Navigation Links
Risks/Benefits of Osteoporosis Drug Use in Postmenopausal Women

The drug may help prevent breast cancer and vertebral fractures, but raise the risk of blood clots and fatal strokes.//

A study in the July 13 issue of the New England Journal of Medicine, reporting the results of a 5-1/2 year-long trial of more than 10,000 postmenopausal women with a history of heart disease or at high risk for heart disease, shows that patients given raloxifene therapy had a reduced incidence of vertebral fractures and breast cancer, but an increased incidence of blood clots and fatal strokes. The multi-site international study was headed by Elizabeth Barrett-Connor, M.D., Professor of Family and Preventive Medicine at the University of California, San Diego (UCSD) School of Medicine.

The study showed mixed results. On the positive side, raloxifene therapy reduced invasive breast cancer by 44 percent with 1.2 fewer cases per 1000 women treated for one year. Raloxifene has anti-estrogenic effects in the breast, inhibiting the growth of estrogen-stimulated breast cancer. It also reduced painful vertebral fractures by 35% with 1.3 fewer cases per 1000 women.

On the other hand, use of raloxifene was shown to raise the risk of blood clots by 44%, or 1.2 cases per 1000 women treated for one year. Additionally, 59 of the 5,044 raloxifene users had fatal strokes, compared to only 39 of the half on placebo, an absolute increase of 0.7 cases per 1000 women treated for one year, or a 49 percent greater risk of stroke-related death – though there was no significant difference in the total number of stroke episodes.

“The breast cancer prevention benefits may not justify the risks of taking raloxifene for some patients, especially those already prone to heart problems, because of the risk related to other diseases,” said Barrett-Connor, who added that women should talk about risks with their doctors.

Doctors had thought that the drug might help prevent heart problems, because it lowers cholesterol leve ls. However, the study showed that raloxifene therapy did not significantly reduce the risk of coronary events such as heart attack, hospitalization or death in the clinical trial group assigned to raloxifene therapy, made up of women with previous established or proven risk of heart disease.

Raloxifene is a non-steroidal selective estrogen-receptor modulator (SERM) produced by Eli Lilly. The drug is sold as Evista for preventing and treating osteoporosis, and has also been tested by doctors as an alternative to tamoxifen for preventing breast cancer in a previous trial.

The Raloxifene Use for the Heart (RUTH) trial began in 1998 to determine the effects of the drug on clinical coronary events in women with or at increased risk for coronary heart disease. Eligible participants were women age 55 years or older, who were at least one year postmenopausal, and had established or risk factors for heart disease such as clogged arteries, high blood pressure or cholesterol level, smoking or diabetes. Women at 177 sites in 26 countries were randomly assigned to treatment or placebo.

After an average of five years, the RUTH study showed that deaths and major heart problems were about the same in both the group receiving raloxifene and those taking a placebo. Raloxifene users experienced one-third fewer cases of breast cancer and about half the number of invasive breast cancers.

(Source: Newswise
'"/>




Related medicine news :

1. New treatment for Osteoporosis
2. Osteoporosis in men
3. Osteoporosis Drugs: right time to take-off
4. Fluoride Found Effective in Osteoporosis
5. Mutation connected to Osteoporosis
6. Osteoporosis associated with Childhood Cancer
7. A treatment for Osteoporosis
8. Osteoporosis could be caused by irregular periods
9. Back exercises reduces Osteoporosis
10. Osteoporosis and kidney stones gene marker identified
11. The Answer To Prevent Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... ... 05, 2016 , ... Freed-Hardeman University President Joe A. Wiley ... joint enrollment and degree completion agreement. The agreement, which begins with the ... FHU|Dickson. , The agreement allows students to be jointly admitted to both ...
(Date:2/5/2016)... ... 05, 2016 , ... The American public tends to feel uncomfortable about drinking ... regular municipal or well water. The recent experience with lead contaminated water in Flint, ... long way toward increasing public acceptance of recycled waste water as drinking water. ...
(Date:2/5/2016)... ... , ... At its annual meeting held last week, the American Parkinson Disease ... of Directors. Mr. McDermott succeeds former APDA Chairman, Fred Greene. , "We are pleased ... APDA President and CEO. “Pat has tirelessly served APDA since 2001 when he was ...
(Date:2/5/2016)... IL (PRWEB) , ... February 05, 2016 , ... In ... disguised form as a dream. A hallmark feature of patients with eating disorders is ... needs. The eating disorder behaviors and obsessions are regarded as maladaptive means for coping ...
(Date:2/5/2016)... ... February 05, 2016 , ... KICVentures ( http://www.kicventures.com ... Development event in New York City on Thursday, January 21, 2016. Kingsley ... Mediacom, (both alumnus of the varsity Columbia soccer program) spoke at the event, ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... HARROGATE, England , February 5, 2016 ... --> Today, VoicePower Ltd - The Speech Recognition People, ... has been deployed to improve patient care, reduce turnaround times and ... ,- Wirral CCG ,- VoicePower client since 2013 Challenge: ... Challenge: --> - Six doctors ,- Wirral ...
(Date:2/4/2016)...  Edwards Lifesciences Corporation (NYSE: EW ), the ... and critical care monitoring, announced today that it has ... Morgan Stanley & Co. LLC to repurchase $325 million ... the Company,s previously authorized program to repurchase up to ... --> --> Under the ...
(Date:2/4/2016)... FOSTER CITY, Calif. , Feb. 4, 2016 ... (the "Company") today announced it has entered into ... and Exchange Commission (SEC) fully resolving the SEC,s ... Practices Act (FCPA).  Under the terms of the ... total of $12.8 million, including disgorgement, pre-judgment interest ...
Breaking Medicine Technology: