Navigation Links
Scientists Find Single Circuit Channeling Depression in Rats

Scientists and doctors long baffled by the multiple causes and brain processes for depression may now have a single "holy grail" brain pathway to focus on for treatment, according to a new research study released Thursday.

Studying the brains of rats, researchers at the Stanford University School of Medicine have discovered a single brain circuit that appears to funnel all the mechanisms and treatments of depression.

Depression-related behavior is manifested in changes in electrical signals moving through the circuit, according to the study released on the journal Science's website.

Karl Deisseroth, a professor of bioengineering and of psychiatry and behavioral sciences, said the circuit can help explain why there can be many causes and treatments of depression.

"It also helps us understand conceptually how something that seems as hard to get traction on as depression can have a really quantitative, concrete basis," he said in a summary of the study.

Deisseroth led a research team to see if they could demonstrate how malfunctions in brain circuitry could be at the root of depression.

They studied the electrical activity of still-active slices of the hippocampus section of rat brains treated with flourescent dye, using high-speed high-resolution cameras to record activity in brain neurons in real time.

According to Deisseroth, rat brains show similar depression symptoms to human ones and react to anti-depression medicines in the same way.

The testing showed that an alteration in electrical activity flow through the brain could be readjusted with the use of human drugs against depression -- suggesting the existence of a specific circuit for the condition.

According to Deisseroth, the discovery of the single circuit for depression could lead to methods doctors could use to better diagnose and quantify the problem in their human patients.
"The holy grail of psychiatry is to try to find final common pathways that can make sense of how genes and life experiences end up with the same result," he said.

"And the same goes for medications. There are many treatments that act in fundamentally different ways -- how do we make sense of all that complexity?"


Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:

(Date:10/13/2015)... ... October 13, 2015 , ... "My friend's son suffers from ... his infected cheeks," said an inventor from Platteville, Colo. "I came up with this ... He developed the UNTOUCHABLE to prevent a child from rubbing or scratching his or ...
(Date:10/13/2015)... ... ... According to an article published October 5th by the American ... weight with a bariatric procedure are much less likely to develop endometrial cancer, which ... from 40 to 50 percent of all endometrial cancer cases are caused by obesity, ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... IBM software products, introduced a new company, RightSensor™ LLC, an Internet of Things ... capability. RightSensor™ provides a fully-managed approach for customers requiring sensor hardware for ...
(Date:10/13/2015)... , ... October 13, 2015 , ... e-con Systems Inc., ... today announced See3CAM_CU40, the industry’s first RGB-IR pixel format camera with a ... new member of e-con’s See3CAM family of UVC USB 3.0 cameras, is based on ...
(Date:10/13/2015)... ... , ... Protein is essential to good health. You need it to make ... much protein does the average man need in order to stay healthy? , ... issue of Harvard Men's Health Watch . Most Americans get about 15% of ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , October 13, 2015 ... World Thrombosis Day Interactive Infographic   --> ... World Thrombosis Day  to promote vital global awareness ... and symptoms. Thrombosis is the formation of potentially ... - resulting in venous thromboembolism (VTE) - or the ...
(Date:10/12/2015)... Given the intricacy of the anatomy and physiology of ... drug effectively to a specific ocular site. Several barriers have ... include dilution of a drug by tears, clearance of a ... issues with respect to the cornea, sclera and choroid. Approximately ... due to the aforementioned barriers. --> Given ...
(Date:10/12/2015)... 12, 2015  The Pharmacy Compounding Accreditation Board ... Pharmacy in Costa Mesa , ... the pharmacy,s commitment to meeting and/or exceeding national ... --> --> ... --> --> Harbor Compounding ...
Breaking Medicine Technology: