Navigation Links
Scientists Identify Antibodies That Block Human and Animal SARS Viruses

Scientists have for the first time identified human antibodies that can neutralise different strains of the virus responsible for the outbreaks of severe acute respiratory syndrome (SARS).

Working with collaborators from the United States Army Medical Research Institute of Infectious Diseases (USAMRIID), scientists at the National Institutes of Health conducted in vitro experiments on a mouse model to test the neutralizing activity of the antibodies.

The researchers say that the new findings are important because animal strains of the virus may be capable of triggering a future human outbreak.

"This study is important because the viral strain that caused the outbreak in people in 2002 probably no longer exists in nature," explains Dr. Kanta Subbarao of the National Institute of Allergy and Infectious Diseases (NIAID), whose laboratory verified the efficacy of the anti-SARS antibodies in animal models.

"What we need to prove for any vaccine, therapeutic, antibody, or drug is that it is effective not only against the strain of SARS virus isolated from people, but also against a variety of animal strains, because animals will be a likely source for re-emergence of the SARS virus," added the alumna of Madras University.

The researchers identified two human antibodies that bind to a region on the SARS virus' spike glycoprotein that is called the receptor binding domain (RBD). One of the antibodies, called S230.15, was found in the blood of a patient who had been infected with SARS and later recovered, while the second antibody, m396, was taken from a library of human antibodies the researchers developed from the blood of 10 healthy volunteers.

When tested in cells in the laboratory, both antibodies potently neutralized samples of the virus from the two SARS outbreaks that occurred in 2002-2003 and 2003-2004.

The antibodies also neutralized samples of the virus taken from w ild civets, a cat-like mammal in which strains of the virus were found during the outbreaks, although with lower potency.

The researchers say that the antibodies have also been found effective in protecting against human and animal SARS viruses in experiments on mice.

"This antibody neutralizes all strains of SARS we tested and is likely to neutralize all strains of the virus with known sequences. There are no other reports for such antibodies available," said lead researcher Dr. Dimiter S. Dimitrov.

The discovery of two effective antibodies has the advantage that a newly emergent variation of the SARS coronavirus might be insensitive to neutralization with one, but still susceptible to the other.

"Our results demonstrate novel potential antibody-based therapeutics against SARS that could be used alone or in combination...these human antibodies could be also used for diagnosis and as research reagents in the development of vaccines and inhibitors," summarized the authors.

The study has been published in the online edition of the Proceedings of the National Academy of Sciences.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect Plugin ... whole new perspective by using the title layers in ProSlice Levels to split-up ... Levels contains over 30 Different presets to choose from. FCPX users can ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... Markets has announced the addition of the " ... offering. This ... and provides an updated review, including its applications in ... the total market, which includes three main industries: pharmaceutical ...
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
(Date:6/24/2016)... Calif. , June 24, 2016  American Respiratory Labs (ARL), ... is now able to perform sophisticated lung assessments in patients, homes, ... , Inc. Patients are no longer limited to ... EasyOne PRO ® , ARL patients like Jeanne R. of ... in the comfort of her own home. ...
Breaking Medicine Technology: