Navigation Links
Scientists Activate New Cancer Drug Using Light and Oxygen

Researchers at the Ontario Cancer Institute at Princess Margaret Hospital have successfully proven that cancer cells alone can be killed by a new cancer drug that is triggered by a laser light, a process known as photodynamic therapy (PDT).

In a study published today in the Proceedings of the National Academy of Sciences (PNAS), Dr. Gang Zheng, Senior Scientist - Division of Biophysics and Bioimaging, Joey and Toby Tanenbaum/Brazilian Ball Chair for Prostate Cancer Research - Ontario Cancer Institute, Associate Professor, Medical Biophysics - University of Toronto, and Dr. Brian Wilson, Head - Division of Biophysics and Imaging - Ontario Cancer Institute, Professor - Department of Medical Biophysics - University of Toronto, describe the PDT process that they have collaborated on over three years. The collaboration began before Dr. Zheng was recruited to OCI from the University of Pennsylvania in August 2006.

Their paper describes how these new photosensitizer drugs can only be activated by light once they have been localized in the target tumor cells. For the first time Zheng and Wilson have demonstrated that tumor cells can be selectively attacked using a PDT. When the light activates this new drug, it then works to produce a reactive form of oxygen, which destroys only the cells that have been marked by the cancer-fighting drug, thereby sparing other normal healthy neighboring cells.

The process really is about controlling the drugs ability to produce this reactive form of oxygen, explains Dr. Zheng. For the first time, using mouse models and on separate cells, we have shown that it is possible to limit the collateral damage to surrounding normal cells using this approach.

Clinical trials in patients are still a year or two away.

This is an exciting step in the fight against cancer, said Dr. Wilson. This process should greatly enhance the therapeutic window, making tumors much more suscepti ble for PDT damage than normal cells and tissues.

This study is a follow-up to Dr. Zhengs and Dr. Wilsons 2004 concept paper, published in the Journal of the American Chemical Society, that describes the theory of what they have now proven in the lab.

The Ontario Cancer Institute at Princess Margaret Hospital is one of the world leaders in terms of PDT delivery, said Dr. Christopher Paige, Vice President, Research and Senior Scientist Division of Stem Cell and Developmental Biology, Ontario Cancer Institute. The cooperation between Dr. Zheng and Dr. Wilson, even before Dr. Zheng joined us at OCI, demonstrates the incredible spirit of collaboration that we pride ourselves on at University Health Network.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... January 20, 2017 , ... Vitamin Well has launched two ... drinks have been produced in collaboration with Zlatan Ibrahimovic and have been developed ... After a successful launch in Sweden last year, the next generation sports drinks ...
(Date:1/20/2017)... ... ... Angel”: a heartwarming and earnest tale of faith and believing in the path ... the creation of published author, Marjorie Lund-Fontaine, a former professional violinist, alumnus of The ... of her new book, Marjorie says, “‘The Angel’ was written as a fairytale, but ...
(Date:1/20/2017)... ... 2017 , ... “I Forgive You”: a fine examination of how God handles sin, including ... of published author, Stephen Miller, who, for over ten long years has been waiting to ... in Trinidad and Tobago, he has been serving the Lord for over twenty years, and ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... “Christmas in ... creation of published author, Sara Seymour, who lives in Lafayette, Indiana where she works ... sips on iced coffees and writes. , Published by Christian Faith Publishing, Sara Seymour’s ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Knowledge is God’s Lighthouse”: a moving and ... God’s Lighthouse” is the creation of published author, Gene Gaapf, a retired truck driver, ... , “I have been writing since high school and have many different titles,” Gaapf ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... 2017 Research and Markets has announced ... Opportunities, and Future" report to their offering. ... This research service on the ... technologies, and provides a snapshot of the key participants in the ... are provided from 2016 to 2020. The market is expected to ...
(Date:1/20/2017)... -- Avillion LLP, a co-developer and financier of late-stage ... MD MBA as Chief Medical Officer. Dr Weinberg will be based ... ... spent more than 17 years as a pharmaceutical and biotech executive ... Over the course of his career, he has interfaced with the ...
(Date:1/19/2017)... , Jan. 19, 2017 The Global Therapy ... and access to partnering deals and agreements entered into ... in partnering deals - Top deals by value - ... development, technology type The report provides understanding and ... by the world,s leading healthcare companies. The report ...
Breaking Medicine Technology: