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Role Of MicroRNAs In Angiogenesis Researched

According to recent research, MicroRNAs are fine targets for future therapies.Researchers belonging to the University of Pennsylvania School of Veterinary //Medicine have demonstrated how microRNA molecules are responsible for the growth of blood vessels in a human colon cancer model. This process, known as angiogenesis, is a result of the ravenous cancer cells using blood vessels to gorge on a steady supply of nutrients and oxygen.

The findings, which appear in the online version of Nature Genetics, suggest that these MicroRNAs might also be a good target for future therapeutics designed to slow the growth of cancer cells.

"These findings also uncover a new role for a well-known cancer-causing gene called MYC," said Andrei Thomas-Tikhonenko, professor in Penn Vet's Department of Pathobiology. "We have discovered that, within a tumor cell, one of the tasks of MYC is to turn loose a particular set of MicroRNAs, which then becomes responsible for promoting the growth of new blood vessels that nourish the tumor."

MicroRNAs are, as the name implies, short strands of RNA. During the last few years, microRNAs have been found to have a significant role in the process by which genes are translated into proteins. Clusters of microRNA have been "caught" associated with messenger RNA, the intermediary molecule that "instructs" the cell's protein-building machinery. In particular, MicroRNAs help determine the life span of messenger RNA and, therefore, how many copies of a protein can be made from a single messenger RNA molecule.

The Penn researchers discovered the role of microRNAs in angiogenesis while studying what makes MYC unique among other cancer-causing genes, or oncogenes. In particular, they were curious why cells with hyperactive MYC don't accumulate particularly fast in Petri dishes yet grow explosively in animal models for the disease.

"There are obviously no blood vessels in a petri dish, so the angiogen
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