Navigation Links
Scientists Develop Artificial Blood Vessels for Vascular Grafts in Mice

Researchers at the University of Pittsburgh School of Medicine have developed artificial blood vessels, which may have significant implications for the treatment of heart and kidney disorders .

The vessels, made from muscle-derived stem cells (MDSCs) and a biodegradable polymer, exhibit extensive remodelling, and remain free of blockages when grafted into rats.

The saphenous vein taken from a patients leg is used for coronary artery bypass grafting, even though a significant percentage of vein grafts eventually fail. Arterial grafts are the preferred conduits because they are less prone to becoming obstructed.

However, they are in very limited supply, as many patients require multiple grafts, which is why the researchers have been looking for the ideal small-caliber arterial substitute for re-vascularization procedures.

Led by Dr. David A. Vorp, Associate Professor of Surgery and Bioengineering, the researchers developed vascular graft by bulk seeding MDSCs inside a biodegradable porous, tubular polyester urethane scaffold using a rotational vacuum seeding device.

After they had cultured their vascular constructs for seven days, the researchers implanted them in the abdominal aortas of rats eight weeks before performing tests to determine how well the grafts had performed.

It was found that the cell-seeded constructs showed a significantly higher blockage-free rate than unseeded controls. The researchers also found that there was an extensive remodelling of the MDSC-seeded polymer by surrounding tissue, exhibiting tissue formation that is consistent with a mature artery.

Dr. Vorp says that the new findings demonstrate the feasibility of developing MDSC-seeded tissue-engineered vascular grafts for eventual human application.

The next step is to demonstrate the use of the tissue-engineered blood vessel in a larger animal model, such as a pig, which has a coa gulation system more similar to that in humans. The advantage of our approach is that the graft could utilize the patients own stem cells and be ready for implantation almost immediately or, at most, after a relatively short culture period. This suggests that we could make these available off-the-shelf, which is an essential element for clinical translation, he explained.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... , ... June 27, 2016 , ... ... mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... to the network of the Tennessee Counseling Association, adding exclusive benefits and promotional ...
(Date:6/26/2016)... ... ... Quality metrics are proliferating in cancer care, and are derived from many ... the beholder, according to experts who offered insights and commentary in the current issue ... the full issue, click here . , For the American Society of Clinical ...
(Date:6/26/2016)... ... 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop ... The fitness app plans to fix the two major problems leading the fitness industry today:, ... all type program , They don’t eliminate all the reasons people quit their ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
Breaking Medicine Technology: