Navigation Links
Scientists Identified Obesity Control Switch

Researchers at Dana-Farber Cancer Institute have identified a long-sought "master switch" in mice for the production of brown fat , a type of adipose tissue that generates heat and counters obesity caused by overeating.

A team headed by Bruce Spiegelman, PhD, suggests in the July issue of Cell Metabolism that turning up the equivalent switch in people might be a new strategy for treating overweight and obesity. The investigators said their next step is to rev up the control in mice and overfeed them to see if they are resistant to becoming obese.

"Brown fat is present in mice and in human infants, where it keeps them warm by dissipating food energy as heat, instead of storing it as white fat," said Spiegelman, senior author of the paper. "Human adults don't have much brown fat, but there is some, and from a therapeutic perspective the question is whether that pathway can be reactivated."

The pathway, according to the new report, is controlled by a gene and protein known as PRDM16 that is found in brown but not in white fat -the type that stores excess calories and causes waistlines to bulge.

In some of the mouse experiments, the Dana-Farber investigators inserted PRDM16 genes into precursors of white fat, and implanted the white fat precursors under the skin of the animals. The PRDM16 gene coaxed those cells to generate brown fat cells.

"These results illustrate that the gene we identified can turn on a broad program of brown fat cell development when we insert it into precursors that otherwise would produce white fat," Spiegelman added. Lead author on the paper is Patrick Seale, PhD, in the Spiegelman lab.

Further analysis showed that PRDM16 triggered formation of brown fat cells in part by turning on a metabolic pathway controlled by PGC-1alpha, which was discovered in Spiegelman's lab, and the gene UCP1, which allows cells to release large amounts of energy as heat.

If continued research demonstrates that engineering fat precursor cells with PRDM16 and implanting them in mice works as an obesity preventive, the investigators say a similar intervention is theoretically possible in people.

"You might not have to implant a large amount of engineered precursors in people who are at risk for being obese," said Spiegelman, who is also a professor of cell biology at Harvard Medical School. "In theory, you would only have to reduce the accumulation of white fat by 1 percent or so to have an effect."


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/19/2017)... ... January 19, 2017 , ... With the cold weather here, many people will have ... are efficient when clearing large amounts of snow, but they can be dangerous when used ... Consumer Product Safety Commission for the proper use of snow blowers:, , ...
(Date:1/19/2017)... ... January 19, 2017 , ... Remote ... recently unveiled impressive transportable capabilities with their iMedHD2™ Portable Teleultrasound System. ... to RMT technology that delivers HD, dynamic, streaming ultrasound images and video to ...
(Date:1/19/2017)... NJ (PRWEB) , ... January 19, 2017 , ... ... certified dermatologist by the American Board of Dermatology and fellowship trained Mohs and ... the National Institutes of Health, Dr. Li completed his internship in internal medicine ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... Students interested ... Tissue Donation Awareness Scholarship competition., The winner will earn a $1,000 scholarship and have ... competition begins Feb. 1, and the deadline is May 31, with the winner announced ...
(Date:1/19/2017)... ... January 19, 2017 , ... Allegheny Health Network (AHN) officials today announced a ... the Network’s programs and services in the greater Pittsburgh region. Starting January 23, patients ... offered one for that same afternoon. , AHN is the first ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 19, 2017 The U.S. Food and Drug Administration ... Constipation (CIC) in adult patients. "No one ... said Julie Beitz , M.D., director of the Office ... Evaluation and Research. "With the availability of new therapies, patients ... their condition." ...
(Date:1/19/2017)... -- Stealth BioTherapeutics Inc. ( Stealth ), a clinical-stage biopharmaceutical ... new additions to its senior leadership team: W. ... Daniel Geffken as interim Chief Financial Officer. ... Pharm.D. has been promoted to Chief Clinical Development Officer. ... and Daniel to our management team, as both will ...
(Date:1/19/2017)... 19, 2017 James ... & Haematology, 2016;12(Suppl 2):3-8; http://www.touchoncology.com/articles/optimising-clinical-outcomes-gastrointestinal-cancers-through-inhibiting-angiogenesis-and ... ... Published recently in a supplement to European ... touchONCOLOGY, an article by James Gilbart ...
Breaking Medicine Technology: