Navigation Links
STIs Significantly Increase Risk of Drug-resistant HIV Transmission

A study of people newly diagnosed with HIV in the UK has found that sexually transmitted infections (STIs) are strongly associated with the transmission of antiretroviral-resistant HIV. //

Researchers from two UK hospitals and the Health Protection Agency have investigated the connection between two phenomena: sexually transmitted diseases (STIs) as a factor in HIV transmission, and the transmission of drug-resistant HIV. Sexually transmitted diseases in either or both sexual partners make HIV transmission more likely – probably due to a combination of factors, including increased HIV shedding and greater susceptibility of sexual mucous membranes.

The transmission of antiretroviral drug-resistant HIV is also well-documented: studies have shown that it occurs frequently in the UK.

This study, presented last week at the Fourteenth Conference on Retroviruses and Opportunistic Infections in Los Angeles, looked at 185 cases of primary HIV infection (infections acquired during the preceding six months), culled from 604 new HIV diagnoses made between 2000 and 2005. These cases were nearly all in white gay and bisexual men: of the 185, 175 (95%) were white, 174 (94%) were male and 169 (96% of the males) were men who have sex with men (MSM). The median age was 34 years.

Genotypic resistance testing was performed on blood samples from all individuals; 28 (15%) were found to have resistance mutations based on IAS 2005 definitions – a figure comparable to similar UK studies. A variety of resistance patterns were identified, predominantly NRTI or NNRTI resistance (61% and 43% respectively); PI and multi-class resistance were found in 2 cases (7%) each.

One hundred and twenty-four (67%) of the participants were screened for STIs at HIV diagnosis or within the preceding three months; there was essentially no difference in screening frequency between the groups with and without transmitted drug resistance (TDR).

The researchers did not find any significant associations between TDR and recreational drug use, number of sexual partners, or report of unprotected intercourse, or between STIs and mutations thought to confer reduced viral fitness. The investigators state that “[in] this cohort of predominantly MSM we have demonstrated that TDR is significantly associated with the presence of an acute STI. The high prevalence of STIs in those with recent HIV infection and their effect in increasing viral shedding strongly supports the need for routine STI screening in those newly diagnosed with HIV and the need for close cooperation between HIV and STI services.” Further analysis of viral replication fitness is investigating whether STIs may help transmission of “less fit” virus; however, “interpretation of genotypic results thus far does not support this.”

Source-Bio-Bio TechnologyBR>SRM

Related medicine news :

1. Violence at Work Significantly Boosts Clinical Depression Risk
2. Computer-Driven System Reduces Patient Mechanical Ventilation Time Significantly
3. New Study: Pine Bark Significantly Reduces Endometriosis
4. Use of Cellular Phones associated with Increased risk of Brain Tumors
5. Increase in sugar...decrease in brain function!!!
6. Increase in tobacco deaths
7. Increased Heart Attack Risk From Celebrex,Vioxx
8. Deep Sleep Doesnt Increase Memory
9. Allergy Risk Increased by Kerosene Use
10. IVF technique May Increase The Risk Of Birth Defects
11. Step Aerobics Increases good cholesterol
Post Your Comments:

(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell ... pain and the benefits of holistic treatments, Serenity Recovery Center of Marne, ... Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for ... $12 an hour by 2020 and then adjusting it yearly to increase at the same ... wage, assure the wage floor does not erode again, and make future increases more predictable. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... a startling report released today, National Safety Council research ... proven plan to eliminate prescription opioid overdoses. Prescription Nation ... tackling the worst drug crisis in recorded U.S. history, assigned a ... , New Mexico , Tennessee ... failing states, three – Michigan , ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: