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Risks/Benefits of Osteoporosis Drug Use in Postmenopausal Women

The drug may help prevent breast cancer and vertebral fractures, but raise the risk of blood clots and fatal strokes.//

A study in the July 13 issue of the New England Journal of Medicine, reporting the results of a 5-1/2 year-long trial of more than 10,000 postmenopausal women with a history of heart disease or at high risk for heart disease, shows that patients given raloxifene therapy had a reduced incidence of vertebral fractures and breast cancer, but an increased incidence of blood clots and fatal strokes. The multi-site international study was headed by Elizabeth Barrett-Connor, M.D., Professor of Family and Preventive Medicine at the University of California, San Diego (UCSD) School of Medicine.

The study showed mixed results. On the positive side, raloxifene therapy reduced invasive breast cancer by 44 percent with 1.2 fewer cases per 1000 women treated for one year. Raloxifene has anti-estrogenic effects in the breast, inhibiting the growth of estrogen-stimulated breast cancer. It also reduced painful vertebral fractures by 35% with 1.3 fewer cases per 1000 women.

On the other hand, use of raloxifene was shown to raise the risk of blood clots by 44%, or 1.2 cases per 1000 women treated for one year. Additionally, 59 of the 5,044 raloxifene users had fatal strokes, compared to only 39 of the half on placebo, an absolute increase of 0.7 cases per 1000 women treated for one year, or a 49 percent greater risk of stroke-related death – though there was no significant difference in the total number of stroke episodes.

“The breast cancer prevention benefits may not justify the risks of taking raloxifene for some patients, especially those already prone to heart problems, because of the risk related to other diseases,” said Barrett-Connor, who added that women should talk about risks with their doctors.

Doctors had thought that the drug might help prevent heart problems, because it lowers cholesterol leve
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