Navigation Links
Salk Scientists - Links Between Cancer and Aging

ighly colorful variation of the FISH technique called chromosome painting. This technique 'paints' or labels every pair of the 46 chromosomes with a different colored fluorescent dye, enabling investigators to easily see breakage or fusion of chromosomes that are characteristic of damaged DNA under the microscope.

Then they artificially supplied the cultured cells with one of two genes-either a functional copy of the WRN gene, which is mutant or nonfunctional in Werner Syndrome, or a gene encoding the protein telomerase, which elongates short or missing telomeres. After cells divided several times, their DNA was reexamined for the type of damage associated with both aging and cancer.

Cells supplied with a functional WRN gene showed decreased DNA damage compared to untreated cells, which was predictable: the WRN gene encodes a protein called a helicase that unwinds tightly coiled DNA strands when cells divide. Loss of WRN protein in individuals with Werner Syndrome is responsible for the disease. Explains Crabbe, now a postdoctoral fellow at The Institute of Human Genetics in Montpellier, France, 'The lack of a single protein (WRN) induced loss of some telomeres, leading to a premature cellular growth arrest.'

However, the most interesting finding was what the scientists observed in cells supplied with added telomerase. 'When we put telomerase into cells, we suppressed accumulation of mutations to the same degree as when we put the WRN protein back,' reports Karlseder. 'It fixed the defect by elongating short telomeres seen in Werner Syndrome cells.'

Crabbe, who is continuing to study DNA replication as a postdoc, concludes that these findings not only provide a mechanism underlying accelerated aging seen in Werner Syndrome but establish a link to cancer predisposition, saying, 'These results indicate that the telomere dysfunction in Werner Syndrome cells is a major cause of genomic instability and could explain the high incid
'"/>




Page: 1 2 3

Related medicine news :

1. Scientists plan human cloning clinic in the United States
2. Scientists found ancient Human Germ Killer
3. Scientists locate key hormone involved in appetite control
4. Scientists open the book of life
5. Scientists review SARS
6. Scientists crack dengue fever puzzle
7. Scientists push to lower hidden sodium in food
8. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
9. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
10. Scientists reveal the secrets of sarcasm
11. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Salk Scientists Links Between Cancer and Aging

(Date:10/20/2014)... It’s hard to imagine what it’s like to ... around the world, it’s a reality. And while new shoes ... forced to walk barefoot on rocky terrain or sewage-lined streets ... their friends. , Buckner International's Shoes for Orphan ... in October to encourage support for Air1 and while also ...
(Date:10/20/2014)... 2014 Houston plastic surgeon Dr. ... elements of his innovative True Form Tummy Tuck® ... residents and faculty at The University of Texas ... was once a medical student. Patronella, who is a ... plastic surgery practices in Texas, The Aesthetic Center ...
(Date:10/19/2014)... Hastings and Hastings, a Phoenix personal ... throughout the greater Phoenix area and across Arizona reports ... to catastrophic automobile accidents. Statistics have indicated a steady ... Arizona. As such, Hastings and Hastings has seen a ... those who have been injured through no fault of ...
(Date:10/19/2014)... 20, 2014 Recently, BambooIndustry.com, one of ... its new range of bamboo deckings . Moreover, ... natural items; they are now available at deeply discounted ... it is hard to overstate the significance of online ... to online services. The company’s workers are striving to ...
(Date:10/19/2014)... Dallas, Texas (PRWEB) October 20, 2014 ... therapeutic development for Partial Seizure, complete with comparative ... target, mechanism of action (MoA), route of administration ... and featured news and press releases. It also ... for Partial Seizure and special features on late-stage ...
Breaking Medicine News(10 mins):Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Plastic Surgeon Patronella Presents Artistically-Inspired Tummy Tuck Method to Future Generation of Plastic Surgeons in Texas 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:High Quality Bamboo Deckings, New Items Unveiled By BambooIndustry.com 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 2Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 3Health News:Partial Seizure Therapeutic Pipeline Market Review H2 2014 in a New Report Available at RnRMarketResearch.com 4
... time could be counterproductive, researchers say , THURSDAY, Oct. 15 ... and essential part of building an immune response, and ... Tylenol -- after a shot could dampen that response, a ... that a child,s immune system is processing the immunization, providing ...
... Oct. 16 Mars Snackfood US announced today that Kyle Busch, ... Cup Series, plans to go pink this weekend during the NASCAR ... to support Susan G. Komen for the Cure®. Busch plans ... the wheel of an all pink M&M,S car during the Saturday ...
... , FORT WORTH, Texas, Oct. 16 Wound Management ... provider of specialty medical products, announced today that its subsidiary ... 24th Annual Clinical Symposium on Advances in Skin & ... opens on October 22 in San Antonio. , Dr. ...
... ... business, Dr. Philip Straka, a plastic surgeon in Houston , says he’s actually seeing ... ... be hitting a large number of economic sectors, but one area plastic surgeon says its ...
... ... of their "Tats for Tatas" fundraising campaign that will take place throughout ... company,s concerted efforts to raise awareness and funds for Breast Cancer Awareness, ... company will be donating 10% of all proceeds from sales throughout the ...
... to Feature Gena Rowlands , EAST BRUNSWICK, N.J., Oct. 15 ... return home to New Jersey to host a celebrity cocktail ... reception will raise money for National MS Society,s New Jersey ... New Jersey, where it is estimated that almost 10,000 people ...
Cached Medicine News:Health News:Tylenol May Weaken Effectiveness of Kids' Vaccines 2Health News:Mars Lends Sweet Support in Fight Against Breast Cancer Through Its M&M's(R) And Dove(R) Chocolate Brands, as Well as Its Celebrated Race Team 2Health News:Mars Lends Sweet Support in Fight Against Breast Cancer Through Its M&M's(R) And Dove(R) Chocolate Brands, as Well as Its Celebrated Race Team 3Health News:Wound Management Technologies Announces Clinical Study Presentation of CellerateRx(R) Technology at Leading Skin and Wound Care Conference 2Health News:Wound Management Technologies Announces Clinical Study Presentation of CellerateRx(R) Technology at Leading Skin and Wound Care Conference 3Health News:Houston Plastic Surgeon Seeing Growth in Aesthetic Enhancement Procedures Despite Rough Economy 2Health News:Houston Plastic Surgeon Seeing Growth in Aesthetic Enhancement Procedures Despite Rough Economy 3Health News:Atomic Tattoos Announces "Tats for Tatas" October Fundraising Event to Benefit Local Breast Cancer Research 2Health News:East Brunswick Native Returns Home to Help New Jersey Residents Living with MS 2
(Date:10/19/2014)... 2014  Henry Schein, Inc. (NASDAQ: HSIC ... and services to office-based dental, animal health and medical ... Dental Supply, Inc., a leading full-service provider of dental ... Schein,s entrance into Japan , the ... to 28 the number of countries in which the ...
(Date:10/17/2014)... 2014  Training market researchers to spot and ... in today,s highly competitive global marketplace. As resources ... effectively and efficiently produce high performing analysts, regardless ... Effective training programs can help these ... internal clients by developing analysts who can drive ...
(Date:10/17/2014)... 2014 ... the addition of the  "China Interventional Cardiovascular ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... China impacted by accelerated ... concept, dietary habit, way of working and ...
Breaking Medicine Technology:Henry Schein Enters Japan With Investment in Iwase Dental Supply 2Henry Schein Enters Japan With Investment in Iwase Dental Supply 3Henry Schein Enters Japan With Investment in Iwase Dental Supply 4Henry Schein Enters Japan With Investment in Iwase Dental Supply 5Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2China Interventional Cardiovascular Device Industry Report 2014-2017 2China Interventional Cardiovascular Device Industry Report 2014-2017 3
The Precedent establishes a new generation of revision hip stems....
The Natural-Hip combines the surgical simplicity of a straight stem with many of the best features of an anatomic stem....
Calcar replacement stems provide options for revision and trochanteric fractures. Revision hip surgery and trauma often require prosthetic designs that replace proximal medial calcar bone loss....
... materials contributes to successful outcomes for ... procedures and technique, the materials you ... your patients' outcomes, both short-term and ... Cross-Linked Polyethylene. MARATHON Polyethylene is the ...
Medicine Products: