Navigation Links
Revolutionary Eye Cancer Treatment

loped by Roche Pharmaceuticals (Nutley, N.J.) for a similar use against a related target called MDM2 in adult cancer cells.

The success in knocking out MDMX with nutlin-3 represents the first example of local delivery of a targeted chemotherapy drug for any childhood cancer, Dyer said.

Targeted therapy uses a customized drug to disable a specific molecule inside a growing cancer cell; local delivery is the placement of a drug at the site of disease, rather than systemic treatment. In systemic treatment, such as chemotherapy, a drug is infused into the body through a vein and then circulates, often causing toxic side effects that are especially challenging in children.

After demonstrating that nutlin-3 is effective when applied directly to the eye, the St. Jude team modified the treatment by combining this molecule with topotecan, a drug also being investigated in the treatment of retinoblastoma. Local delivery of this two-drug targeted treatment was even more effective, reducing tumor size significantly more than the most effective known combination of standard chemotherapy drugs.

"The findings suggest that this treatment not only could offer children with retinoblastoma more effective and less-toxic treatment," Dyer said. "It could also increase the chance that their vision can be preserved by eliminating the tumor and preventing its spread from the eye to the rest of the body."

The discovery that blocking MDMX releases the apoptosis response in retinoblastoma has important implications for certain forms of adult cancers as well. "Some forms of breast, lung, prostate and colon cancer are caused by abnormally large quantities of MDMX in the cells," Dyer explained. "So knocking out MDMX in those cancers might also dramatically reduce tumor size. And administering the drug directly to the site of the tumor could make the treatment especially effective while avoiding the toxicity caused by systemic exposure." T
'"/>




Page: 1 2 3 4

Related medicine news :

1. Revolutionary Simple Pregnancy Blood Test Can Save Both Mother And Child
2. Revolutionary Pill Cuts Risk of Breast Cancer
3. A Revolutionary New Treatment For Cancer Available In Australia
4. New Revolutionary Drug Could Stop the Spread of HIV
5. Revolutionary New Treatment Plan Developed For Treatment Of Unexplained Symptoms
6. Revolutionary Net To Control Malaria
7. Revolutionary Net To Control Malaria
8. Revolutionary Pill Promises Relief for Hay Fever Sufferers
9. Fibroids unlikely to Turn Cancerous
10. Virus Level could Predict Cervical Cancer Risk
11. Cancer Doctors Okays Controversial Prostate Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Revolutionary Eye Cancer Treatment

(Date:8/27/2014)... Top10BestSEOHosting.com compares many popular hosting suppliers and announces ... suppliers for webmasters who want to buy high ... provide stellar hosting products and services for worldwide ... provide a wide range of advanced features while ... helps diminish the inherent complexity and learning curve ...
(Date:8/27/2014)... Ontario, Canada (PRWEB) August 27, 2014 ... a huge transformation as was revealed in a survey ... survey were not just surprising but astonishing as well, ... carried out online interviewed existing members on the 10yeargap ... , According to Kaly, 10yeargap marketing department manager," there ...
(Date:8/27/2014)... Houston, TX (PRWEB) August 27, 2014 ... field of personal and corporate transformation through their comprehensive ... Training, Barb Moses has unparalleled experience in the realm ... to share this expertise in a new webinar series ... a Best Seller.” The first of this two part ...
(Date:8/27/2014)... New York, NY (PRWEB) August 27, 2014 ... arrogant failure, he finally found his niche. The Women’s Radio ... KC Armstrong for his continued support and dedication to the ... to be able to have such a positive atmosphere.” After ... producers on Sirius XM of the Howard Stern show, “Howard ...
(Date:8/27/2014)... Casey Diekman, assistant professor of mathematical sciences at New ... greater insight into the biological clock that sets the ... behavior of humans and all other mammals with fundamental ... and dark experienced each day and with seasonal change. ... natural patterns of sleep/wake behavior which, when disrupted by ...
Breaking Medicine News(10 mins):Health News:Excellent Hosting Suppliers Recommended By Top10BestSEOHosting.com 2Health News:Survey Reveals Younger Women Dating Older Men 2Health News:Survey Reveals Younger Women Dating Older Men 3Health News:Barb Moses, Vice President of Discover Leadership Training, Announces New Webinar Titled, “A Women’s Guide to Making Her Life Story a Bestseller” 2Health News:The Women's Radio Network, WRNW1, Signs KC Armstrong to a Multi-Million Dollar Contract 2Health News:NJIT Researcher Receives New NSF Funding to Study Fundamental Rhythms of Life 2Health News:NJIT Researcher Receives New NSF Funding to Study Fundamental Rhythms of Life 3Health News:NJIT Researcher Receives New NSF Funding to Study Fundamental Rhythms of Life 4
... treatment, study finds , MONDAY, Jan. 25 (HealthDay News) ... are given an electrocardiogram by paramedics before reaching the ... open their arteries. , They often were able to ... cardiac catheterization laboratory for treatment with what,s commonly known ...
... than county hospitals, research shows , MONDAY, Jan. 25 ... prostate cancer patients is influenced by the kind of ... U.S. study has found. , Surgery was more common ... in private facilities were more likely to undergo radiation ...
... , , HOUSTON ... of the AcceleDent System , which is an acceleration ... engaged Waldemar "Val" B. Szwajkowski as an advisor ... primarily focused on strategic development of key markets, and alignment ...
... Announces Special 1199 Fundraising Drive For UNICEF, Volunteer Recruitment efforts; Launches ... NEW YORK , Jan. 25 1199 SEIU ... the country - today announced that it is donating $1 ... and recovery efforts in Haiti .  In doing so, the ...
... by health economists at the University of York has raised ... and economic benefits considered in the analysis of new NHS ... Economics suggests that widening the perspective used by the National ... cost-effectiveness of new technologies may not benefit either the NHS ...
... infections, genetics and the environment are complex and mysterious. ... to autoimmune diseases like rheumatoid arthritis and lupus? How ... disease? Our immediate environment interacts with our genetic ... an autoimmune disease, says rheumatologist Prof. Michael Ehrenfeld of ...
Cached Medicine News:Health News:Prostate Cancer Care Varies By Hospital Type 2Health News:Industry Advisor Joins OrthoAccel Technologies, Inc. 2Health News:Industry Advisor Joins OrthoAccel Technologies, Inc. 3Health News:Industry Advisor Joins OrthoAccel Technologies, Inc. 4Health News:1199 SEIU United Healthcare Workers East Donates $1 Million to UNICEF for Haiti Earthquake Emergency Relief 2Health News:1199 SEIU United Healthcare Workers East Donates $1 Million to UNICEF for Haiti Earthquake Emergency Relief 3Health News:1199 SEIU United Healthcare Workers East Donates $1 Million to UNICEF for Haiti Earthquake Emergency Relief 4Health News:The NHS and the cost-benefit dilemma 2Health News:How arthritis thrives 2
(Date:8/26/2014)... 26, 2014 BioMed Realty Trust, Inc. (NYSE: ... a new lease with GlycoMimetics, Inc. (NASDAQ: ... feet at the Center for Life Science | Shady ... is a clinical-stage biotechnology company focused on the discovery ... an understanding of the role of carbohydrates in important ...
(Date:8/26/2014)... -- Research and Markets has announced the ... 2014 " report to their offering. ... a professional and in-depth study on the current state ... report provides a basic overview of the industry including ... meter market analysis is provided for both the international ...
(Date:8/26/2014)... BLUE BELL, Pa. , Aug. 26, 2014 ... PRA Health Sciences, largest office worldwide. PRA, a leading global Contract ... and Fort Washington locations into ... . The new office opened this week and marks the ... an exciting time for us at PRA," said Harris Koffer ...
Breaking Medicine Technology:BioMed Realty Signs New Lease With GlycoMimetics At Its Newly Redeveloped Center For Life Science | Shady Grove Campus In Rockville, Maryland 2BioMed Realty Signs New Lease With GlycoMimetics At Its Newly Redeveloped Center For Life Science | Shady Grove Campus In Rockville, Maryland 3Global Glucose Meter Industry Report 2014 2Global Glucose Meter Industry Report 2014 3PRA Health Sciences Expands in Pennsylvania 2
... -Triggers $5 Million Payment from Roche- , ... Corp. (Nasdaq: MEMY ) today announced that it ... of R3487/MEM 3454, its lead alpha-7 nicotinic receptor agonist, in ... randomized 212 patients in the Phase 2 trial, triggering a ...
... underscores that mothers need to get families immunized against influenza; ... , WASHINGTON, Nov. 18 ... influenza a severe and potentially life-threatening disease that can strike ... get vaccinated this season, according to a new survey from ...
Cached Medicine Technology:Memory Pharmaceuticals Achieves Enrollment Goal for Phase 2 Study of MEM 3454 in Cognitive Impairment Associated With Schizophrenia 2Memory Pharmaceuticals Achieves Enrollment Goal for Phase 2 Study of MEM 3454 in Cognitive Impairment Associated With Schizophrenia 3Video: New Survey Finds Mothers See Influenza as a Serious Health Threat, but Often Don't Get Their Families Vaccinated 2Video: New Survey Finds Mothers See Influenza as a Serious Health Threat, but Often Don't Get Their Families Vaccinated 3Video: New Survey Finds Mothers See Influenza as a Serious Health Threat, but Often Don't Get Their Families Vaccinated 4Video: New Survey Finds Mothers See Influenza as a Serious Health Threat, but Often Don't Get Their Families Vaccinated 5Video: New Survey Finds Mothers See Influenza as a Serious Health Threat, but Often Don't Get Their Families Vaccinated 6
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: