Navigation Links
Ruboxistaurin (RBX) may prevent vision loss in diabetic patients

Phase III clinical trial of Ruboxistaurin (RBX) at a concentration of 32 milligrams/day// was found to inhibit Protein kinase C (PKC) – beta inhibitor, which was found to cause vision loss in patients with diabetes.

The study was conducted in 252 patients with type 1 or type 2 diabetes by the Research team of Joslin Diabetes Centre across United States, Canada, Denmark, Netherlands and United Kingdom. The study was named as PKS-DRS, (Protein Kinase C – Diabetic Retinopathy Study), was done to evaluate the oral administration of RBX and placebo over a period of 3-4 years at a concentration of 8, 16 or 32 mg/day.

Incidence of eye complications is high in Diabetic patients, with common complications of diabetes causing diabetic retinopathy and diabetic macular edema. Diabetic retinopathy is characterised by damage to small blood vessels in the retina and causes severe vision loss. Diabetic macular edema is characterised by leaky blood vessels with swelling in the retina.

Protein kinase C is required for the normal production of energy in the body, but a-form of PKC has found to cause diabetic complications of the eye. a- PKC is the major signaling pathway which is stimulated by high blood glucose levels. In animal studies it was found that the abnormal activation of a-PKC decreases the blood flow to the retina.

The research team has found oral administration of 32 milligrams/day of Ruboxistaurin, blocks the activity of a-Protein kinase C. Moreover, RBX was found to be specific in binding only to the a-form of PKC. Though, RBX does not prevent the progression of diabetic retinopathy, it reduces the vision loss which is caused by macular edema. RBX in the study group did not produce any side-effects.

Page: 1

Related medicine news :

1. Ruboxistaurin As A Novel Treatment For Diabetic Nephropathy
2. Asthma may actually be prevented by Dust and Dirt
3. Nearly all asthma deaths preventable
4. Breast Feeding prevents obesity later on in life
5. Regular exercise prevents hip fractures
6. Gel prevents pregnancy
7. Arterial stiffness prevented by light drinking
8. How to prevent wrinkles?
9. Re-blockage of heart arteries prevented by vitamins
10. Early delivery can prevent cancer
11. Hobbies prevent dementia
Post Your Comments:

(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... Those ... deal with these feelings, many turn to unhealthy avenues, such as drug or alcohol ... of Marne, Michigan, has released tools for healthy coping following a traumatic event. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has ... Global Analysis (United States, China, Japan, Brazil, United Kingdom, ... their offering. Surgical ... business planners, provides surgical procedure volume data in a ... an in-depth analysis of growth drivers and inhibitors, including ...
(Date:6/23/2016)... -- The Biotechnology industry might still be ... opportunities to investors. assesses the recent performances of ... XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ), and Regeneron Pharmaceuticals Inc. (NASDAQ: REGN ... complimentary trade alerts at: ...
(Date:6/23/2016)... Leading BioSciences Inc., a clinical-stage biopharmaceutical ... from a breakdown of the mucosal barrier, today ... as chief executive officer. Mr. Doyle, a ... and board of directors, previously served as chief ... provide continued leadership and strategic direction to the ...
Breaking Medicine Technology: