Navigation Links
Ruboxistaurin (RBX) may prevent vision loss in diabetic patients

Phase III clinical trial of Ruboxistaurin (RBX) at a concentration of 32 milligrams/day// was found to inhibit Protein kinase C (PKC) – beta inhibitor, which was found to cause vision loss in patients with diabetes.

The study was conducted in 252 patients with type 1 or type 2 diabetes by the Research team of Joslin Diabetes Centre across United States, Canada, Denmark, Netherlands and United Kingdom. The study was named as PKS-DRS, (Protein Kinase C – Diabetic Retinopathy Study), was done to evaluate the oral administration of RBX and placebo over a period of 3-4 years at a concentration of 8, 16 or 32 mg/day.

Incidence of eye complications is high in Diabetic patients, with common complications of diabetes causing diabetic retinopathy and diabetic macular edema. Diabetic retinopathy is characterised by damage to small blood vessels in the retina and causes severe vision loss. Diabetic macular edema is characterised by leaky blood vessels with swelling in the retina.

Protein kinase C is required for the normal production of energy in the body, but a-form of PKC has found to cause diabetic complications of the eye. a- PKC is the major signaling pathway which is stimulated by high blood glucose levels. In animal studies it was found that the abnormal activation of a-PKC decreases the blood flow to the retina.

The research team has found oral administration of 32 milligrams/day of Ruboxistaurin, blocks the activity of a-Protein kinase C. Moreover, RBX was found to be specific in binding only to the a-form of PKC. Though, RBX does not prevent the progression of diabetic retinopathy, it reduces the vision loss which is caused by macular edema. RBX in the study group did not produce any side-effects.
'"/>




Page: 1

Related medicine news :

1. Ruboxistaurin As A Novel Treatment For Diabetic Nephropathy
2. Asthma may actually be prevented by Dust and Dirt
3. Nearly all asthma deaths preventable
4. Breast Feeding prevents obesity later on in life
5. Regular exercise prevents hip fractures
6. Gel prevents pregnancy
7. Arterial stiffness prevented by light drinking
8. How to prevent wrinkles?
9. Re-blockage of heart arteries prevented by vitamins
10. Early delivery can prevent cancer
11. Hobbies prevent dementia
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the ... a year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, ... retirement havens have extremely low property-tax rates, which contributes to the relatively lower ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its ... on Friday, November 3, 2017, beginning at 7:00 a.m. ... 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... and guidance for 2018, Hill-Rom executives will also highlight ... and long-range financial outlook through 2020. ...
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017  DarioHealth ... and big data solutions, today announced that its MyDario product is expected ... local TV listings for when The Dr. Oz Show airs in your ... The nine-time Emmy ... ...
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
Breaking Medicine Technology: