Navigation Links
STIs Significantly Increase Risk of Drug-resistant HIV Transmission

A study of people newly diagnosed with HIV in the UK has found that sexually transmitted infections (STIs) are strongly associated with the transmission of antiretroviral-resistant HIV. //

Researchers from two UK hospitals and the Health Protection Agency have investigated the connection between two phenomena: sexually transmitted diseases (STIs) as a factor in HIV transmission, and the transmission of drug-resistant HIV. Sexually transmitted diseases in either or both sexual partners make HIV transmission more likely – probably due to a combination of factors, including increased HIV shedding and greater susceptibility of sexual mucous membranes.

The transmission of antiretroviral drug-resistant HIV is also well-documented: studies have shown that it occurs frequently in the UK.

This study, presented last week at the Fourteenth Conference on Retroviruses and Opportunistic Infections in Los Angeles, looked at 185 cases of primary HIV infection (infections acquired during the preceding six months), culled from 604 new HIV diagnoses made between 2000 and 2005. These cases were nearly all in white gay and bisexual men: of the 185, 175 (95%) were white, 174 (94%) were male and 169 (96% of the males) were men who have sex with men (MSM). The median age was 34 years.

Genotypic resistance testing was performed on blood samples from all individuals; 28 (15%) were found to have resistance mutations based on IAS 2005 definitions – a figure comparable to similar UK studies. A variety of resistance patterns were identified, predominantly NRTI or NNRTI resistance (61% and 43% respectively); PI and multi-class resistance were found in 2 cases (7%) each.

One hundred and twenty-four (67%) of the participants were screened for STIs at HIV diagnosis or within the preceding three months; there was essentially no difference in screening frequency between the groups with and without transmitted drug resistance (TDR).

The researchers did not find any significant associations between TDR and recreational drug use, number of sexual partners, or report of unprotected intercourse, or between STIs and mutations thought to confer reduced viral fitness. The investigators state that “[in] this cohort of predominantly MSM we have demonstrated that TDR is significantly associated with the presence of an acute STI. The high prevalence of STIs in those with recent HIV infection and their effect in increasing viral shedding strongly supports the need for routine STI screening in those newly diagnosed with HIV and the need for close cooperation between HIV and STI services.” Further analysis of viral replication fitness is investigating whether STIs may help transmission of “less fit” virus; however, “interpretation of genotypic results thus far does not support this.”

Source-Bio-Bio TechnologyBR>SRM
'"/>




Related medicine news :

1. Violence at Work Significantly Boosts Clinical Depression Risk
2. Computer-Driven System Reduces Patient Mechanical Ventilation Time Significantly
3. New Study: Pine Bark Significantly Reduces Endometriosis
4. Use of Cellular Phones associated with Increased risk of Brain Tumors
5. Increase in sugar...decrease in brain function!!!
6. Increase in tobacco deaths
7. Increased Heart Attack Risk From Celebrex,Vioxx
8. Deep Sleep Doesnt Increase Memory
9. Allergy Risk Increased by Kerosene Use
10. IVF technique May Increase The Risk Of Birth Defects
11. Step Aerobics Increases good cholesterol
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... ... May 05, 2016 , ... LELO has ... Every day, LELO fans reach out via email, social media and on the Volonté ... up: “Is the way I masturbate ‘normal’ or ‘correct’?” , While some methods are ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... in all U.S. states and certain Canadian provinces is now available from the ... Research Institute (WCRI). , The report, Workers’ Compensation Laws as of ...
(Date:5/5/2016)... ... 2016 , ... Long Island’s fastest growing comprehensive eye care provider, North ... Kathleen Van Valkenburg, MD as part of their ongoing effort to increase ophthalmic coverage ... managing partner of North Shore Eye Care. , “We are extremely proud to ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... resources for veterinary professionals across the United States. The whole food nutrient solutions ... their patients and giving dog, cat and horse owners’ peace of mind. With ...
(Date:5/5/2016)... Woodinville, WA (PRWEB) , ... May 05, 2016 ... ... better user experience, adapted to people’s every day living patterns, Amerec, a Seattle-based ... easy-to-use computer and smart phone app. , The user interface of the app, ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... has acquired a major investment from Sino-German High-Tech Fund to further expand product development, strengthen its disease modeling capabilities ... ... ... ... ...
(Date:5/3/2016)... Ore. , May 3, 2016   ... medical technology, today announced Food and Drug Administration ... resynchronization defibrillator that provides heart failure patients with ... Iperia devices also have remote monitoring with daily ... adapts the heart rate in response to physiological ...
(Date:5/3/2016)...   Diplomat Pharmacy, Inc. (NYSE: DPLO) announced today that it is celebrating Hepatitis Awareness Month ... patients who tell their personal story and encourage those at risk to get tested and ... C ... ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ...
Breaking Medicine Technology: