Navigation Links
Safety of Cancer Therapeutic Viruses Enhanced

Cancer killing viruses have been made more specific to cancer tumor cells in addition to enhancing its therapeutic effectiveness by Mayo Clinic researchers working with colleagues in Germany.//

This was a much-needed multilevel safety feature for viruses used to treat cancer. They did this by engineering a modified measles virus that turns on only in the presence of secretions specific to malignant cancer cells.

In effect, the Mayo Clinic virus makeover uses proteins secreted by cancer cells as the unique key to the virus' ignition. Their report on the topic appears in the Aug. 1 edition of Cancer Research (http://cancerres.aacrjournals.org).

The investigation was performed in laboratory mice that were transplanted with a human cancer. The process is still experimental -- and thus, years away from clinical use in humans. However, the Mayo results may be immediately useful in designing improved cancer treatments for humans. "Our work shows that oncolytic measles virus particle activation can be made dependent on substances secreted by cancer cells, and this enhances safety," explains Roberto Cattaneo, Ph.D., lead researcher on the Mayo team. "By doing this, our study broadens the safeguarding strategies possible to tightly restrict the targeted virus to cancer cells."

Significance of the Mayo Clinic Research The Mayo researchers say their contribution is a key advance because it provides a method of designing a therapeutic virus that is safe, stable and that reliably targets and kills cancer cells. Importantly, it appears to greatly reduce the possibility that the virus would erroneously turn on and harm the patient by causing unintended infection.

As such, the Mayo innovation of the cancer-activated virus is a helpful safety advance for the promising experimental field of "oncolytic virotherapy." The phrase refers to the natural ability of certain viruses to kill cancer cells. It's a promising approach that h as been known for nearly a century -- but constrained by safety concerns. Measles virus is one example of an oncolytic virus. For example, the live attenuated Edmonston measles vaccine strain can reduce or eliminate human lymphoma, myeloma, ovarian cancer and glioma tumors that are transplanted into laboratory mice.

Enhanced Safety and Effectiveness The success of oncolytic virotherapy depends on restriction of viral growth to cancer cells --and only cancer cells -- to prevent unintended rogue infections elsewhere in the healthy body. The Mayo cancer-activated virus adds one more layer to a multiple safeguard system, so it now consists of three levels. The resulting enhanced security system now works at the level of:

activation of the virus particle

receptor recognition necessary for the virus to enter a cancer cell

ability of the virus to multiply preferentially in cancer cells

These multiple safeguards are specific to and dependent on cancer cells -- and are therefore vital to fully transforming viruses into safe therapeutic agents.

Source:Eurekalert
'"/>




Related medicine news :

1. New standards for Human Research Safety
2. Safety of soy under suspicion
3. The Safety Of Prenatal Ultrasounds Questioned
4. Report on the Safety and Effectiveness of Melatonin supplements
5. Monitoring Drug Safety
6. Safety Of Indian Sex Workers At Risk Due To Poor Condom Usage
7. Safety Of Heart Drug Questioned
8. Race Was Used To Determine Safety Of Blood
9. Patient Safety Forces Closure Of Hospital
10. Farm Boy Airlifted by PSNI helicopter To Safety
11. Strict Safety Measures On Import of Poultry From China
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
(Date:6/25/2016)... ... ... Bruton Memorial Library on June 21 due to a possible lice infestation, as reported by ... lice: the parasite’s ability to live away from a human host, and to infest common ... the event that lice have simply gotten out of control. , As lice are a ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin ... companies that call for a minimum wage raise to $12 an hour by 2020 and ... This will restore the lost value of the minimum wage, assure the wage floor does ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
Breaking Medicine Technology: