The War between scientists and bacteria has been going on for sometime now. Sometimes it appears the scientists have an upper hand when they come up with a new anti-biotic that// successfully conquers the particular strain of bacteria, and when the celebrations are still going on, different resistant strains make an appearance leaving the scientists baffled.
Now it seems that a team of scientists at the Weizmann Institute of Science have finally succeeded in designing a powerful weapon that would fight anti-resistant strains also more effectively.
The new weapon has a combination of key properties of two different types of weapons used by the innate defense systems of organisms, and is hence more effective.
The first is a "magnetic" weapon - a natural antibiotic produced by all organisms. Because these antimicrobial peptides (AMPs) are positively charged, they are attracted to the bacteria's negatively charged surface like a magnet, where they can then exert their antibacterial effects. The second, "detergent-like" weapon - called a lipopeptide - is produced only by bacteria and fungi which, due to a negative charge, target mainly fungi.
This weapon contains a fatty acid chain that, like similar chains in soap which dissolve dirt and oils, breaks down the fatty membranes of the fungi.
As reported in the Proceedings of the National Academy of Sciences (PNAS), Prof. Yechiel Shai and Ph.D. students Arik Makovitzki and Dorit Avrahami of the Biological Chemistry Department have succeeded in combining the properties of AMPs with lipopeptides - resulting in a synthetic lipopeptide that has both a positive charge and the soap-like ability to dissolve oils.
By altering the length of the fatty acid chains and the sequence of positively charged amino acids, they were able to create an array of weapons. Some are active against both bacteria and fungi, while others target just one or the other. And, asPage: 1 2 Related medicine news :1
. Scientists plan human cloning clinic in the United States2
. Scientists found ancient Human Germ Killer3
. Scientists locate key hormone involved in appetite control4
. Scientists open the book of life 5
. Scientists review SARS6
. Scientists crack dengue fever puzzle7
. Scientists push to lower hidden sodium in food8
. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome9
. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
. Scientists reveal the secrets of sarcasm
. Scientists Unveil Mechanism Behind Resistance to Severe Malaria