Navigation Links
Risk Factors for Rheumatoid Arthritis

A new study sheds light on the role of environmental and genetic risk factors in the development of rheumatoid arthritis (RA). A team of researchers in Sweden have identified smoking, a low formal level of education and certain metabolic indicators as important risk factors in the development of RA.

These findings represent a significant step towards better understanding of the risk factors for RA and may contribute to improved future prevention and treatment of this debilitating disease.

The first study showed that smoking (odds ratio 1.77; 95% confidence interval 1.13 to 2.78) and a low level of formal education, such as elementary school education only versus university degree status (odds ratio 2.46 confidence interval 1.20 to 5.02), may independently increase the risk of developing RA.

The second study similarly highlights the link between of smoking and RA but, contrary to previously noted relationships between RA with active inflammation and impaired glucose tolerance, observes better glucose tolerance as a predictor of RA.

In the multivariate model, a lower glucose level at 120 minutes after an oral glucose tolerance test (odds ratio 1.19 per mmol/L; confidence interval 1.04 to 1.35) and smoking (odds ratio 1.64; confidence interval 1.08 to 2.48) were both found to be independent predictors of RA. Thus the authors suggest that factors such as diet and genetics influencing metabolism may play an important part in RA development.

Dr Ulf Bergstrom from the Malm University Hospital, Sweden, lead investigator on both studies said, The determinants for developing RA in any population are clearly complex and often unrelated. These studies help us to add more pieces to the giant jigsaw of risk factors for one of the most common autoimmune diseases, affecting approximately 1% of adults worldwide.

We hope these findings will contribute to better understanding of future RA prevention and treatment. Whilst the glucose tolerance findings contrast with previous studies linking impaired tolerance to established RA, they suggest that other mechanisms may be important years before RA onset. Our results will pave the way for future debate and research to pinpoint its definitive causes.

research to pinpoint its definitive causes.

The two studies involved people enrolled in the Malmo Diet and Cancer Study (MDCS) (n=30,447) between 1991 and 1996 and a Preventive Medicine Program (PMP) (n=33,346) between 1974 and 1992.

Investigators examined lifestyle factors using a self-administered questionnaire and glucose tolerance and lipids readings were taken by health professionals. Individuals who developed RA after participation in the health surveys were compared to controls without RA from the PMP and MDCS, matched for age, sex and year of screening.


Related medicine news :

1. Risk Factors for vision problems in Diabetes
2. Age-Related Macular Degeneration - Risk Factors
3. Factors That Might Increase The Risk Of Schizophrenia
4. Evaluating The Risk Factors Of Osteoporosis
5. Risk Factors For Stroke Studied
6. Analyzing The Risk Factors For Diabetic Neuropathy
7. Heart Disease Risk Factors Found To Increase Risk of Dementia In Old Age
8. Environmental Factors Found To Have An Impact On The Sex of A Child
9. Environmental Factors Found To Have An Impact On The Sex of A Child
10. Prostate Cancer Test Is Influenced By Age and Nutrition Factors
11. Youth Smoking Sparked By Multiple Factors: Study
Post Your Comments:

(Date:11/24/2015)... , ... November 24, 2015 , ... ... the organization will waive paid entry and parking fees at several of their ... Monument Mountain in Great Barrington in support of REI’s Black Friday #OptOutside Campaign. ...
(Date:11/24/2015)... ... November 24, 2015 , ... Cancer patients, survivors, caregivers, ... at a live taping of the next CURE Connections® video series ... Cancers 2015 Symposium at Georgetown University Hotel & Conference Center in Washington, D.C. ...
(Date:11/24/2015)... ... 2015 , ... With Thanksgiving right around the corner, holiday travel season is ... your family and vehicle. , According to the National Highway Traffic Safety Administration, 301 ... sharing the following safety tips from the NHTSA: , ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... Cleveland University-Kansas City (CU-KC), in Overland Park, Kansas. Benson, a fifth-trimester ... University President Carl S. Cleveland III on October 16. , “Katie is very ...
(Date:11/24/2015)... ... 24, 2015 , ... Bibliomotion is thrilled to announce the launch ... and Diversity by Nancy M. Schlichting, Chief Executive Officer of Henry Ford ... address the needs of patients and their families, shaped my desire to improve the ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Avery Biomedical Devices (ABD), manufacturer of the ... appointment of Anders Jonzon , MD; Ph.D. as ... Dr. Jonzon is a Physiologist and consultant ... University, Uppsala and Children,s Hospital, Karolinska, Stockholm, ... at the Cardiovascular Institute (UCSF). His research has covered ...
(Date:11/24/2015)... BERN, Switzerland , November 24, 2015 ... Engineering Research of the University of Bern ... and Clinical Nutrition of the Bern University Hospital "Inselspital" ... collaboration to develop a novel generation artificial pancreas. Combining ... of insulin for diabetic patients with the unequalled accuracy ...
(Date:11/24/2015)... 24, 2015 Diplomat Pharmacy, Inc. (NYSE: DPLO) announced ... Clinical Services, Education and Human Resources will be presenting in ... Drugs: Health Plan Strategies for a Dynamic Market" on Dec. ... , a consultant with the Cambridge Advisory Group, where she ... The webinar will discuss the rapid growth of ...
Breaking Medicine Technology: