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Risk Of Colorectal Polyps Recurrence Can Be Controlled By Rofecoxib

A new study shows that COX-2 inhibitor 'Rofecoxib' might be effective in controlling the recurrence of colorectal cancer. //

According to a new, 'A Randomized Trial of Rofecoxib for the Chemoprevention of Colorectal Adenomas,' being published in Gastroenterology, the journal for the members of the American Gastroenterological Association (AGA), cyclooxygenase-2 (COX-2) inhibitor Rofecoxib cuts the risk of colorectal adenomas. The findings of the study though initially was to be published in December, was released online in August because of the clinical importance of the findings. John Baron, MD, lead author of the paper and a professor at Dartmouth Medical School, has been studying chemoprevention of colorectal cancer for more than twenty years. 'These are exciting findings,' he said. 'They show once again the potential for non-steroidal anti-inflammatory drugs, or NSAIDs, to interfere with the development of cancer in the colon and rectum.'

Extensive data have suggested previously that aspirin and non-selective nonsteroidal anti-inflammatory drugs (NSAIDs) could reduce colon cancer risk. This study now demonstrates such an effect for a selective COX-2 inhibitor in a placebo-controlled randomized study. While previous randomized studies have shown that COX-2 inhibitors can lower the risk of adenoma in patients with a rare genetic syndrome called familial adenomatous polyposis (FAP), the effect in the broad population of people at risk for colorectal cancer has not been previously demonstrated. More commonly referred to as 'polyps,' adenomas are benign tumors that are precursors to colon cancer, and are commonly found in older adults in the United States and worldwide.

The APPROVe (Adenomatous Polyp Prevention on Vioxx) study was a randomized, placebo-controlled, double blind trial funded by Merck Research Laboratories. Study results showed that patients taking rofecoxib had a lower recurrence rate of adenomas than thos
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