Navigation Links
Risk Factors for Rheumatoid Arthritis

A new study sheds light on the role of environmental and genetic risk factors in the development of rheumatoid arthritis (RA). A team of researchers in Sweden have identified smoking, a low formal level of education and certain metabolic indicators as important risk factors in the development of RA.

These findings represent a significant step towards better understanding of the risk factors for RA and may contribute to improved future prevention and treatment of this debilitating disease.

The first study showed that smoking (odds ratio 1.77; 95% confidence interval 1.13 to 2.78) and a low level of formal education, such as elementary school education only versus university degree status (odds ratio 2.46 confidence interval 1.20 to 5.02), may independently increase the risk of developing RA.

The second study similarly highlights the link between of smoking and RA but, contrary to previously noted relationships between RA with active inflammation and impaired glucose tolerance, observes better glucose tolerance as a predictor of RA.

In the multivariate model, a lower glucose level at 120 minutes after an oral glucose tolerance test (odds ratio 1.19 per mmol/L; confidence interval 1.04 to 1.35) and smoking (odds ratio 1.64; confidence interval 1.08 to 2.48) were both found to be independent predictors of RA. Thus the authors suggest that factors such as diet and genetics influencing metabolism may play an important part in RA development.

Dr Ulf Bergstrom from the Malm University Hospital, Sweden, lead investigator on both studies said, The determinants for developing RA in any population are clearly complex and often unrelated. These studies help us to add more pieces to the giant jigsaw of risk factors for one of the most common autoimmune diseases, affecting approximately 1% of adults worldwide.

We hope these findings will contribute to better understanding of future RA prevention and treatment. Whilst the glucose tolerance findings contrast with previous studies linking impaired tolerance to established RA, they suggest that other mechanisms may be important years before RA onset. Our results will pave the way for future debate and research to pinpoint its definitive causes.

research to pinpoint its definitive causes.

The two studies involved people enrolled in the Malmo Diet and Cancer Study (MDCS) (n=30,447) between 1991 and 1996 and a Preventive Medicine Program (PMP) (n=33,346) between 1974 and 1992.

Investigators examined lifestyle factors using a self-administered questionnaire and glucose tolerance and lipids readings were taken by health professionals. Individuals who developed RA after participation in the health surveys were compared to controls without RA from the PMP and MDCS, matched for age, sex and year of screening.


'"/>




Related medicine news :

1. Risk Factors for vision problems in Diabetes
2. Age-Related Macular Degeneration - Risk Factors
3. Factors That Might Increase The Risk Of Schizophrenia
4. Evaluating The Risk Factors Of Osteoporosis
5. Risk Factors For Stroke Studied
6. Analyzing The Risk Factors For Diabetic Neuropathy
7. Heart Disease Risk Factors Found To Increase Risk of Dementia In Old Age
8. Environmental Factors Found To Have An Impact On The Sex of A Child
9. Environmental Factors Found To Have An Impact On The Sex of A Child
10. Prostate Cancer Test Is Influenced By Age and Nutrition Factors
11. Youth Smoking Sparked By Multiple Factors: Study
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2017)... ... May 20, 2017 , ... ... designs created specifically for use in Final Cut Pro X. The business-oriented elements ... productions. Pixel Film Studios’ ProParagraph Corporate will deliver a professional and distinguished look ...
(Date:5/21/2017)... ... ... Florida Pain Relief Group, a division of Physician Partners of America (PPOA), is ... Melbourne, on Monday, May 22. Initially the clinic will be supervised by Physician Partners ... 23 pain management clinics in Florida and the Dallas-Fort Worth, Texas metro area, and ...
(Date:5/21/2017)... Houston,Texas (PRWEB) , ... May 21, 2017 , ... ... but if it's been longer than six months since you've seen a dentist, ... dentist twice per year and getting x-rays once per year. , Dental checkups ...
(Date:5/19/2017)... ... May 19, 2017 , ... ... in an upcoming episode of Innovations with Ed Begley, Jr., airing fourth quarter ... the distributor of a clean, organic dietary supplement made from naturally occurring ingredients. ...
(Date:5/19/2017)... CA (PRWEB) , ... May 19, 2017 , ... The ... consulting to families and entrepreneurs throughout the California Central Valley, is announcing a joint ... of raising community support for a local kid’s camp event. , The Boys and ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... May 4, 2017  Fortuna Fix Inc. (" Fortuna ... the first to eliminate the need for embryonic and fetal ... treat neurodegenerative diseases. Fortuna announced today ... Michael Fehlings , MD, PhD; Father Kevin FitzGerald ... MPH; and Professor James Giordano , PhD. ...
(Date:5/4/2017)... 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global ... solutions, today announced that it is teaming up with ... Limited to lower diabetes healthcare costs in ... which is available throughout all provinces and territories in ... eligible for additional savings when shopping for Dario supplies ...
(Date:5/3/2017)... 2017  Kalorama Information notes that transplant diagnostics ... year and this is projected to continue to ... (HSCT) or bone marrow transplants require histocompatibility between ... for this task. This according to a new ... The various PCR-based methodologies, Sanger sequencing and NGS ...
Breaking Medicine Technology: