2014)... Butler Mobility has recently updated the paint color choices for ... the two standard colors were beige and brown. Butler ... standard colors at no additional charge! These colors will ... the beauty of the stairway. Homeowners will find a ... décor. , The new selection of standard colors is: , ...
(Date:7/11/2014)... the lowest incomes may have a higher risk for a ... suggests. People with PAD have narrowing of the arteries ... The condition causes leg pain and is often an indicator ... PAD have a higher risk for heart disease and stroke. ... who took part in the U.S. National Health and Nutrition ...
(Date:7/11/2014)... Volunteers from Scientology Churches ... week with drug education lectures, forums and conferences, information ... cities around the world. , Drug abuse is an ... Drug Abuse, abuse of alcohol and illicit drugs costs ... work, decreased productivity and healthcare. , In the ...
Breaking Medicine News(10 mins):Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 3Health News:Argentina vs. Germany World Cup Finals Tickets & Brazil vs. Netherlands 3rd Place World Cup Tickets Are in Huge Demand 2Health News:Butler Mobility Products Announces Five New Standard Colors for Their Inclined Platform Lifts 2Health News:Poor More Prone to Leg Circulation Trouble 2Health News:Scientologists Taking Action against Drug Abuse 2Health News:Scientologists Taking Action against Drug Abuse 3
... ... Group in Boston, at The Liberty Hotel today, which for the first time includes ... to connect and exchange data with other applications. , ... Boston, Massachusetts (Vocus) October 20, 2009 -- ...
... RICHMOND, Calif., Oct. 20 ... the presentation of top-line, statistically significant Phase 2 clinical ... as a treatment for diabetic neuropathy (DN) at the ... Top-line data from Sangamo,s SB-509-601 Phase 2 clinical trial ...
... 20 In testimony to a U.S. House of ... ways to better meet the needs of every community ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20090108/RedCrossLOGO ) , Trevor Riggen, Red ... to how the Red Cross is meeting the needs ...
... advanced liver disease who drink three or more cups of ... disease progression than non-coffee drinkers according to a new study ... Institute (NCI). The study found that patients with hepatitis ... standard disease treatment benefited from increased coffee intake. An ...
... Sponsor Event to Earn the World Record for the Most Massages ... On Sunday, October 25, Massage Envy will sponsor an event ... massaged simultaneously in one location. The goal is to have ... 34th annual Marine Corps Marathon. There will be a sea ...
... (HCC) or primary liver cancer forms in the epithelial tissue ... hepatitis B virus (HBV) or hepatitis C virus (HCV). ... 15,000 men and 6,000 women are diagnosed with HCC each ... highest regions being Western Pacific and Africa according to a ...
Cached Medicine News:Health News:Orion Health™ Rhapsody User Group 2009, Boston Starts Today,New Interoperability Expo Helps Ignite Record Attendance 2Health News:Orion Health™ Rhapsody User Group 2009, Boston Starts Today,New Interoperability Expo Helps Ignite Record Attendance 3Health News:Orion Health™ Rhapsody User Group 2009, Boston Starts Today,New Interoperability Expo Helps Ignite Record Attendance 4Health News:Sangamo BioSciences Announces Presentation of Top-Line Statistically Significant Phase 2 Data in Diabetic Neuropathy at Society for Neuroscience Meeting 2Health News:Sangamo BioSciences Announces Presentation of Top-Line Statistically Significant Phase 2 Data in Diabetic Neuropathy at Society for Neuroscience Meeting 3Health News:Sangamo BioSciences Announces Presentation of Top-Line Statistically Significant Phase 2 Data in Diabetic Neuropathy at Society for Neuroscience Meeting 4Health News:Sangamo BioSciences Announces Presentation of Top-Line Statistically Significant Phase 2 Data in Diabetic Neuropathy at Society for Neuroscience Meeting 5Health News:Sangamo BioSciences Announces Presentation of Top-Line Statistically Significant Phase 2 Data in Diabetic Neuropathy at Society for Neuroscience Meeting 6Health News:Sangamo BioSciences Announces Presentation of Top-Line Statistically Significant Phase 2 Data in Diabetic Neuropathy at Society for Neuroscience Meeting 7Health News:Sangamo BioSciences Announces Presentation of Top-Line Statistically Significant Phase 2 Data in Diabetic Neuropathy at Society for Neuroscience Meeting 8Health News:Red Cross Strives to Help Disaster's Vulnerable Population 2Health News:Red Cross Strives to Help Disaster's Vulnerable Population 3Health News:Drinking coffee slows progression of liver disease in chronic hepatitis C sufferers 2Health News:Record-Breaking Relaxation at Marine Corps Marathon 2Health News:Scientists identify specific markers that trigger aggressiveness of liver cancer 2
(Date:7/11/2014)... 11, 2014 On Thursday, ... 0.52%, the Dow Jones Industrial Average finished the day 0.42% ... down 0.41%. The losses were broad based as eight out ... 500 Health Care Sector Index ended the day at 711.88, ... last one month. Investor-Edge has initiated coverage on the following ...
(Date:7/11/2014)... 2014 Neurelis, Inc. ("Neurelis") today announced an ... option held by Biotie to purchase Neurelis, clearing the ... (intranasal diazepam) for pediatric and adult epilepsy patients who ... year, Biotie has advanced the development program for NRL-1 ... clinical work required for NDA submission to the FDA.  ...
(Date:7/10/2014)... Integrated Silicon Solution, Inc. (Nasdaq: ... IC solutions, today announced that it will host its ... 7:00 a.m. Pacific Time (10:00 a.m. Eastern Time) to ... third quarter ended June 30, 2014. To ... 6:50 a.m. Pacific time on July 24, 2014.  The ...
Breaking Medicine Technology:Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3
... Nov. 15, 2011 Reportlinker.com announces that ... in its catalogue: ... India & China ... emerging economies represent a combined pharmaceutical market ...
... Pa, Nov. 15, 2011 As any purchasing manager knows, ... shipping options is time lost. When purchasing surgical instruments ... In January of 2010, Robert Edelstein, President of Millennium ... Saints Charities seeking a vendor for eye surgical instruments ...
Cached Medicine Technology:The Outlook for Pharmaceuticals in Brazil, Russia, India & China 2The Outlook for Pharmaceuticals in Brazil, Russia, India & China 3The Outlook for Pharmaceuticals in Brazil, Russia, India & China 4The Outlook for Pharmaceuticals in Brazil, Russia, India & China 5Millennium Surgical Corp. Provides Instruments to Latter Day Saints Charities for Humanitarian Projects 2
Hard protective shields for post-operative or post-injury use. Universal, or Left/Right specific. Packaged 12 per box....
Hard protective shields for post-operative or post-injury use. Universal, or Left/Right specific. Packaged 12 per box....
Hard protective shields for post-operative or post-injury use. Universal, or Left/Right specific. Packaged 12 per box....
... The Wet-Field Coagulator provides precise episcleral, ... peripheral tissue trauma. Controlled Rf diathermy ... comprehensive line of bipolar Eraser instruments, ... enhanced features that ensure a high ...
Medicine Products: