Navigation Links
STIs Significantly Increase Risk of Drug-resistant HIV Transmission

A study of people newly diagnosed with HIV in the UK has found that sexually transmitted infections (STIs) are strongly associated with the transmission of antiretroviral-resistant HIV. //

Researchers from two UK hospitals and the Health Protection Agency have investigated the connection between two phenomena: sexually transmitted diseases (STIs) as a factor in HIV transmission, and the transmission of drug-resistant HIV. Sexually transmitted diseases in either or both sexual partners make HIV transmission more likely – probably due to a combination of factors, including increased HIV shedding and greater susceptibility of sexual mucous membranes.

The transmission of antiretroviral drug-resistant HIV is also well-documented: studies have shown that it occurs frequently in the UK.

This study, presented last week at the Fourteenth Conference on Retroviruses and Opportunistic Infections in Los Angeles, looked at 185 cases of primary HIV infection (infections acquired during the preceding six months), culled from 604 new HIV diagnoses made between 2000 and 2005. These cases were nearly all in white gay and bisexual men: of the 185, 175 (95%) were white, 174 (94%) were male and 169 (96% of the males) were men who have sex with men (MSM). The median age was 34 years.

Genotypic resistance testing was performed on blood samples from all individuals; 28 (15%) were found to have resistance mutations based on IAS 2005 definitions – a figure comparable to similar UK studies. A variety of resistance patterns were identified, predominantly NRTI or NNRTI resistance (61% and 43% respectively); PI and multi-class resistance were found in 2 cases (7%) each.

One hundred and twenty-four (67%) of the participants were screened for STIs at HIV diagnosis or within the preceding three months; there was essentially no difference in screening frequency between the groups with and without transmitted drug resistance (TDR).

The researchers did not find any significant associations between TDR and recreational drug use, number of sexual partners, or report of unprotected intercourse, or between STIs and mutations thought to confer reduced viral fitness. The investigators state that “[in] this cohort of predominantly MSM we have demonstrated that TDR is significantly associated with the presence of an acute STI. The high prevalence of STIs in those with recent HIV infection and their effect in increasing viral shedding strongly supports the need for routine STI screening in those newly diagnosed with HIV and the need for close cooperation between HIV and STI services.” Further analysis of viral replication fitness is investigating whether STIs may help transmission of “less fit” virus; however, “interpretation of genotypic results thus far does not support this.”

Source-Bio-Bio TechnologyBR>SRM
'"/>




Related medicine news :

1. Violence at Work Significantly Boosts Clinical Depression Risk
2. Computer-Driven System Reduces Patient Mechanical Ventilation Time Significantly
3. New Study: Pine Bark Significantly Reduces Endometriosis
4. Use of Cellular Phones associated with Increased risk of Brain Tumors
5. Increase in sugar...decrease in brain function!!!
6. Increase in tobacco deaths
7. Increased Heart Attack Risk From Celebrex,Vioxx
8. Deep Sleep Doesnt Increase Memory
9. Allergy Risk Increased by Kerosene Use
10. IVF technique May Increase The Risk Of Birth Defects
11. Step Aerobics Increases good cholesterol
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, ... M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... the most handsome men, look naturally attractive. Plastic surgery should be invisible.” He ...
(Date:6/24/2016)... ... 2016 , ... Today, MTI-GlobalStem, a provider of optimized transfection ... to transfect cells, announces its launch of the PluriQ™ G9™ Gene Editing System ... is a complete system for culturing and transfecting human pluripotent stem cells for ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016  Experian Health, the healthcare industry ... patient payment and care experience, today announced ... and services that will enhance the breadth ... These award-winning solutions will enable healthcare professionals ... in an ever-changing environment and redefine front-office ...
(Date:6/23/2016)... 2016  The National Pharmaceutical Council (NPC) today ... policy research organization as its newest member.  ... vice president and chief scientific officer, Mallinckrodt Pharmaceuticals, ... NPC Board of Directors. ... joined us in support of our efforts to ...
(Date:6/23/2016)... , June 23, 2016  Delcath Systems, Inc. (NASDAQ: ... device company focused on treatment of primary and metastatic ... European patient education - www.againsttheodds.eu - has ... Digital Health Awards. The website ... European patients and their families who are coping with ...
Breaking Medicine Technology: