Navigation Links
Scientists Identify "master Switch" for Brown Fat in Mice

Scientists have identified a "master switch" for the production of brown fat, a type of adipose tissue that generates heat and counters obesity caused by overeating , by conducting experiments on mice.

Dr. Bruce Spiegelman of Dana-Farber Cancer Institute believes that turning up the equivalent switch in humans may be a new strategy for treating obesity.

The researchers are now planning to rev up the control in mice and overfeed them to see if they are resistant to becoming obese.

"Brown fat is present in mice and in human infants, where it keeps them warm by dissipating food energy as heat, instead of storing it as white fat," said Dr. Spiegelman, senior author of the paper published in the journal Cell Metabolism.

"Human adults don't have much brown fat, but there is some, and from a therapeutic perspective the question is whether that pathway can be reactivated," he added.

Dr. Spiegelman revealed that the pathway is controlled by a gene called PRDM16, found in brown but not in white fat, which stores excess calories and causes waistlines to bulge.

In some mouse experiments, the researcher inserted PRDM16 genes into precursors of white fat, and implanted the white fat precursors under the skin of the animals. The PRDM16 gene coaxed those cells to generate brown fat cells.

"These results illustrate that the gene we identified can turn on a broad program of brown fat cell development when we insert it into precursors that otherwise would produce white fat," Dr. Spiegelman said.

Upon further analysis, the researcher observed that PRDM16 triggered formation of brown fat cells in part by turning on a metabolic pathway controlled by PGC-1alpha and the gene UCP1, which allows cells to release large amounts of energy as heat.

The researchers believe that engineering cells with PRDM16 may work as obesity preventive in humans, if their continued research in mice shows promising results once again.

"You might not have to implant a large amount of engineered precursors in people who are at risk for being obese. In theory, you would only have to reduce the accumulation of white fat by 1 percent or so to have an effect," said Dr. Spiegelman.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... ... Quality metrics are proliferating in cancer care, and are derived from many of ... beholder, according to experts who offered insights and commentary in the current issue of ... full issue, click here . , For the American Society of Clinical Oncology ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer ... through a fitness app. The fitness app plans to fix the two major problems leading ... a one size fits all type program , They don’t eliminate all the ...
(Date:6/25/2016)... ... ... closing of Bruton Memorial Library on June 21 due to a possible lice infestation, as ... of head lice: the parasite’s ability to live away from a human host, and to ... one in the event that lice have simply gotten out of control. , As lice ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
(Date:6/24/2016)... BEIJING , June 24, 2016 Dehaier ... or the "Company"), which develops, markets and sells medical ... China , signed a strategic cooperation agreement with ... as "Hongyuan Supply Chain") on June 20, 2016, to ... Under the strategic cooperation agreement, Dehaier will leverage Hongyuan ...
Breaking Medicine Technology: