Navigation Links
Role of Appetite Hormone MCH in Insulin Production Revealed

A new Joslin Diabetes Center-led study has shown conclusively that a neuropeptide, melanin concentrating hormone (MCH), found in the brain and known for its role in// increasing appetite in people, plays a role in the growth of insulin-producing beta cells and the secretion of insulin. This finding has the potential to spur the development of new treatments for diabetes that stimulate the production of insulin-producing beta cells in the pancreas.

An earlier Joslin-led study examined the connection between obesity and MCH, which plays a critical role in energy balance and appetite, observing an increase in the number of beta cells when MCH levels are high. This was a new finding that had not been observed before. Although MCH’s role in appetite control is well known, its effects on the secretion of endocrine hormones has not been fully understood.

“It’s a very logical connection,” says Rohit N. Kulkarni, M.D., Ph.D., investigator at Joslin Diabetes Center and Assistant Professor of Medicine at Harvard Medical School, who led the study. “Whenever you eat food, your body needs more insulin. When MCH induces appetite, it simultaneously increases insulin secretion from beta cells and enhances growth of beta cells. If the proteins that mediate the growth mechanism can be identified, it could lead to the development of new drugs that would enhance beta cell growth to treat type 1 and type 2 diabetes.”

In type 1 diabetes (insulin-dependent) diabetes, which accounts for 5 to 10 percent (between 700,000 and 1.4 million people) of diabetes cases in the United States, an autoimmune process has destroyed the insulin-producing islet cells in the pancreas. In type 2 diabetes, the far more common form of the disease, the body doesn’t produce enough insulin and/or can’t use insulin properly (insulin resistance). Both diseases could benefit from treatments that stimulate beta cells in the pancreas to produce insulin.

In the first stu dy, in which mice were genetically engineered to over-express MCH, Dr. Kulkarni and his colleagues observed changes in beta cell mass out of proportion with the degree of obesity, suggesting that MCH had a direct effect on islets. To build on these previous findings, the researchers focused this study on gaining a deeper understanding of how MCH and its receptors influence growth of beta cells.

The investigators first confirmed that MCH and its receptors are indeed expressed in islet cells of mice and humans. They then treated human donor or mouse pancreatic islet cells with MCH and found that it increased insulin secretion, compared to islet cells without MCH, which did not show the same effect.

In the next phase, the researchers examined genetically-engineered mice that did not produce MCH and consequently had abnormally small islets. “This indicated to us that MCH is important for growth of islets,” says Dr. Kulkarni.

The next step in the research process is to pinpoint exactly how MCH is regulating the growth of beta cells and identify which proteins are involved in this growth process. “We know MCH is having an effect on both growth and function likely by recruiting different proteins. It will be worth exploring which proteins are being activated by MCH to cause the growth effect,” Dr. Kulkarni explains.

A follow-up study has been designed and is currently awaiting funding. It will look at how MCH interacts with glucagon-like peptide 1 (GLP-1), a hormone involved in beta cell growth. An analogue of GLP-1 hormone has already been approved by the FDA for treating type 2 diabetes. The goal is to understand how GLP-1 and MCH can work together to promote beta cell growth.


Related medicine news :

1. The Reason For Loss Of Appetite After Gastric Bypass
2. Stomach Hormone to Aid in Controlling Appetite
3. Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss
4. Brain behind the Brawn: Vital Molecule in the Brain Controls Appetite
5. Appetite Changes, Depression Signal Impulse Control Disorders in Parkinson
6. Study Confirms That Slow Eating Restricts Appetite
7. Estrogen Curbs Appetite: Research
8. Estrogen Curbs Appetite In Same Way as the Hormone Leptin
9. Mitochondrial Protein Maintains Appetite During Fasting
10. Levothyroxine Thyroid Hormone Replacement, Approved for Hypothyroidism
11. Hormone replacement Therapy a headache
Post Your Comments:

(Date:10/13/2015)... GA (PRWEB) , ... October 13, 2015 , ... ... nonprofit promoting the establishment of telemedicine programs in communities throughout Georgia, along with ... announce the collective schedule for their regional telehealth summits for Fall 2015. ...
(Date:10/13/2015)... ... October 13, 2015 , ... According to an ESPN ... orbital fracture when a teammate accidentally elbowed him in the left eye during the ... injury is just one of a series of setbacks, including a knee injury that ...
(Date:10/13/2015)... ... October 13, 2015 , ... In an ... PediaPlex , a Southlake, Texas, child development and pediatric therapy center, is ... educating military families about their options for receiving this kind of care for ...
(Date:10/13/2015)... Niguel, CA (PRWEB) , ... October 13, 2015 ... ... tools, announced the release of a new PDF automation tool to batch ... regulations, and business mandates with 100% document fidelity. , CADConverter eliminates the complexity ...
(Date:10/13/2015)... , ... October 13, 2015 , ... ... winning programs Elder Care Doula Training and End of Life Doula Training. ... a holistic model, physically, spiritually and emotionally. Based on her #1 International ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 8, 2015 Research and Markets ( ... Anti-counterfeit Pharmaceuticals and Cosmetics Packaging - Market Opportunities and ... --> --> ... at a CAGR of 15.7% during 2015-2020 ... technology segment accounted for about 52% share in 2014 ...
(Date:10/12/2015)... the United States . By early next ... --> the United States . By early next ... --> The University of Texas MD Anderson Cancer Center, Elekta ... (1.5 Tesla) MRI-guided linear accelerator in the United States ... in a non-clinical capacity. Royal Philips (NYSE: ...
(Date:10/12/2015)... COSTA MESA, Calif. , Oct. 12, 2015 ... reaffirmed the accreditation of Harbor Compounding Pharmacy in ... accreditation is awarded in recognition of the pharmacy,s ... --> ... --> ...
Breaking Medicine Technology: