Navigation Links
Scientists Develop Artificial Blood Vessels for Vascular Grafts in Mice

Researchers at the University of Pittsburgh School of Medicine have developed artificial blood vessels, which may have significant implications for the treatment of heart and kidney disorders .

The vessels, made from muscle-derived stem cells (MDSCs) and a biodegradable polymer, exhibit extensive remodelling, and remain free of blockages when grafted into rats.

The saphenous vein taken from a patients leg is used for coronary artery bypass grafting, even though a significant percentage of vein grafts eventually fail. Arterial grafts are the preferred conduits because they are less prone to becoming obstructed.

However, they are in very limited supply, as many patients require multiple grafts, which is why the researchers have been looking for the ideal small-caliber arterial substitute for re-vascularization procedures.

Led by Dr. David A. Vorp, Associate Professor of Surgery and Bioengineering, the researchers developed vascular graft by bulk seeding MDSCs inside a biodegradable porous, tubular polyester urethane scaffold using a rotational vacuum seeding device.

After they had cultured their vascular constructs for seven days, the researchers implanted them in the abdominal aortas of rats eight weeks before performing tests to determine how well the grafts had performed.

It was found that the cell-seeded constructs showed a significantly higher blockage-free rate than unseeded controls. The researchers also found that there was an extensive remodelling of the MDSC-seeded polymer by surrounding tissue, exhibiting tissue formation that is consistent with a mature artery.

Dr. Vorp says that the new findings demonstrate the feasibility of developing MDSC-seeded tissue-engineered vascular grafts for eventual human application.

The next step is to demonstrate the use of the tissue-engineered blood vessel in a larger animal model, such as a pig, which has a coa gulation system more similar to that in humans. The advantage of our approach is that the graft could utilize the patients own stem cells and be ready for implantation almost immediately or, at most, after a relatively short culture period. This suggests that we could make these available off-the-shelf, which is an essential element for clinical translation, he explained.


Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:

(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... ... ... Comfort Keepers® of San Diego, CA is excited to announce they are ... drive cancer patients to and from their cancer treatments. Comfort Keepers provides quality ... and ongoing independence. Getting to and from medical treatments is one of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its first-ever ... Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding work ... Practice and Pediatric Emergency Medicine Practice. , “With this award, we recognize ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, ... Global Forecast to 2021" report to their offering. ... pharmaceutical excipients market is projected to reach USD 8.1 ... the forecast period 2016 to 2021. ...
Breaking Medicine Technology: