Navigation Links
Risk Of Heart Attack Increased By Gout

Gout increases the risk of suffering a heart attack, according to new research from University of Pittsburgh School of Medicine.The study is published// in the August edition of the journal Arthritis & Rheumatism and the full article is available on line at
http://www3.interscience.wiley.com/
cgibin/jhome/76509746 This is the first time that researchers have demonstrated that people having no risk of coronary heart disease could be at risk for heart attack due to gout.

Gout is a metabolic disease marked by acute arthritis and inflammation of the joints, usually beginning in the knee or foot. It is caused by hyperuricemia, a build up of uric acid in blood. When chronic or severe hyperuricemia leads to urate crystals within joints, it results in an inflammatory response that manifests as gouty arthritis.

"Our study confirms that gouty arthritis is an independent risk factor for myocardial infarction (MI) or heart attack. Until now this relationship has not been explained by well-known links to renal function, metabolic syndrome, diuretic use and the traditional cardiovascular risk factors," said Eswar Krishnan, M.D., assistant professor of medicine at the University of Pittsburgh School of Medicine, division of rheumatology, and principal author of the study.

The prospective study examined data from 12,866 men who were enrolled for a mean of 6.5 years in the Multiple Risk Factor Intervention Trial (MRFIT), a randomized primary cardiovascular disease prevention trial conducted and supported by the National Heart, Lung and Blood Institute.

There were 5,337 men with hyperuricemia at the beginning of the study. Over the study period, 1,123 individuals developed gouty arthritis. There was no statistically significant difference between the groups with regard to cholesterol levels, aspirin use, family history of acute MI, or diabetes mellitus. However, the group with gout was significantly more likely to have used d iuretics and alcohol. Modest yet statistically significant elevations of blood pressure, age, blood glucose and body mass index were observed in the gout group. Subjects in the group with gout were less likely to be current smokers than were those in the group without gout.

During the course of the study, 1,108 events of acute MI occurred in the group with gout (10.5 percent) and 990 events in the group without gout (8.43 percent). Of the 1,108 MIs, 246 were fatal.

The study also found a relationship between gout and the risk of acute MI to be present among nonusers of alcohol, diuretics or aspirin and among those who did not have metabolic syndrome, diabetes mellitus or obesity.

"The absolute magnitude of the relative risk for the presence of gout was not high. Yet, the odds ratio associated with gout was relatively high compared to other risk factors in this study," Dr. Krishnan said. "For acute MI to occur, an environment that promotes atherogenesis and thrombogenesis is needed. Hyperuricemia is well known to be an independent risk factor for atherosclerotic diseases in general and since chronic hyperuricemia is strongly associated with gout, it is not very surprising that an independent coronary risk for the presence of both hyperuricemia and gout was observed."

Contact: Frank Raczkiewicz
RaczkiewiczFA@upmc.edu
412-647-3555
University of Pittsburgh Medical Center
Source: Eurekalert

'"/>




Related medicine news :

1. One in Three Heart Attack Patients Have No Chest Pains
2. Epileptic Seizures Can Be Due to Heart Problem
3. Bypass Heart Surgery Performed Without General Anesthesia
4. New CPR Guidelines issued by Heart Association
5. White Cells Count Can Predict Heart Attack Death Risk
6. Vitamins-The answer to Heart Disease?
7. Fight Heart disease and Pain with Meditation
8. Heart disease in the newborn is related to maternal malnutrition
9. New drug to treat Heart Attack and damaged tissue
10. Heart disease threat starts early in life for Diabetics
11. Mechanical Heart
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2017)... ... August 21, 2017 , ... ... two plastic surgery fellows for academic year 2017-2018, Christina M. Busuito, M.D. and ... successfully completed residency in Plastic and Reconstructive Surgery. The candidate will have ...
(Date:8/21/2017)... ... ... FCPX LUT Monochromatic Volume 2 is an all-new Look-Up Table color-grading pack ... to footage. A LUT is a Lookup Table that contains a mathematical formula for ... by the table. This pack comes with 60 different monochromatic CUBE LUT files. , ...
(Date:8/21/2017)... ... August 21, 2017 , ... SportsEngine, Inc. , ... Official Technology Partner of North Country Region Volleyball and will power registration, scheduling, ... along with providing sport management software to their member clubs. , ...
(Date:8/21/2017)... (PRWEB) , ... August 21, 2017 , ... Five chefs ... and awareness for Alzheimer’s Family Center. , Guests will be able to vote ... Beach Plaza, Braised Lamb Shank with Fennel Dill Salad, Feta Cheese Sauce & Garlic ...
(Date:8/21/2017)... ... August 21, 2017 , ... Marathon running has surged ... country. , Outdoor running increases exposure to ultraviolet radiation, a carcinogen that promotes ... melanoma, and only half may be adequately protecting themselves with proper clothing and ...
Breaking Medicine News(10 mins):
(Date:8/18/2017)... , Aug. 18, 2017  Nortis today announced the awarding of a $688K ... for the third year of a Small Business Innovation ... Institute of Neurological Disorders and Stroke (NINDS).?  ... Nortis ParVivo Chip ... ...
(Date:8/17/2017)... , Aug. 17, 2017 MJAC2017 , ... – Canna Broadcast Media, today reveals its leading lineup. ... International Inc., a global cannabis innovator specializing in the development ... of the conference. MassRoots, Rambridge™ and The Green Organic Dutchman ... Inc. and Namaste Vapes™ as silver sponsors. ...
(Date:8/17/2017)... 2017 DarioHealth Corp. (NASDAQ: DRIO), a ... and big data solutions, announced today that it ... non-U.S. investors for the sale of shares of ... Company,s newly designated Series B Convertible Preferred Stock ... to conduct a closing with respect to the ...
Breaking Medicine Technology: