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Risk Of Heart Attack Increased By Gout

iuretics and alcohol. Modest yet statistically significant elevations of blood pressure, age, blood glucose and body mass index were observed in the gout group. Subjects in the group with gout were less likely to be current smokers than were those in the group without gout.

During the course of the study, 1,108 events of acute MI occurred in the group with gout (10.5 percent) and 990 events in the group without gout (8.43 percent). Of the 1,108 MIs, 246 were fatal.

The study also found a relationship between gout and the risk of acute MI to be present among nonusers of alcohol, diuretics or aspirin and among those who did not have metabolic syndrome, diabetes mellitus or obesity.

"The absolute magnitude of the relative risk for the presence of gout was not high. Yet, the odds ratio associated with gout was relatively high compared to other risk factors in this study," Dr. Krishnan said. "For acute MI to occur, an environment that promotes atherogenesis and thrombogenesis is needed. Hyperuricemia is well known to be an independent risk factor for atherosclerotic diseases in general and since chronic hyperuricemia is strongly associated with gout, it is not very surprising that an independent coronary risk for the presence of both hyperuricemia and gout was observed."

Contact: Frank Raczkiewicz
RaczkiewiczFA@upmc.edu
412-647-3555
University of Pittsburgh Medical Center
Source: Eurekalert

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