Navigation Links
Rhode Island Biotechnology Company Develops Tularemia Vaccine

EpiVax, Inc, a leader in genome-derived vaccines, announced today that it has developed a promising tularemia vaccine // candidate (TuliVaxTM) that confers protective immunity. Francisella tularensis is a bacterium considered to be one of the most dangerous potential bioterror agents.

This vaccine project was funded by a BioDefense Small Business Innovation Research (SBIR) grant by the National Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institutes of Health (NIH). The animal studies, conducted at Rhode Island Hospital, showed that TuliVaxTM protected mice from lethal bacterial challenge.

“Our unique ability to develop safe and effective vaccines by screening whole genomes for candidate vaccine components with computer algorithms is at the core of this research effort,” said Anne De Groot, M.D., President and CEO of EpiVax. “These study results highlight the ability of our computer-aided vaccine design (VaccineCAD) approach to create effective and innovative vaccines at an accelerated pace”.

Tularemia is rare but does occur naturally; the most lethal pulmonary form is more common in Martha’s Vineyard than in most other places in the world. EpiVax collaborated with Martha’s Vineyard Hospital to obtain bloods from people with previous tularemia infection; 95% of the study participants demonstrated robust responses to the TuliVaxTM components.

Mice with “humanized” immune systems were used by Rhode Island Hospital collaborator Stephen Gregory PhD, Associate Professor of Medicine, Department of Medicine, Rhode Island Hospital and Brown Medical School, to assess the ability of the vaccine to protect against a lethal dose of F. tularensis. Although all of the mice that received a placebo vaccine died when exposed to tularemia, the majority of the mice that received TuliVaxTM survived.

The development of a safe and effective tularemia vaccine has proven elusive; the live vaccine str ain (LVS) of tularensis was the major tularemia vaccine under study for many years. Although it conferred partial protection, federal funding to license LVS has been cancelled due to safety and manufacturing concerns1.

“There is an urgent need for a safe, effective tularemia vaccine to address both natural infections and potential biothreats. TuliVax is likely to be safe because it is composed of small synthetic parts, not the live bacterium”, says Dr. Gregory. “Preliminary results in mice are encouraging; additional experiments are required to provide the data needed for TuliVax to progress to human clinical trials.”



Source-Bio-Bio Technoogy
SRI
'"/>




Related medicine news :

1. Rhode Island legalizes use and possession of Marijuana
2. Meningitis Scare Keeps Children At Home In Rhode Island
3. Rhode Island legalizes use and possession of Marijuana
4. Chikungunya Epidemic On French Island Claims 52 lives
5. French Minister To Visit La Reunion Island To Monitor Chikungunya Epidemic
6. Phoenix Islands To Be Protected Under Global Conservation Map
7. Assams Floating Hospital To Render Medical Services To Islanders
8. Reports Of A HIV Break Out Scare People Of A Holiday Island
9. King Island Water Certified Potable
10. E. coli causes havoc in Fire Island
11. Meningitis Scare Keeps Children At Home In Rhode Island
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/24/2017)... ... July 24, 2017 , ... Engineers at the University ... it produces the same kind of electrical energy that the body uses. , ... moving electrons. This flow of electrons out of the battery is generated by moving ...
(Date:7/24/2017)... ... 24, 2017 , ... Cosmetic Town, an online plastic surgery information community, announces ... on a daily basis. , The new video series will feature board-certified doctors ... their practices. , When asked about the new video series, the senior editor ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... in scholarship awards to be awarded annually to and divided between two full-time ... in bringing awareness to Amazonian plant medicine. To apply for the scholarship, students ...
(Date:7/24/2017)... ... 2017 , ... The Topricin Companies, formerly Topical Biomedics, is ... natural, after-burn skin care product, Topricin After Burn Cream. , Overexposure ... conditions, including cancer. In the short term, overexposure to sun, wind and ...
(Date:7/24/2017)... ... , ... Anyone who uses scales know they have limits; a small kitchen ... same scale to dispense medication. The first example is an issue of capacity, while ... is important to have the right balance for the process. METTLER TOLEDO’s new white ...
Breaking Medicine News(10 mins):
(Date:7/20/2017)... -- Prime Therapeutics LLC (Prime) released this statement from its Chief ... for Clinical and Economic Review,s (ICER) public meeting ... of abuse-deterrent formulations (ADF) of opioids. Prime was the sole ... "The ICER data ... use of abuse-deterrent formulations (ADF) in opioids in terms of ...
(Date:7/14/2017)... It should come as no surprise to anyone that ... of a crippling opioid epidemic. According to the Center ... deaths from opiate-based medications has quadrupled, Says, Dr. David ... 2001 to 2015". During this time, the prescription rate for ... a compelling link between prescription and eventual addiction. The problem ...
(Date:7/12/2017)... , July 12, 2017  Eli Lilly and Company (NYSE: ... with generic companies to resolve pending patent litigation in the ... Virginia regarding the Cialis ® (tadalafil) unit ... April 26, 2020. As part of the agreement, Cialis exclusivity ... 27, 2018. "The unit dose patent for Cialis ...
Breaking Medicine Technology: