Navigation Links
Scientist Found New Mechanism for Brain Learning

The researchers genetically engineered mice to lack an enzyme called Cdk5 in their brains by using the technique called conditional knockout, which made the animal more adept at learning and quicker at figuring out the changes in their environment, as compared to other normal rats.

"Its pretty rare that you make mice smarter, so there are a lot of cognitive implications," Nature magazine quoted senior study author Dr. James Bibb, Assistant Professor of Psychiatry, as saying.

"Everything is more meaningful to these mice. The increase in sensitivity to their surroundings seems to have made them smarter," he added.

The researcher said that the genetically engineered mice were found to be more adept at learning to navigate a water maze, and remembering that being in a certain box involved a mild shock. He further said that when the water maze was rearranged, the engineered mice were much faster to realize that things were different, and worked out the new route.

Normally, Cdk5 works with another enzyme to break up a molecule called NR2B, which has previously been implicated in the early stages of learning.

The new research showed that when Cdk5 is removed from the brain, the levels of NR2B significantly increase, and the mice are primed to learn, said Dr. Bibb.

"Being able to turn a gene off throughout a brain is a really advanced thing to do. Its been shown that it can be done, but we put the system together and actually applied it," he said.

Since Cdk5 is heavily implicated in Alzheimers disease and addiction to drugs of abuse, Dr. Bibb believes that the understanding of how the enzyme affects the brain and behavior may aid in the development of new treatments for these conditions and post-traumatic stress disorder.

"We made the animals smarter, but in doing so and applying this technology, we also found biochemical targets that hold promise for future trea tments of a variety of cognitive disorders," Dr. Bibb said.

He, however, admitted that the long-term effects of deleting the Cdk5 enzyme are yet to be determined. He also said that studies were going on to develop drugs that would help create the same effects without genetic manipulation.

The study also showed nerve-cell firings in the hippocampus, an area of the brain associated with learning. Hippocampus slices from the knock-out mice responded much more strongly to an electrical stimulation, supporting the finding that the mice were more prepared to learn.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... Head Island, SC (PRWEB) , ... February 08, 2016 , ... ... and surrounding areas with a vital new community enrichment program, has teamed up with ... local women and children suffering from intimate abuse. To support all those victimized by ...
(Date:2/8/2016)... ... 2016 , ... Delta Dental of California and its affiliated companies announced today ... Radine, who recently retired as president and CEO of Delta Dental of California and ... the Year , helped lead the effort to raise funds for studies to strengthen ...
(Date:2/8/2016)... ... February 08, 2016 , ... Eating disorders and ... number of women and men with eating disorders report a history of trauma, ... the development of an eating disorder. , At the 2016 iaedp Symposium, ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... lower incidence rate of type 2 diabetes in the GrassrootsHealth cohort with substantially ... to make a change in public health,” states Carole Baggerly, Director of GrassrootsHealth, ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... will be speaking on how healthcare companies can use newly released government data ... health of a population and intervene and capture the value they create to ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... France , Germany , ... Israel ). It includes a 10-year epidemiology forecast for the total ... and sex in these markets. GD epidemiology report is written and developed ... transparent and market-driven, providing expert analysis of disease trends in the 7MM. ... Italy , Spain , UK, and ...
(Date:2/4/2016)... Ohio , Feb. 4, 2016 For ... Program, or those already participating in the program, the ... often referred to as the , Mega-Guidance , could ... final guidance is published in September 2016. ... Product and Service Marketing , summarizes the Mega-Guidance,s key ...
(Date:2/4/2016)... -- The Senior Care Pharmacy Coalition (SCPC) today commended ... Jason Chaffetz (R-UT) and Ranking Member Elijah ... "Developments in the Prescription Drug Market," to examine ... abusive pharmacy benefit manager (PBM) pricing practices. ... Elijah Cummings (D-MD) are diligent, serious lawmakers committed ...
Breaking Medicine Technology: