Navigation Links
Scientists Develop Artificial Blood Vessels for Vascular Grafts in Mice

Researchers at the University of Pittsburgh School of Medicine have developed artificial blood vessels, which may have significant implications for the treatment of heart and kidney disorders .

The vessels, made from muscle-derived stem cells (MDSCs) and a biodegradable polymer, exhibit extensive remodelling, and remain free of blockages when grafted into rats.

The saphenous vein taken from a patients leg is used for coronary artery bypass grafting, even though a significant percentage of vein grafts eventually fail. Arterial grafts are the preferred conduits because they are less prone to becoming obstructed.

However, they are in very limited supply, as many patients require multiple grafts, which is why the researchers have been looking for the ideal small-caliber arterial substitute for re-vascularization procedures.

Led by Dr. David A. Vorp, Associate Professor of Surgery and Bioengineering, the researchers developed vascular graft by bulk seeding MDSCs inside a biodegradable porous, tubular polyester urethane scaffold using a rotational vacuum seeding device.

After they had cultured their vascular constructs for seven days, the researchers implanted them in the abdominal aortas of rats eight weeks before performing tests to determine how well the grafts had performed.

It was found that the cell-seeded constructs showed a significantly higher blockage-free rate than unseeded controls. The researchers also found that there was an extensive remodelling of the MDSC-seeded polymer by surrounding tissue, exhibiting tissue formation that is consistent with a mature artery.

Dr. Vorp says that the new findings demonstrate the feasibility of developing MDSC-seeded tissue-engineered vascular grafts for eventual human application.

The next step is to demonstrate the use of the tissue-engineered blood vessel in a larger animal model, such as a pig, which has a coa
'"/>




Page: 1 2

Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
(Date:3/4/2015)... Austria (PRWEB) March 04, 2015 ... reduce subjectivity in density assessment and help improve ... of numerous abstracts accepted for presentation at the ... 2015. Ten abstracts - eight posters and ... Volpara Solutions’ automated breast density and quantitative breast ...
(Date:3/4/2015)... 2015 More than a year after ... associated with low testosterone treatments ( http://www.testosteronelawsuithub.com/ ), the ... will now require manufacturers to warn patients that this ... attacks and strokes. In a Drug Safety Communication ... that it was requiring testosterone manufacturers to update the ...
(Date:3/4/2015)... The print component of “Organic Living” ... Chronicle with a circulation of approximately 173,000 copies and ... is distributed nationally through a vast social media strategy ... partner outlets. To explore the digital version of the ... composed of heat-dried microbes that have digested the organic ...
(Date:3/4/2015)... The Global Liquefied Petroleum Gas ... and is estimated to grow to $288.7 billion ... 2014 to 2019. , Browse through the TOC ... analysis of industry trends, segments & forecasts., ... gas market is classified into source, application, and ...
(Date:3/4/2015)... Dallas, Texas (PRWEB) March 04, 2015 ... materials, equipment, downstream client survey, marketing channels, industry ... basic overview of the industry, including spices definitions, ... and Chinese domestic market analysis are provided with ... landscape of the market. A comparison between the ...
Breaking Medicine News(10 mins):Health News:Research Finds Use of Volpara Solutions’ Quantitative Breast Imaging Tools Help Reduce Subjectivity in Density Assessment and Improve Breast Cancer Risk Prediction 2Health News:Research Finds Use of Volpara Solutions’ Quantitative Breast Imaging Tools Help Reduce Subjectivity in Density Assessment and Improve Breast Cancer Risk Prediction 3Health News:Research Finds Use of Volpara Solutions’ Quantitative Breast Imaging Tools Help Reduce Subjectivity in Density Assessment and Improve Breast Cancer Risk Prediction 4Health News:Research Finds Use of Volpara Solutions’ Quantitative Breast Imaging Tools Help Reduce Subjectivity in Density Assessment and Improve Breast Cancer Risk Prediction 5Health News:Testosterone Lawsuit Attorneys at Bernstein Liebhard LLP Comment on FDA Mandate For New Cardiovascular Warnings on Low T Therapy Drugs 2Health News:Testosterone Lawsuit Attorneys at Bernstein Liebhard LLP Comment on FDA Mandate For New Cardiovascular Warnings on Low T Therapy Drugs 3Health News:Testosterone Lawsuit Attorneys at Bernstein Liebhard LLP Comment on FDA Mandate For New Cardiovascular Warnings on Low T Therapy Drugs 4Health News:The Global Liquefied Petroleum Gas Market is Estimated to Reach $288.7 Billion by 2019 - A Report by MicroMarket Monitor 2Health News:The Global Liquefied Petroleum Gas Market is Estimated to Reach $288.7 Billion by 2019 - A Report by MicroMarket Monitor 3Health News:World Spices Market Overview & Development 2015-2020 Now Available at DeepResearchReports.com 2Health News:World Spices Market Overview & Development 2015-2020 Now Available at DeepResearchReports.com 3
... a special issue of the online journal Sexuality ... California Press reveal that abstinence-only-until-marriage sex education programs fail ... about condoms, and violate human rights principles. Edited by ... the Heilbrunn Department of Family and Population Health and ...
... Association of Marriage and Family Therapy (AAMFT), anger is one of the ... their problem, but feel hopeless to change. There is hope and help ... ... 2008 -- Personal Power Path announces the launch of a new online ...
... their younger counterparts, older problem gamblers who ask casinos to ... likely to do so because they fear they will kill ... study. , Researchers Lia Nower, JD, PhD, of the ... of the University of Sydney, Australia, looked at 1,601 self-described ...
... AMDL, Inc. (Amex:,ADL), a vertically integrated pharmaceutical company ... it is reaffirming guidance for Q3 and,FY2008. Additionally, the ... response to the heightened activity in its common stock,on ... While it is the Company,s normal policy to not ...
... Scientists and clinicians from around the world ... the American Association for Cancer Research,s third International ... , The conference is subtitled, "Fulfilling the Promise ... molecular diagnostics to provide new strategies for tailoring ...
... feeding units are responding,to the devastation brought by Hurricane ... are currently in the disaster zone serving the,millions of ... Beaumont,Galveston, Houston and Lufkin., "Our ,strike team, members ... the,extent of the devastation," said Major Marshall Gesner, Greater ...
Cached Medicine News:Health News:Accuracy, efficacy and ethics of abstinence-only programs questioned by public health experts 2Health News:Accuracy, efficacy and ethics of abstinence-only programs questioned by public health experts 3Health News:Accuracy, efficacy and ethics of abstinence-only programs questioned by public health experts 4Health News:Older problem gamblers may face greater suicide risk than younger counterparts, study finds 2Health News:AMDL Reaffirms 2008 Guidance and Provides Additional Information 2Health News:AMDL Reaffirms 2008 Guidance and Provides Additional Information 3Health News:Scientists take cancer research back to the basic molecular level 2Health News:MultiVu Video Feed: Salvation Army Responding to Hurricane Ike With Food, Water & Pastoral Care 2
(Date:3/4/2015)... -- Mail-service and specialty pharmacies will save ... plans $11.8 billion over the next decade, according ... Association (PCMA). "Home delivery of traditional ... ways to reduce health costs," said PCMA President ... resist efforts to restrict these cost-saving tools." ...
(Date:3/4/2015)... BRISTOL, Tenn. , March 4, 2015 ... has reached an agreement with Sprout Pharmaceuticals to manufacture ... intending for Flibanserin to be the first drug approved ... common form of female sexual dysfunction. The ... facility in Bristol, Tennessee . ...
(Date:3/4/2015)... , March 4, 2015   Aratana Therapeutics, ... therapeutics company focused on the licensing, development and commercialization ... that it will present at the Barclays Global ... at the Loews Miami Beach Hotel in ... St. Peter , M.D., President and Chief Executive Officer ...
Breaking Medicine Technology:PCMA: Report Shows High-Tech Specialty and Mail-Service Pharmacies Will Reduce Costs for Illinois Employers, Consumers and Public Programs by $11.8 Billion 2UPM Pharmaceuticals to Manufacture Sprout Pharmaceuticals' Flibanserin Tablets 2UPM Pharmaceuticals to Manufacture Sprout Pharmaceuticals' Flibanserin Tablets 3Aratana Therapeutics to Present at the Barclays Global Healthcare Conference 2
... protein is a 185 kD trans-membrane glycoprotein ... cases of breast cancer show an amplification ... Since the introduction of Herceptin® as a ... testing of Her-2/neu in breast carcinoma has ...
... of 3 can choose either the PARI LC ... principle applies to both:, ,Maximize aerosol output ... when the patient exhales using two one-way valves. ... the nebulizer. The result is a high percentage ...
... practitioners consider the HOPE nebulizer the gold standard ... made to put everything together in one convenient ... is our #11330 Pediatric HOPE Kit which contains ... and pediatric aerosol mask all in one set ...
... of medication as well as humidification, try ... dilution, high volume, continuous medication nebulizer (CMN), ... patients. Its 200 ml reservoir and jet ... hours of nebulized medication delivery at 25 ...
Medicine Products: