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STIs Significantly Increase Risk of Drug-resistant HIV Transmission

The researchers did not find any significant associations between TDR and recreational drug use, number of sexual partners, or report of unprotected intercourse, or between STIs and mutations thought to confer reduced viral fitness. The investigators state that “[in] this cohort of predominantly MSM we have demonstrated that TDR is significantly associated with the presence of an acute STI. The high prevalence of STIs in those with recent HIV infection and their effect in increasing viral shedding strongly supports the need for routine STI screening in those newly diagnosed with HIV and the need for close cooperation between HIV and STI services.” Further analysis of viral replication fitness is investigating whether STIs may help transmission of “less fit” virus; however, “interpretation of genotypic results thus far does not support this.”

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