Navigation Links
Scientists Enlist Worms to Discover New Therapies for Huntington’s Diseas

Scientists from UAH are working with the U.S army to find clues that may help to build therapies for// Huntington’s disease.

Lead researcher Dr. Lynn Boyd, an associate professor of biology at UAH has enlisted the help of an army of worms to find out what effect certain enzymes will have, on the clusters of amino acids associated with Huntington’s disease.

The experiment is being carried out at the Army's Primary Standards Laboratory at Redstone Arsenal.

While it is not known if these clumps are good or not (scientists think it might be a way of the cell removing bad amino acids out of the way), the team has discovered some enzymes which make the clumps bigger, and some which make it smaller.

The worms come into the picture when the scientists attach glowing proteins derived from jellyfish to certain enzymes, which are then tagged onto the chromosomes of the worms. They inject the dye-tagged genetic material into the worms before they are zapped by powerful radiation.

At just the right level of radiation, the DNA strands in the worms' unfertilized eggs snap and the dye-tagged material slips into the chromosomes.

The glowing protein is then reproduced in the worm's offspring. If the target material concentrates in clumps it creates glowing spots, giving the UAH researchers a tool for tracking what happens when specific enzymes are suppressed.

The UAH team hoped to tag individual strains of worms for seven specific enzymes.

Using human cells grown in a culture, Boyd found that suppressing the human enzymes that corresponded to the worm enzymes had the same effects on polyglutamine aggregates.

The researchers hope the findings will contribute to therapies aimed at treating Huntington’s disease.

Source-Newswise
AN
'"/>




Page: 1

Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... ... 2016 , ... After enjoying record-breaking attendance at its last ... 33rd Annual Issues & Research Conference, March 2-3, 2017, at the Westin ... is “Persistent Challenges and New Opportunities: Using Research to Accelerate the Dialogue." 2016 ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... a Property owned by an affiliate of Seavest, has won a prestigious national ... Southern Chester County ambulatory care center (ACC) was named “Best New Development, MOBs ...
(Date:12/8/2016)... ... December 08, 2016 , ... With the increasing demand for dental ... Your Mouth?” (WIYM) campaign to inform dentists and patients about the safety issues related ... and prosthetic market in the U.S. is projected to reach $6.4 billion in 2018 ...
(Date:12/8/2016)... ... December 08, 2016 , ... SunView Software aims to redefine ... are both engaging and easy to use. Coming off the heels of a ... today its plans to roll out new AI-powered self-service enhancements to help organizations ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... has been recognized for adherence to the highest standards of trauma, maternity, ... organizations, announced the center's president and CEO, Dr. Daniel Messina. , Among the ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... Dec. 8, 2016 KEY FINDINGS ... share of the market in 2016 and is expected ... be attributed to a large number of surgical procedures ... the largest share in the patient temperature management market.) ... as reducing loss of blood during surgeries, lowering the ...
(Date:12/8/2016)... 8, 2016 Research and Markets has announced the addition ... their offering. ... This report analyzes the worldwide markets for Endodontic Supplies in US$ ... , Japan , Europe , ... World. Annual estimates and forecasts are provided for the period 2015 ...
(Date:12/8/2016)... QUEBEC CITY , Dec. 8, 2016 /PRNewswire/ ... key US patents for improving the accuracy, reproducibility ... CD images in long and small bone orthopaedic ... proprietary approach to creating personalized orthopaedic restorations based ... create personalized orthopaedic restorations, the company harnesses the ...
Breaking Medicine Technology: