Navigation Links
Run Amok Enzyme Causes Same Problems in Both Humans and Fruit Flies

An enzyme found at elevated levels in several human cancers has been linked to abnormal tumor growth in fruit flies//, a discovery that provides a new model for understanding the link between stem cell biology and cancer, according to researchers.

Using fluorescent staining and laser-scanning microscopy, the eight-member research team studied various mutations in a gene called aurora-A to observe how changes in protein expression affected the ability of Drosophila neuroblasts, a type of neural stem cell, to maintain their stem cell character without forming tumors.

Reporting in the Dec. 20 issue of the journal Genes & Development, Chris Doe and colleagues detail how an overproduction of renewed neuroblasts in the flies can be traced to misregulation by the aurora-A kinase. This enzyme under normal conditions appears to be critical as a traffic cop for various proteins during mitosis in neuroblasts, they concluded.

“In humans, there has been a lot of thought that maybe stem cell populations are at the heart of many cancers,” said Ryan O. Andersen, a doctoral student in Doe’s lab. “The numbers are off drastically. Instead of properly dividing, they are overproducing more stem cells rather than maintaining a steady population. This loss of regulation leads to tumors populated with these overproduced cells.”

Andersen and Cheng-Yu Lee, a postdoctoral fellow, were lead authors on the paper. Doe, a Howard Hughes Medical Institute investigator, is a professor of biology in the UO Institute of Neuroscience and Institute of Molecular Biology.

In Drosophila, Doe’s team found that a mutation in aurora-A, an evolutionary conserved gene in fruit flies and humans, results in two distinguishing problems: Proteins (Numb) involved in the differentiation into neurons and neuroblast self-renewal (aPKC) are not sorted to their proper sides of the cell, and the mitotic spindle that provides cortical polarity becomes misaligned. T
'"/>




Page: 1 2

Related medicine news :

1. Enzyme may be target for obesity drugs
2. Researchers trick Alzheimers Enzyme
3. Enzyme stimulates growth of adult stem cells
4. Enzyme may aid hold back disease
5. Enzyme help destroy cancer cell
6. Enzyme Associated with Memory
7. Enzyme Associated With Memory
8. Brain Enzyme Found To Regulate Weight
9. New Enzyme Identified For Arthritis
10. Enzyme for treatment of arthritis
11. An Enzyme That Turns a One –time Experience into a long-time Memor
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Run Amok Enzyme Causes Same Problems Both Humans and Fruit Flies

(Date:7/28/2015)... ... July 29, 2015 , ... Talking About Your Product Pipeline:, How FDA and ... 3:00 p.m. EDT, http://www.fdanews.com/productpipeline , When a company has a product in ... about it is tightly regulated by the FDA. , At the same time, the ...
(Date:7/28/2015)... ... July 29, 2015 , ... The insurance telematics or ... This would allow insurers to access the on-board vehicle data and better understand customer ... it comes to sharing vehicle data. However times are changing and automakers realize that ...
(Date:7/28/2015)... Ill. (PRWEB) , ... July 28, 2015 , ... A ... commended with a national 2015 Power of A award for “helping to make the ... Power of A Gold Award winner by the American Society of Association Executives. Power ...
(Date:7/28/2015)... ... ... Mindful Her, a unique women’s wellness and lifestyle event designed to inspire and ... the next level, announced today an influential line-up of inspiring speakers, including Mallika Chopra, ... an Orange County based non-profit that works locally and globally to help girls become ...
(Date:7/28/2015)... (PRWEB) , ... July 28, 2015 , ... ... through October this year, as volunteers celebrate the 14th year of raising money ... Tracy Lawrence in downtown Savannah for this year’s main concert Saturday, Oct. 3. ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 2Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 3Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 4Health News:General Motors Engaging Insurance Partners for the Connected Car 2Health News:General Motors Engaging Insurance Partners for the Connected Car 3Health News:ASDS Skin Cancer Program Honored 2Health News:ASDS Skin Cancer Program Honored 3Health News:Women’s Healthy Living Event Mindful Her Set for October 24, 2015 in Orange County 2Health News:Women’s Healthy Living Event Mindful Her Set for October 24, 2015 in Orange County 3Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 2Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 3
... Advisers say current labeling doesn,t reflect reports of bizarre ... (HealthDay News) -- A U.S. Food and Drug ... drug Tamiflu (oseltamivir) should have a stronger warning label ... children who use the medication. , The FDA,s Pediatric ...
... "mursa,",methicillin-resistant staphylococcus aureus (MRSA) is one of the worst,infections-a ... It has,killed the elderly, babies, toddlers, teenagers and even ... schools., One of the most common places MRSA ... start innocently, perhaps with a nick or cut. You,might ...
... Robert Scott, a leading,retainer-based executive search firm; ... services; and the internationally recognized law firm ... Business School,have released data for their 2007 ... at http://www.compstudy.com . This study is ...
... 27 Going through airport security,can be such ... all,get taken off, taken out, scanned, examined, handled ... electromagnetic radiation, may reshape,not only airport screening procedures ... the U.S. Department of Energy,s Argonne National,Laboratory, along ...
... 27 A story published today in,The Wall ... habit of,co-workers indiscriminately hitting the "reply to all" ... leader Best Practices, LLC,uncovered a similar problem that ... organizations to send redundant announcements to sales reps ...
... Nov. 27 The Aesthetic Extender,Symposium announced its inaugural ... which will be held in Miami Beach,Florida on October ... the first,and only event of its kind. Unlike other ... its mission statement a goal of adhering to,the policies ...
Cached Medicine News:Health News:FDA Panel Backs Tougher Warning for Tamiflu 2Health News:FDA Panel Backs Tougher Warning for Tamiflu 3Health News:New Booklet Reveals 12 Proven Methods for Stopping MRSA from Infecting Your Feet and Your Family's Feet 2Health News:2007 Life Sciences Compensation Findings Disclosed www.compstudy.com 2Health News:2007 Life Sciences Compensation Findings Disclosed www.compstudy.com 3Health News:2007 Life Sciences Compensation Findings Disclosed www.compstudy.com 4Health News:New T-ray Source Could Improve Airport Security, Cancer Detection 2Health News:New T-ray Source Could Improve Airport Security, Cancer Detection 3Health News:New T-ray Source Could Improve Airport Security, Cancer Detection 4Health News:Using Efficient Communication to Boost Pharma Sales Force Productivity 2
(Date:7/28/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cng4gn/refurbished ) has announced the ... Global Forecasts to 2019" report to their offering. ... estimated to grow expected to reach $9.37 billion by ... 2019. Factors such as growing ... increasing privatization in the healthcare sector, and rising adoption ...
(Date:7/28/2015)... July 28, 2015  PD-Rx Pharmaceuticals, Inc., a ... it has partnered with Dobson Technologies, a fully-integrated ... Service (IaaS) product. PD-Rx is an ... the United States.  Using Dobson Technologies, IaaS solution ... business continuity, ensure regulatory compliance, and reduce operating ...
(Date:7/28/2015)... Fla. , July 28, 2015  For many ... their researchers, physicians and other inventors can be a ... market is difficult, and successes are rare. ... wants to change that. Medical Device Investments ... licensed from universities, hospitals and physicians. MDI develops, manufactures ...
Breaking Medicine Technology:Refurbished Medical Equipment Market 2015 - Global Forecasts to 2019 2PD-Rx Partners With Dobson Technologies 2Medical Device Investments To Become Center Of Excellence For The Commercialization Of Innovative Medical Technologies 2
... Texas Children,s Hospital and SynCardia Systems, Inc. announced today ... hospital to complete the first phase of certification to ... intends to use the Total Artificial Heart as a ... heart transplant as children and now require mechanical support ...
... 2011 As the biopharmaceutical marketplace has evolved, leading ... to change as well. Specifically, Market Research is shifting ... shaping strategic objectives for key commercial groups. ... increasingly use new and innovative tools such as Webcams ...
Cached Medicine Technology:Texas Children's Is First Pediatric Hospital To Begin Certification Process for SynCardia's Total Artificial Heart 2Texas Children's Is First Pediatric Hospital To Begin Certification Process for SynCardia's Total Artificial Heart 3Strategic Role Becoming Critical Part of Market Research Function 2
...
...
... At the entry-level, Philips Zymed 1810 Series ... preview, which gives the operator the flexibility ... complex arrhythmia. Choose an application beyond the ... flexibility. Select the interactive or automatic style ...
... Holter Software for Windows is a ... to install, use and maintain as ... comprehensive as a cardiograph., ,Full ... and QuickScan, which combines the benefits ...
Medicine Products: