Navigation Links
Scientists Equip Bacteria With Custom Chemo-Navigational System

Using an innovative method to control the movement of Escherichia coli in a chemical environment, Emory University scientists have opened the door to powerful new opportunities in drug delivery, environmental cleanup and synthetic biology. Their findings are published online in the Journal of the American Chemical Society and will be published in a future print issue.

Justin Gallivan, PhD, assistant professor of chemistry, and graduate student Shana Topp successfully reprogrammed E. coli's chemo-navigational system to detect, follow and precisely localize to specific chemical signals. In doing so, the scientists exploited E. coli's natural chemotaxis, a microbe's ability to move toward specific chemicals in its environment.

'Equipping bacteria with a way to degrade pollutants, synthesize and release therapeutics, or transport chemicals with an ability to localize to a specific chemical signal would open new frontiers in environmental cleanup, drug delivery and synthetic biology,' says Dr. Gallivan.

The researchers equipped E. coli with a 'riboswitch,' a segment of RNA that changes shape when bound to certain small target molecules, which can then turn genes on or off. Dr. Gallivan and Topp believe that the riboswitch can be used to equip other types of self-propelled bacteria with 'chemo-navigation' systems to move them toward desired targets.

Chemotactic bacteria navigate chemical environments by coupling their information-processing capabilities to powerful, tiny molecular motors that propel the cells forward.

Researchers have long envisioned reprogramming bacteria so that microbes capable of synthesizing an anti-cancer drug, for instance, can be used to target diseased cells while sparing healthy cells of side effects. Likewise, scientists are researching ways to use bacteria to clean up oil spills or remove other pollutants from soil, water and wastewater.

'This new ability to e quip motile bacteria with a precise and tunable chemo-navigation system will greatly enhance the impressive arsenal of natural and engineered cell behaviors,' says Dr. Gallivan.


Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:

(Date:11/27/2015)... ... November 27, 2015 , ... ... innovative online platform for mental health and wellness consultation, has collaborated with a ... will bridge the knowledge gap experienced by parents and bring advice from parenting ...
(Date:11/27/2015)... ... , ... Avid collector, Andrew Hawley from Vintage Rock Posters, announces his search ... one of Joplin's most famous and beautiful concert posters. The concert was held on ... Arbor. The According to Hawley, "It is hard to believe that Joplin's stardom was ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... ... a real-time eReferral system for diagnostic imaging in the Waterloo region. Using the ... and Nuclear Medicine tests directly from their electronic medical record (EMR) without the ...
(Date:11/26/2015)... Antonio, TX (PRWEB) , ... November 26, 2015 , ... ... On November 19, 2015, our surgeons performed their 6,000th free flap breast reconstruction ... , “We wake up every day excited to rebuild lives and it’s an honor ...
(Date:11/26/2015)... ... 2015 , ... Indosoft Inc., developer and distributor of the world-class Asterisk based ... efficiency and reliability. , The new Q-Suite 6 platform is based on the latest ... itself into a specific piece of software for many key components of the suite. ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 ... "Radioimmunoassay Market by Type (Reagents & ... Academics, Clinical Diagnostic Labs), Application (Research, Clinical ... 2020" report to their offering. ... addition of the "Radioimmunoassay Market by ...
(Date:11/25/2015)... , Nov. 25, 2015  The American ... and Gynecologists (ACOG), and the March of Dimes ... Protecting Our Infants Act of 2015 ... number of newborns born exposed to drugs, such ... the bill,s introduction, all three organizations have worked ...
(Date:11/25/2015)... MELVILLE, N.Y. , Nov. 25, 2015  Henry ... products and services to office-based dental, medical and animal ... Dental (GNYDM) Meeting the Henry Schein ConnectDental® Pavilion ... industry,s broadest array of open solutions designed to help ... Click here for a schedule of ...
Breaking Medicine Technology: