Navigation Links
Scientists Identify Cancer Pathway

Scientists in the US have identified a pathway that allows cancer to spread from one part of the body //to other, a development they say may help to understand the disease better.

Jun-Lin Guan, a professor in the department of molecular medicine in the College of Veterinary Medicine at Cornell University, used a cultured cell line to study cancer, reports the university's website.

They used these cells to create a model system for cancer cells, which means its basic pathway exists in real-world systems while the actual proteins that act on the system may vary.

In the model system, the researchers discovered critical differences between cancer cells and normal cells regarding a mechanism called endocytosis -- which cells employ to let materials enter through the cell membrane, the report said. They used a protein called v-Src derived from an oncogenic virus, which has the ability to transform a normal cell into one with many features resembling those found in cancer cells.

While this virus has not been found in humans, it does lead to tumour growth in chickens and created cancerous cells in the cultured system. In the study, they found that v-Src attaches to an enzyme, called focal adhesion kinase, inside the cell.

This association jumpstarts a series of cascading interactions between proteins in the cell that ultimately block some cell-surface proteins from entering through the cell's membrane.

One of the proteins not allowed entry is called MT1-MMP. As this material accumulates on the cell surface, it degrades the connective tissue that holds the cancerous cell in place. The build-up of MT1-MMP also activates an enzyme called MMP2, which further degrades the connective tissue. In this way, the cancer cell loses its moorings and can float off to spread around the body. While no one has found v-Src in human cancer patients, a number of other cancers have been linked to viruses, including the herpe s virus and its association with cervical cancer.

The study reveals how connective tissue holding a cancer cell in place might degrade, unmooring the diseased cell and allowing it to spread to other parts of the body. "We looked at a relatively late stage of cancer and its spread within the body," Guan said. "The spreading part is less well understood, and it's the spreading that is killing people."

Source: IANS

Medindia on Cancer: Further information

Cancer: Cancer occurs when cells divide in an uncontrolled manner. In the human body, a process called cell division, constantly replaces the cells in the tissues that are lost. Normally, cells divide and produce the exact number of cells required. In cancer, cells divide for no apparent reason and form a mass of extra tissue becoming big enough to be noticed as a growth or tumor.

For more information ead:

http://www.medindia.com/patients
/patientinfo/breastcancer_about.htm


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CHAPEL HILL, N.C. , June 24, 2016 ... in healthcare decisions and regulators/payers have placed more ... this new environment, patient support programs in the ... support for patients, medications. Consequently, pharmaceutical companies are ... to ensure they are providing products and services ...
(Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
Breaking Medicine Technology: