Navigation Links
Role Of Estrogen In Breast-Cancer

Scientists have been wondering how estrogen -dependent breast-cancer cells grow and spread rapidly. Recent research on the above area has revealed that the depletion of estrogen is associated //with loss of regulatory protein.

The scientists report that human breast-cancer cells exposed to estrogen in their laboratory showed a dramatic reduction in numbers of a crucial nuclear receptor corepressor, a protein known as N-CoR . They also found that the anti-estrogen drug tamoxifen, often used in breast-cancer treatments, encouraged N-CoR recovery, a beneficial activity.

Because estrogen has the ability to reduce the levels of N-CoR, it can promote the associated proliferation and progression of breast cancer, as the balance of co-activators and co-repressors involved in normal gene transcription is altered.

The findings may have sweeping implications. For one, the mechanisms at play could explain at least some of the mixed results seen in women using estrogen and progesterone in hormone therapy.

While numbers of N-CoR proteins fell to 20 percent of normal, the level of N-CoR's messenger RNA went untouched. The reduction of N-CoR followed an up regulation of the ubiquitin ligase Siah2, an enzyme that targets certain proteins for degradation.

This "secondary effect" may have broad implications for other important cellular activities. Reductions in N-CoR over time also could promote cancer development in other sites, such as the uterus, and could adversely affect the desired activities of vitamin D, retinoid and thyroid receptors.

The study sheds light on the impact of estrogen on certain cells, as well as how tamoxifen works as an anti-estrogen to facilitate recovery of N-CoR. Understanding more of the mechanisms involved could lead to the development of other related agents that might reduce some of the unwanted side effects of tamoxifen, such as stimulation of the uterus.
'"/>




Page: 1

Related medicine news :

1. Estrogen lowers cancer risk
2. Estrogen Does Not Prevent Recurrent Strokes
3. Herbs With Estrogen Action Aggravate Cancer Risk
4. Osteoarthritis and Estrogen are connected
5. Estrogen Patch is Safer than Pills for Heart
6. Estrogen in Food Reduces Cancer Risk
7. Estrogen Found To Protect the Colon Against Cancer
8. The Side Effects Of Estrogen Therapy
9. The Effects Of Estrogen Therapy
10. A Likely Use For Estrogen Therapy
11. Preventing Colon Cancer With Estrogen
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Role Estrogen Breast Cancer

(Date:8/30/2014)... (PRWEB) August 30, 2014 In today’s world, ... difficult to get. Snoring and sleep apnea (a medical problem ... people and their bed partners of the rest they need ... of the population snores and 20 million people in the ... have been diagnosed and treated; and of those treated, many ...
(Date:8/30/2014)... August 30, 2014 Removecomplaints.net, a well-known ... industry, has announced to offer guarantee of results with ... offer this guarantee because of its tremendous track record. ... clients from all over the world and received recommendation ... job. , On being asked about the announcement, ...
(Date:8/30/2014)... 2014 When a prominent bank reveals a ... on Wednesday, August 27th, when news began surfacing about the ... & Co and at least one other bank. But ... investigating attacks on seven prominent banks , everyone starts thinking ... and the buzz quickly goes viral. Bloomberg followed up ...
(Date:8/30/2014)... Miami, FL (PRWEB) August 30, 2014 Zensah®, ... new Camo Compression Leg Sleeve . The camo sleeves ... Compression Leg Sleeve collection. The camo line includes classic ... purple and magenta. , Known as tibial stress syndrome, ... side of the lower leg. Swollen and irritated muscles, stress ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 Celebrating ... observance that educates Americans about the fact that ... recovery, from alcohol and drug addiction and mental ... join with treatment providers, prevention programs and other ... individuals, families, workplaces and neighborhoods. The rallying ...
Breaking Medicine News(10 mins):Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Removecomplaints.net Announces Guaranteed Complaints Removal Services 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 3Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 4Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 5Health News:Camo Compression Leg Sleeves Provide Shin Splint Relief for Runners 2Health News:September is National Recovery Month: What the Connecticut Community for Addiction Recovery (CCAR) Wants You to Know 2Health News:September is National Recovery Month: What the Connecticut Community for Addiction Recovery (CCAR) Wants You to Know 3
... finds that almost half of the U.S. population possesses a ... of developing diabetes. // ,Diabetes is one of the ... many other complications. Genes are one among the many factors ... assistant professor of nutrition and dietetics at Doisy College of ...
... healthy eating habits, teens in middle adolescence are eating ... study reveals.// And the situation only worsens as teens ... important for the prevention of future chronic disease,” said ... it’s important to know whether intakes of teens are ...
... Louis University researcher confirms findings that about half of the ... them to metabolize food// differently, putting them at greater risk ... professor of nutrition and dietetics at Doisy College of Health ... version of a gene called FABP2, which is involved in ...
... the University of California, San Diego has found what ... promote cancer. The findings// may provide a new approach ... that what scientists thought were two distinct processes in ... dangers such as invading organisms—are actually linked. The researchers, ...
... Center-led study has shown conclusively that a neuropeptide, melanin ... for its role in// increasing appetite in people, plays ... and the secretion of insulin. This finding has the ... diabetes that stimulate the production of insulin-producing beta cells ...
... physicians predicts early risk of stroke following a serious condition ... a "mini-stroke," according to a study. ,About ... and about 70,000 in the United Kingdom. A TIA is ... oxygen supply to part of the brain that can cause ...
Cached Medicine News:Health News:Today’s Teens Slacking on Fruit, Veggie Intak 2Health News:Molecular Link Between Inflammation and Cancer Discovered 2Health News:Molecular Link Between Inflammation and Cancer Discovered 3Health News:Role of Appetite Hormone MCH in Insulin Production Revealed 2Health News:New Tool Improves Prediction of Stroke Risk 2
(Date:8/29/2014)... 2014 /PRNewswire-iReach/ -- SAM Medical Products Implements Voluntary ... SAM Junctional Tourniquet.  Photo - ... Products announced today that it has begun notifying ... potential issue with a clip used to secure ... of the SAM Junctional Tourniquet (SJT).  The company ...
(Date:8/29/2014)... PARK, Calif. , Aug. 29, 2014 ... Medical as CEO and member of the Board of ... decades of medical device development and commercialization experience, including ... field. Mr. Engelson previously served as a Partner of ... as President and CEO of two Foundry start-ups. Mr. ...
(Date:8/29/2014)... , Aug. 29, 2014 Research and ... "Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014" ... conventional methods developed to prevent and eradicate the prevalence ... These methods are confined to low specificity, safety and ... to look for a better solution. It has been ...
Breaking Medicine Technology:SAM Medical Products Implements Voluntary Recall of its Accessory (Axilla) Strap for the SAM Junctional Tourniquet. 2Medina Medical Announces Erik T. Engelson Joins as Chief Executive Officer 2Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2
... from EAP in 2007, RICHMOND, Va., Jan. ... follow-on biologics and biopharmaceuticals, today,provided an update on ... the treatment of Amyotrophic Lateral Sclerosis (ALS). Since ... physicians and approximately 70 subjects,have been enrolled into ...
... Kind in US, Finds Allergy Immunotherapy ... Beneficial Even When Treatment Not Completed, MOSS ... health economics and outcomes research, today announced,findings of a ... benefits to children and significantly reduces health,care costs, even ...
Cached Medicine Technology:Insmed Provides Update on IPLEX(TM) Expanded Access Program in Italy for the Treatment of Amyotrophic Lateral Sclerosis 2Insmed Provides Update on IPLEX(TM) Expanded Access Program in Italy for the Treatment of Amyotrophic Lateral Sclerosis 3Study Says Allergy Shots Help Children, Reduce Health Care Costs 2Study Says Allergy Shots Help Children, Reduce Health Care Costs 3
Portal accessory instrument set. Set also includes a package of 8 mm Guide Wires (.15 cm x 38 cm), and Sterilization Tray....
The Small Oval Cannula System is designed to be the smallest oval cannula system currently available, and is utilized with the Caspari Suture Punch System. Disposable seals are available with this sy...
...
Suture retriever forceps...
Medicine Products: