Navigation Links
Scientists Identify Antibodies That Block Human and Animal SARS Viruses

Scientists have for the first time identified human antibodies that can neutralise different strains of the virus responsible for the outbreaks of severe acute respiratory syndrome (SARS).

Working with collaborators from the United States Army Medical Research Institute of Infectious Diseases (USAMRIID), scientists at the National Institutes of Health conducted in vitro experiments on a mouse model to test the neutralizing activity of the antibodies.

The researchers say that the new findings are important because animal strains of the virus may be capable of triggering a future human outbreak.

"This study is important because the viral strain that caused the outbreak in people in 2002 probably no longer exists in nature," explains Dr. Kanta Subbarao of the National Institute of Allergy and Infectious Diseases (NIAID), whose laboratory verified the efficacy of the anti-SARS antibodies in animal models.

"What we need to prove for any vaccine, therapeutic, antibody, or drug is that it is effective not only against the strain of SARS virus isolated from people, but also against a variety of animal strains, because animals will be a likely source for re-emergence of the SARS virus," added the alumna of Madras University.

The researchers identified two human antibodies that bind to a region on the SARS virus' spike glycoprotein that is called the receptor binding domain (RBD). One of the antibodies, called S230.15, was found in the blood of a patient who had been infected with SARS and later recovered, while the second antibody, m396, was taken from a library of human antibodies the researchers developed from the blood of 10 healthy volunteers.

When tested in cells in the laboratory, both antibodies potently neutralized samples of the virus from the two SARS outbreaks that occurred in 2002-2003 and 2003-2004.

The antibodies also neutralized samples of the virus taken from w ild civets, a cat-like mammal in which strains of the virus were found during the outbreaks, although with lower potency.

The researchers say that the antibodies have also been found effective in protecting against human and animal SARS viruses in experiments on mice.

"This antibody neutralizes all strains of SARS we tested and is likely to neutralize all strains of the virus with known sequences. There are no other reports for such antibodies available," said lead researcher Dr. Dimiter S. Dimitrov.

The discovery of two effective antibodies has the advantage that a newly emergent variation of the SARS coronavirus might be insensitive to neutralization with one, but still susceptible to the other.

"Our results demonstrate novel potential antibody-based therapeutics against SARS that could be used alone or in combination...these human antibodies could be also used for diagnosis and as research reagents in the development of vaccines and inhibitors," summarized the authors.

The study has been published in the online edition of the Proceedings of the National Academy of Sciences.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Global law ... magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition are ... , Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Consumers have taken a more ... placed more emphasis on patient outcomes. ... in the pharmaceutical industry have evolved beyond just ... companies are focusing on becoming more patient-oriented across ... and services that improve health. ...
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
Breaking Medicine Technology: