Navigation Links
Run Amok Enzyme Causes Same Problems in Both Humans and Fruit Flies

An enzyme found at elevated levels in several human cancers has been linked to abnormal tumor growth in fruit flies//, a discovery that provides a new model for understanding the link between stem cell biology and cancer, according to researchers.

Using fluorescent staining and laser-scanning microscopy, the eight-member research team studied various mutations in a gene called aurora-A to observe how changes in protein expression affected the ability of Drosophila neuroblasts, a type of neural stem cell, to maintain their stem cell character without forming tumors.

Reporting in the Dec. 20 issue of the journal Genes & Development, Chris Doe and colleagues detail how an overproduction of renewed neuroblasts in the flies can be traced to misregulation by the aurora-A kinase. This enzyme under normal conditions appears to be critical as a traffic cop for various proteins during mitosis in neuroblasts, they concluded.

“In humans, there has been a lot of thought that maybe stem cell populations are at the heart of many cancers,” said Ryan O. Andersen, a doctoral student in Doe’s lab. “The numbers are off drastically. Instead of properly dividing, they are overproducing more stem cells rather than maintaining a steady population. This loss of regulation leads to tumors populated with these overproduced cells.”

Andersen and Cheng-Yu Lee, a postdoctoral fellow, were lead authors on the paper. Doe, a Howard Hughes Medical Institute investigator, is a professor of biology in the UO Institute of Neuroscience and Institute of Molecular Biology.

In Drosophila, Doe’s team found that a mutation in aurora-A, an evolutionary conserved gene in fruit flies and humans, results in two distinguishing problems: Proteins (Numb) involved in the differentiation into neurons and neuroblast self-renewal (aPKC) are not sorted to their proper sides of the cell, and the mitotic spindle that provides cortical polarity becomes misaligned. T he subsequent splitting leads to new cells with improper proteins mixes, including an overproduction – in this case 10 times more than normal – of new neuroblasts that lead to tumors in the brain.

“We conclude that the aurora-A kinase is required to coordinate the position of proteins within the neuroblasts,” Doe said. “When it is absent, too little neuron-promoting proteins are delivered into the young neurons and they never lose their stem-cell nature. This leads to a stem-cell tumor in the fly brain.”

The team’s findings appear to reverse traditional thinking that too much activation of aurora-A leads to tumors, including those in more than half of colorectal cancers. Instead, Doe and colleagues argue that aurora-A and numb are tumor suppressants under normal conditions, and that a loss of aurora-A is what prompts overproduction of new neuroblasts and, thus, tumor development.

Source-Newwise
SRM
'"/>




Related medicine news :

1. Enzyme may be target for obesity drugs
2. Researchers trick Alzheimers Enzyme
3. Enzyme stimulates growth of adult stem cells
4. Enzyme may aid hold back disease
5. Enzyme help destroy cancer cell
6. Enzyme Associated with Memory
7. Enzyme Associated With Memory
8. Brain Enzyme Found To Regulate Weight
9. New Enzyme Identified For Arthritis
10. Enzyme for treatment of arthritis
11. An Enzyme That Turns a One –time Experience into a long-time Memor
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2016)... , ... May 02, 2016 , ... ... a residential inpatient rehabilitation center can find some useful information in a new ... in Central Michigan. This video, which can be viewed on the Serenity Recovery ...
(Date:5/2/2016)... ... 2016 , ... Beanfields, PBC, makers of Beanfields Bean and ... at University of Colorado in Boulder to create new advertising campaigns. , Adjunct ... School of Journalism, who selected Beanfields as the brand on which to focus ...
(Date:5/2/2016)... Texas (PRWEB) , ... May 02, 2016 , ... In ... will offer an incentive to people who share their fitness journey on social ... and premium first aid products, will award a $100 product voucher each week during ...
(Date:5/2/2016)... ... 2016 , ... East Los Angeles dentist , Dr. Ramin Assili, is ... to receive any dental extraction treatment for $40 off the regular price. This promotion ... the lower price, patients can more easily afford extractions to eliminate teeth that are ...
(Date:5/2/2016)... ... ... Dr. Rassouli, dentist in Orange County, CA comments on the ... was published in the “Journal of the American Geriatrics Society,” more than a third ... Alzheimer’s disease. The study found that dental problems may increase the risk of heart ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016 Treato , the ... announced today that it has been named a Cool ... in Life Sciences, 2016, Stephen Davies , ... focuses on life-science- oriented analytics, algorithms and smart machine ... doctors, confirm medication ingestion, and analyze unstructured information.   ...
(Date:4/28/2016)... Dr. Vivek Ahuja , ... Ste phen Schmidt ... of cloud-based software solutions for life sciences, today announced key new ... wealth of insight to a growing business.  This will bolster the ... George Phillips joined ArisGlobal in the position of Vice President ...
(Date:4/28/2016)... N.J. , April 28, 2016   Acsis ... today announced that leading IT market research and advisory ... " in the IDC MarketScape: Worldwide Pharmaceutical Track and ... 2016).  The report provides an assessment of the capabilities ... track and trace software market. Logo - ...
Breaking Medicine Technology: