Navigation Links
Scientists Activate New Cancer Drug Using Light and Oxygen

Researchers at the Ontario Cancer Institute at Princess Margaret Hospital have successfully proven that cancer cells alone can be killed by a new cancer drug that is triggered by a laser light, a process known as photodynamic therapy (PDT).

In a study published today in the Proceedings of the National Academy of Sciences (PNAS), Dr. Gang Zheng, Senior Scientist - Division of Biophysics and Bioimaging, Joey and Toby Tanenbaum/Brazilian Ball Chair for Prostate Cancer Research - Ontario Cancer Institute, Associate Professor, Medical Biophysics - University of Toronto, and Dr. Brian Wilson, Head - Division of Biophysics and Imaging - Ontario Cancer Institute, Professor - Department of Medical Biophysics - University of Toronto, describe the PDT process that they have collaborated on over three years. The collaboration began before Dr. Zheng was recruited to OCI from the University of Pennsylvania in August 2006.

Their paper describes how these new photosensitizer drugs can only be activated by light once they have been localized in the target tumor cells. For the first time Zheng and Wilson have demonstrated that tumor cells can be selectively attacked using a PDT. When the light activates this new drug, it then works to produce a reactive form of oxygen, which destroys only the cells that have been marked by the cancer-fighting drug, thereby sparing other normal healthy neighboring cells.

The process really is about controlling the drugs ability to produce this reactive form of oxygen, explains Dr. Zheng. For the first time, using mouse models and on separate cells, we have shown that it is possible to limit the collateral damage to surrounding normal cells using this approach.

Clinical trials in patients are still a year or two away.

This is an exciting step in the fight against cancer, said Dr. Wilson. This process should greatly enhance the therapeutic window, making tumors much more suscepti ble for PDT damage than normal cells and tissues.

This study is a follow-up to Dr. Zhengs and Dr. Wilsons 2004 concept paper, published in the Journal of the American Chemical Society, that describes the theory of what they have now proven in the lab.

The Ontario Cancer Institute at Princess Margaret Hospital is one of the world leaders in terms of PDT delivery, said Dr. Christopher Paige, Vice President, Research and Senior Scientist Division of Stem Cell and Developmental Biology, Ontario Cancer Institute. The cooperation between Dr. Zheng and Dr. Wilson, even before Dr. Zheng joined us at OCI, demonstrates the incredible spirit of collaboration that we pride ourselves on at University Health Network.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... ... May 26, 2017 , ... ... CareFusion NOX-T3 portable sleep monitor with its Somnoware Sleep Device Interface (SDI). Somnoware ... for diagnostic device operations. With this platform, initializing devices and importing studies are ...
(Date:5/26/2017)... Sparks, Nevada (PRWEB) , ... May 26, 2017 ... ... to produce the first ever copper, antimicrobial, mesh back 24/7 task chair specifically ... and conference applications. “We are thrilled to partner with Cupron® to provide ...
(Date:5/26/2017)... Texas (PRWEB) , ... May 26, 2017 , ... Yisrayl ... a new publication this week that is focusing on the Peace Agreements being discussed ... his Middle East sprint in a race to try to speed up peace talks ...
(Date:5/26/2017)... Francisco, CA (PRWEB) , ... May 26, 2017 , ... ... Francisco, is proud to announce a new, informational blog post on insurance options. If ... surgery, checking insurance plans may help save time and money. Visiting an in-network provider ...
(Date:5/26/2017)... ... 26, 2017 , ... Centennial-based BluSky Restoration Contractors announced that ... Annual Clays for Kids fundraiser, to be held Friday, Sept. 22, at Kiowa ... part of BluSky’s partnership with The Adoption Exchange, BluSky will also share sponsorship ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)...  Two Bayer U.S. Pharmaceutical leaders received top awards ... 28 th Woman of the Year ... longstanding mission of furthering the advancement and impact of ... Cindy Powell-Steffen , senior director of brand activation and ... Libby Howe , a regional business manager for New ...
(Date:5/15/2017)... Inc., a privately-held CNS pharmaceutical company based in ... disease (PD), has enrolled the first patient in the RASMET ... study involving patients with PD and taking place at 12 ... period. The first stage is open label and involves single ... Denver , Boca Raton ...
(Date:5/10/2017)... Inc. (Nasdaq: HOLX ) announced today the ... April 1, 2017 .   GAAP diluted earnings per ... prior year period as the sale of the blood ... diluted EPS of $0.50 increased 6.4%.  Revenue of $715.4 ... Excluding the effects of blood screening and the acquired ...
Breaking Medicine Technology: