Navigation Links
Scientists Discover Non-dietary Therapy For Celiac Diseases

Scientists from the Stanford University and the Celiac Sprue Research Foundation have claimed to discover a non-dietary remedy for the treatment of celiac sprue// that is an inherited inflammatory disorder of the small intestine that affects 1 in 200 people around the world. The two research studies that have been published in the June issue of Chemistry and Biology have opened the way for clinical testing with an oral enzyme therapy that could prevent various symptoms and complications of this widespread disease.

People with celiac sprue, also called celiac disease, cannot tolerate the protein gluten in their diet. Gluten is present in grains like wheat, barley, and rye. When gluten is ingested by a celiac patient, it sets off an inflammatory reaction that damages the small intestine, leading to malabsorption, an autoimmune-like response, and many other complications. The only effective therapy for celiac disease is complete dietary exclusion of gluten. However, the ubiquitous nature of gluten poses a constant threat to celiacs, and a majority of celiac patients who adopt a restrictive diet still exhibit structural and functional gut abnormalities.

"Non-dietary therapies that allow celiac patients to safely incorporate low-to-moderate levels of gluten into their daily diet would be of considerable benefit," explains study leader Dr. Chaitan Khosla, from Stanford University and. "Having demonstrated earlier that certain types of enzymes can detoxify gluten, our laboratory set out to devise an optimal oral enzyme therapy for celiac sprue by borrowing from nature. In germinating barley seed, gluten serves as a nutritious storage protein that is efficiently digested by enzymes. One enzyme, EP-B2, plays a crucial role in this process by breaking gluten proteins after glutamine residues, which comprise one-third of all amino acid residues in gluten."

Dr. Khosla's group used recombinant bacteria to produce a form of EP-B2 that only acti vates under acidic conditions similar to the conditions found in the human stomach. The researchers demonstrated that EP-B2 efficiently digested gluten protein under gastric conditions and, importantly, EP-B2 was most specific for those parts of gluten that are known to trigger celiac pathogenesis. In a second study, the researchers went on to devise an even more potent double enzyme therapy for detoxifying gluten.

EP-B2 was tested in combination with another well-characterized enzyme called PEP that breaks gluten protein after proline residues. Like glutamine, proline is also abundant in inflammatory gluten peptides. At very high gluten loads, where neither PEP nor EP-B2 alone could detoxify gluten quickly enough to prevent inflammation, a PEP and EP-B2 combination completely abolished gluten immunotoxicity within ten minutes under simulated gastric and duodenal conditions.

In this tag-team therapy, EP-B2 first cleaved gluten into small pieces under gastric conditions that were then easier for PEP to fully detoxify under duodenal conditions. "Our results suggest that recombinant EP-B2 should be effective as supportive therapy to help celiacs cope with the 'hidden' gluten in everyday life, and that a two-enzyme cocktail containing PEP and EP-B2 may even allow celiacs to resume a more normal diet in the future," offers Dr. Khosla.

Source: EurekAlert
'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2017)... PA (PRWEB) , ... June 20, 2017 , ... ... assessments and consulting services, has published a new eBook titled “ 5 Questions ... Bridge, MSc, Associate Research Analyst on the Genetic Test Evaluation (GTE) team, the ...
(Date:6/20/2017)... ... June 20, 2017 , ... AMC Health , the leading provider of ... clinical trials market. Similar to its approach in demonstrating positive outcomes in the healthcare ... by proving the value of eVisits to support virtual studies. , In ...
(Date:6/20/2017)... ... June 20, 2017 , ... With certifications and experience that puts them at ... Adam and Hal Kimowitz are currently accepting new patients at their practice for these ... for some patients, which is why they offer the latest in modern dental techniques ...
(Date:6/20/2017)... Fort Lauderdale, FL (PRWEB) , ... June 20, 2017 , ... ... Flex, a new scrub collection featuring seven new products designed to create tailored looks ... a mixture of polyester and cotton easy care stretch twill. , With trendy looks ...
(Date:6/20/2017)... ... June 20, 2017 , ... MEDI+SIGN, a healthcare ... officially welcome Anthony Stanowski, DHA, FACHE to the MEDI+SIGN Advisory Board. , ... in healthcare will provide invaluable direction for the company,” says Andrew Hoffman, President ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... , June 5, 2017 Kohll,s Pharmacy & Homecare is ... the United States . The Raizer is a ... fallen person up to an almost-standing position within ... operated by one assistant and does not require ... enough that a child can operate it, and ...
(Date:6/2/2017)... June 2, 2017  NxStage Medical, Inc. (Nasdaq:  NXTM), a leading ... announced new findings demonstrating positive biochemical outcomes related to ... One™. The data will be presented at the ERA-EDTA ... Madrid, Spain . The research ... Dialysis Network in Europe ...
(Date:5/30/2017)... Israel , May 30, 2017 DarioHealth Corp. (NASDAQ: ... big data solutions, today announced that it will be presenting at ... at 8:00 AM PT. Erez Raphael , CEO, of DarioHealth ... The conference will be held on June 6th & 7th, 2017 ... companies in the small / micro-cap space. ...
Breaking Medicine Technology: