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Scientists Find Clue for the Prevalence of Bladder Cancer More in Men

er, even without the hormones. The team has shown in other studies that even female hormones such as estrogen can turn on the androgen receptor.

"The activity of the androgen receptor is different from the activity of hormones that target the receptor," said Chang. "We've shown very clearly that even without these hormones, the receptor is still active in the development of cancer. This is crucial information as doctors seek to develop treatments for diseases like prostate or bladder cancer in men."

To knock out the androgen receptor, the team used a compound known as ASC-J9, a synthetic chemical compound that is loosely based on a compound found in curcumin. Chang's laboratory, in collaboration with San Diego-based AndroScience Corp., has screened hundreds of compounds for their activity involving the androgen receptor. Just last month, the team showed that ASC-J9 offers promise against a rare neuromuscular disease known as Kennedy's disease.

The compound is now being tested as a cream to treat acne in a clinical trial run by AndroScience, a biotech company founded by Chang, Charles C-Y Shih, and Por-Hsiung Lai in 2000. The University owns a stake in the company, which has licensed several of Chang's research findings.

Source-Eurekalert
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