Navigation Links
Salmonella Bacteria Are Deceptive

Salmonella bacteria are known as the agent involved in food poisoning and account for hundreds of thousands of deaths worldwide. // However this bacterium invades by stealth and hides from macrophages before entering them and multiplying inside them. This is ironical since macrophages are the cells meant to detect such bacteria.

Just how Salmonella escapes detection by macrophages, turning predator cells to prey complicit in promoting infection, has seemed impossibly complicated, a needle-in-a-haystack proposition involving thousands of proteins, the building blocks that carry out cells' vital functions.

Applying the high-volume sorting and analytical power of proteomics--a detailed survey of microbial proteins present in the 24 hours that follow mouse-macrophage infection--a team led by Liang Shi of the Department of Energy's Pacific Northwest National Laboratory has turned up a suspect protein.

The discovery of the protein, dubbed STM3117, is detailed today (Sept. 29) in The Journal of Biological Chemistry. Knocking out the gene that codes for STM3117, the researchers subsequently crippled the microbe's ability to multiply inside macrophages. Shi and colleagues say the protein and two closely related proteins discovered in the study are similar in genetic sequence to those known to make and modify chemicals in the microbe's cell wall called peptidoglycan.

Drug and vaccine designers armed with this mouse-model information can target chemicals or immune responses that disrupt peptidoglycan synthesis and other processes linked to Salmonella's colonization of macrophages in humans, said Joshua Adkins, a co-author on Shi's paper and lead author of a related study in Molecular & Cellular Proteomics last month. A quick identification of these proteins, Adkins added, could help physicians assess the virulence of a given strain.

The candidate proteins were winnowed from among 315 possibilities that emerged through
'"/>




Page: 1 2

Related medicine news :

1. Public Requested To Discard Cheese Products Contaminated With Salmonella
2. Salmonella Poisoned Frozen Pasta Hit Six
3. Salmonella Affected Cases Rises to 31
4. Cadbury Blamed for Salmonella Outbreak
5. Salmonella Outbreak under Investigation
6. Tomatoes: Culprits of Salmonella outbreak
7. Salmonella enteritidis In Chicken Meat Causes Sickness
8. Salmonella Contamination Suspected In A Brand Of Fresh Spinach
9. Health Officials Suspect Salmonella In Peanut Butter
10. Consumers Warned of Using Cat Food Due to Salmonella Contamination
11. Salmonella Poisoning Suspected In Peanut Butter
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Salmonella Bacteria Are Deceptive

(Date:7/31/2014)... CAMBRIDGE, Mass. (July 31, 2014) Long associated ... ancient cellular survival response regulated by Heat-Shock Factor ... their environment into co-conspirators that support malignant progression ... Institute scientists this week in the journal ... with significant implications for the diagnosis, prognosis, and ...
(Date:7/31/2014)... New York (PRWEB) July 31, 2014 ... Market Research, "Orthopedic Trauma Fixation Devices Market - Global ... - 2020," the global orthopedic trauma fixation devices market ... is expected to grow at a CAGR of 7.2% ... of USD 9.3 billion in 2020. Globally, the orthopedic ...
(Date:7/31/2014)... This news release is available in German ... The insular cortex is an integral "hub", combining ... in insular structure and function have been reported ... depression, addiction and autism spectrum disorders (ASD). Scientists ... Neurobiology in Martinsried now describe consistent alterations in ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 The ... the colorants market in North America with analysis ... the TOC of the North American Colorants Market ... analysis provided. This also provides a glimpse of ... and is supported by various tables and figures. ...
(Date:7/31/2014)... virus that causes cold sores -- herpes simplex type 1 ... to a new study. Researchers in Australia found ... with the virus. This explains why some people with the ... only occasionally. The authors said the findings could lead to ... the disease was dormant, it was a truce. It turns ...
Breaking Medicine News(10 mins):Health News:Master HSF supports reprogramming of normal cells to enable tumor growth and metastasi 2Health News:Master HSF supports reprogramming of normal cells to enable tumor growth and metastasi 3Health News:Orthopedic Trauma Fixation Devices Market: Global Forecast, Share, Size, Growth and Industry Analysis 2014 - 2020 2Health News:Orthopedic Trauma Fixation Devices Market: Global Forecast, Share, Size, Growth and Industry Analysis 2014 - 2020 3Health News:Insular cortex alterations in mouse models of autism 2Health News:Insular cortex alterations in mouse models of autism 3Health News:Americas Colorants Market is Expected to Reach 2,006 Thousand MT in 2018 - New Report by MicroMarket Monitor 2Health News:Americas Colorants Market is Expected to Reach 2,006 Thousand MT in 2018 - New Report by MicroMarket Monitor 3Health News:Americas Colorants Market is Expected to Reach 2,006 Thousand MT in 2018 - New Report by MicroMarket Monitor 4Health News:Cold Sore Virus Active Without Symptoms, Study Finds 2
... abnormal brain activity, researchers say , THURSDAY, Feb. 18 ... illness known as generalized anxiety disorder, a new study ... ways. , The study authors say the research ... suffering from debilitating anxiety. , "Patients experience anxiety ...
... ... Centers for Knee and Hip Replacement are part of the Blue Cross and Blue Shield ... ... has designated Abington Memorial Hospital as a Blue Distinction Center for Spine Surgery ...
... ... his new Authentic/Biblica book, Talking Smack , ... (PRWEB) February 18, 2010 -- Are you talking smack? You’d better be., , ... who has worked with parents and teens for more than 20 years and created the ...
... ... to begin an online journey, find the right ways to embrace this new communication environment ... ... of change for communicators everywhere. After a devastating recession in 2009, this year has ...
... ... delivery errors while protecting patients and caregivers. , ... Ferndale, MI (PRWEB) Feb. 18, 2010 ... of the Enovate Medication Cart, the newest addition to its medical cart series. ...
... ... (PCBs) and PCB engineering and design services, announces the availability of specialized PCBs for ... develop medical electronic printed circuit assemblies. , ... Chicago, IL (PRWEB) February 18, 2010 -- Electronic ...
Cached Medicine News:Health News:Anxiety Disorder Patients Process Emotions Differently 2Health News:Abington Memorial Hospital Earns Two Designations: Blue Distinction Center for Spine Surgery(SM) and Blue Distinction Center for Knee and Hip Replacement(SM) 2Health News:Abington Memorial Hospital Earns Two Designations: Blue Distinction Center for Spine Surgery(SM) and Blue Distinction Center for Knee and Hip Replacement(SM) 3Health News:Abington Memorial Hospital Earns Two Designations: Blue Distinction Center for Spine Surgery(SM) and Blue Distinction Center for Knee and Hip Replacement(SM) 4Health News:Talking Smack to Keep Kids Drug-Free 2Health News:Talking Smack to Keep Kids Drug-Free 3Health News:Your e-Marketing Journey in 2010: An e-Book for Corporate Communicators Working in European Headquarters 2Health News:Enovate Announces New Lightweight Medication Cart Series 2Health News:Enovate Announces New Lightweight Medication Cart Series 3Health News:Electronic Interconnect Offers Medical Electronics, PCBs, Design Engineering 2Health News:Electronic Interconnect Offers Medical Electronics, PCBs, Design Engineering 3
(Date:7/31/2014)... Deutschland, 31. Juli 2014  invendo medical ... („robotischen") Koloskopie-Systems für den Einmalgebrauch, verkündete heute, ... weltweit anerkannter Manager im Bereich Medizintechnik, als ... stößt. Logo - ... hochangesehener globaler Visionär der Medizintechnikbranche. Er war ...
(Date:7/31/2014)... , July 31, 2014  Celsion Corporation (NASDAQ: ... host a conference call to discuss its second quarter ... August 7, 2014. To participate in the call, interested ... ) or 1-785-830-1924 (International/Toll) and ask for the Celsion ... to register ten minutes before the call is scheduled ...
(Date:7/31/2014)... 2014 Endo International plc (NASDAQ: ... revenues of $719 million, an increase of 1 percent ... Endo reported net income of $21 million in the ... million in the second quarter of 2013.  As detailed ... for the three months ended June 30, 2014 increased by ...
Breaking Medicine Technology:invendo medical holt Nachum (Homi) Shamir in den Board of Directors des Unternehmens 2invendo medical holt Nachum (Homi) Shamir in den Board of Directors des Unternehmens 3Celsion Corporation to Hold Second Quarter 2014 Financial Results 2Endo Reports Second Quarter Financial Results 2Endo Reports Second Quarter Financial Results 3Endo Reports Second Quarter Financial Results 4Endo Reports Second Quarter Financial Results 5Endo Reports Second Quarter Financial Results 6Endo Reports Second Quarter Financial Results 7Endo Reports Second Quarter Financial Results 8Endo Reports Second Quarter Financial Results 9Endo Reports Second Quarter Financial Results 10Endo Reports Second Quarter Financial Results 11Endo Reports Second Quarter Financial Results 12Endo Reports Second Quarter Financial Results 13Endo Reports Second Quarter Financial Results 14Endo Reports Second Quarter Financial Results 15Endo Reports Second Quarter Financial Results 16Endo Reports Second Quarter Financial Results 17Endo Reports Second Quarter Financial Results 18Endo Reports Second Quarter Financial Results 19Endo Reports Second Quarter Financial Results 20Endo Reports Second Quarter Financial Results 21Endo Reports Second Quarter Financial Results 22Endo Reports Second Quarter Financial Results 23Endo Reports Second Quarter Financial Results 24Endo Reports Second Quarter Financial Results 25Endo Reports Second Quarter Financial Results 26Endo Reports Second Quarter Financial Results 27Endo Reports Second Quarter Financial Results 28Endo Reports Second Quarter Financial Results 29Endo Reports Second Quarter Financial Results 30Endo Reports Second Quarter Financial Results 31Endo Reports Second Quarter Financial Results 32
... 2011 Reportlinker.com announces that a new ... catalogue: The Changing Role ... http://www.reportlinker.com/p0574968/The-Changing-Role-of-Natural-Products-in-Drug-Discovery.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Discovery_and_Development ... reveals how natural products have been of ...
... LOS ANGELES, July 18, 2011 The transformative power of ... were first introduced in the market. When cosmetic laser treatments ... of skin off the face to reveal smoother, younger skin ... that they could only work from the top of the ...
Cached Medicine Technology:The Changing Role of Natural Products in Drug Discovery 2The Changing Role of Natural Products in Drug Discovery 3The Changing Role of Natural Products in Drug Discovery 4Renaissance Laser and Vein Institute Specializes in Revolutionary Laser Treatments for a Variety of Cosmetic Applications 2
Colloidal Gold Conjugated, Goat anti-mouse IgG (H&L) - 12 OD...
Colloidal Gold Conjugated, Goat anti-human IgM (Mu Chain) - 12 OD...
Colloidal Gold Conjugated, Goat anti-human IgA (Alpha Chain) - 50 OD...
Polyester ribbon impregnated with conjugated Protein A - .13 OD per sq. cm....
Medicine Products: