Navigation Links
Scientist Found New Mechanism for Brain Learning

The researchers genetically engineered mice to lack an enzyme called Cdk5 in their brains by using the technique called conditional knockout, which made the animal more adept at learning and quicker at figuring out the changes in their environment, as compared to other normal rats.

"Its pretty rare that you make mice smarter, so there are a lot of cognitive implications," Nature magazine quoted senior study author Dr. James Bibb, Assistant Professor of Psychiatry, as saying.

"Everything is more meaningful to these mice. The increase in sensitivity to their surroundings seems to have made them smarter," he added.

The researcher said that the genetically engineered mice were found to be more adept at learning to navigate a water maze, and remembering that being in a certain box involved a mild shock. He further said that when the water maze was rearranged, the engineered mice were much faster to realize that things were different, and worked out the new route.

Normally, Cdk5 works with another enzyme to break up a molecule called NR2B, which has previously been implicated in the early stages of learning.

The new research showed that when Cdk5 is removed from the brain, the levels of NR2B significantly increase, and the mice are primed to learn, said Dr. Bibb.

"Being able to turn a gene off throughout a brain is a really advanced thing to do. Its been shown that it can be done, but we put the system together and actually applied it," he said.

Since Cdk5 is heavily implicated in Alzheimers disease and addiction to drugs of abuse, Dr. Bibb believes that the understanding of how the enzyme affects the brain and behavior may aid in the development of new treatments for these conditions and post-traumatic stress disorder.

"We made the animals smarter, but in doing so and applying this technology, we also found biochemical targets that hold promise for future trea tments of a variety of cognitive disorders," Dr. Bibb said.

He, however, admitted that the long-term effects of deleting the Cdk5 enzyme are yet to be determined. He also said that studies were going on to develop drugs that would help create the same effects without genetic manipulation.

The study also showed nerve-cell firings in the hippocampus, an area of the brain associated with learning. Hippocampus slices from the knock-out mice responded much more strongly to an electrical stimulation, supporting the finding that the mice were more prepared to learn.


'"/>




Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... AL (PRWEB) , ... December 02, 2016 , ... ... from across the Dothan-Wiregrass Area in Alabama are expected to attend the UNCF ... Schmitz, will help provide scholarship funds for area students and operating support to ...
(Date:12/2/2016)... ... 02, 2016 , ... The annual time frame to change Medicare health and ... ending December 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their current ... need to make changes during this period order for their new policy to go ...
(Date:12/2/2016)... CA (PRWEB) , ... December 02, 2016 , ... ... surgeon in Beverly Hills, California, will be included in the 2016 “Guide to ... to exceptional professionals based on the amalgamation of their education, experience, and professional ...
(Date:12/2/2016)... ... 02, 2016 , ... The PAINWeekEnd Regional Conference will be ... in Honolulu, offering local frontline clinicians the opportunity to extend their certified continuing ... for supplemental training related to pain management has surged dramatically in recent years, ...
(Date:12/2/2016)... , ... December 02, 2016 , ... Yisrayl Hawkins, at ... into how this current generation fits into Bible Prophecy. Yisrayl says this generation, known ... pointing to this conclusion, showing how the details line up exactly with Bible Prophecy ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... On Thursday, the NASDAQ Composite ended the trading ... edged 0.36% higher, to finish at 19,191.93; and the S&P ... as six out of nine sectors ended the day in ... Services equities: Myriad Genetics Inc. (NASDAQ: MYGN ), ... Inc. (NASDAQ: INCR ), and La Quinta Holdings ...
(Date:12/2/2016)... 1, 2016 The concept of rare diseases and ... to this sector has been taking shape in ... political aspects and initiatives related to orphan medicinal products have ... level of member states individually. Many member states in the ... space of orphan medicinal products, the result of which took ...
(Date:12/2/2016)... 2016 Around the corners of world, cancer ... habitable land present over earth. Cancer has become one ... a life time this is because of the increasing ... Given the steady increase in global cancer incidence with ... healthcare costs of treatment, there is increasing interest in ...
Breaking Medicine Technology: