Navigation Links
Resistant tumors could be treated with the discovery of a new molecule within cancer cells

A new research study published in the journal, Cancer Cell reported that scientists have discovered why some tumors respond less well to drug treatment as compared to others. Researchers have found that high levels of a specific molecule within cancer cells seem to block the effect of drugs such as Taxol, which are used to treat a number of cancers in their later stages. In the study, the// researchers focused on a molecule called AURORA-A which is found at higher than normal levels in up to half of breast and bowel tumors, and in many other kinds of cancer. They genetically engineered cervical cancer cells with the gene for AURORA-A in order to increase levels of the molecule. They found that when treated with Taxol only about half as many engineered cells were killed by the drug as non-engineered cells.

In normal cell division, a cell can only divide if it has correctly shared out all its genes, ensuring each new cell receives a complete set. If there is a problem with the process of sharing out genes, an alarm will be triggered and the cell will not divide. However, cells with high amounts of AURORA-A seemed to over-ride the alarm and continue to divide, even when their genes were not correctly shared out. This ability to ignore the alarm could make them resistant to Taxol-type drugs. Lead researcher, Ashok Venkitaraman said that high amounts of AURORA-A seemed to make cancer cells less sensitive to treatment and a new test to look for the molecules in the tumor to predict how effective Taxol treatment is likely to be. The findings that are yet to be confirmed in cancer patients, raises the additional possibility that new drugs which inactivate the molecule could boost the response of cancer cells to treatment.


'"/>




Page: 1

Related medicine news :

1. Hope for Chemo-Resistant Leukemia Patients
2. Understanding Gene Profiles Could Help Cure A Resistant Form Of Leukemia In Kids
3. HIV Virus Emerging Drug Resistant In UK, Prompting Fear Of A Second Epidemic
4. 90 Million Americans Harbor Drug Resistant Bacteria Inside Their Nose
5. Resistant Influenza strains creates panic in US
6. Treatment Resistant Tumors Can Be Targeted Better Using Botox
7. New Drug Promises Hope In Multiple Drug Resistant And Latent TB Treatment
8. ‘Drug Resistant TB’ Rattles the Union Ministy
9. Malaria Resistant Mosquitoes Could Help In Combating Malaria
10. Tumor Resistant Mice Point To Novel Cancer Treatments
11. Mad-Cow Resistant Calf Cloned in China
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)... ... 23, 2017 , ... PreCheck, Inc., a background screening and ... with a three-year sales growth of 49 percent . The Inc. 5000 is ... comprehensive look at America’s independent entrepreneurs. This represents PreCheck’s fifth consecutive entry on ...
(Date:8/23/2017)... ... 23, 2017 , ... Silicon Valley Hair Institute, a leading San Francisco Bay ... The new rotation of archived blog posts can provide a wide selection of topics ... transplantation can review details online and then reach out for a no obligation consultation. ...
(Date:8/22/2017)... FRANCISCO BAY AREA, CA (PRWEB) , ... August ... ... premier, Nuvesse, an accessible luxurious collection of unique masks and serums that perfectly ... in scientific skin care advancements, at the 2017 Indie Beauty Expo on August ...
(Date:8/22/2017)... ... 22, 2017 , ... Each of the past six years, Lightning Labels has sent out a ... and stickers, demonstrating the variety and creativity of their designs. Submissions this year were open ... Now, it's time to announce the winners of the sixth annual Photo Contest, along with ...
(Date:8/22/2017)... ... ... “Wilderness Voices”: a collection of poetry inspired by life on a Kentucky farm ... author, Martha McKown, an ordained United Methodist minister with graduate degrees in Religious Education ... older sisters studied High School literature. She loved the early English folk ballads, ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), a ... of Directors has approved the payment of a quarterly cash ... The cash dividend of $0.24 ... 2017 to stockholders of record as of the close of ... subject to approval of the Board of Directors and may ...
(Date:8/4/2017)... -- The search for test results that can be ... long been the goal of healthcare providers and the ... largest meeting of lab professionals and IVD firms this ... Kalorama Information.  The firm said scores of companies with ... and software were at the American Association for Clinical ...
(Date:8/2/2017)... and BENTON, Ky. , Aug. 2, 2017   Marshall County Hospital ... environmental services (ES) team to proactively reduce the risk of hospital-acquired infections (HAIs). The new ... robot that uses UVC light energy to kill deadly pathogens such as C. diff ... Tru-D SmartUVC ... Tru-D in action in a ...
Breaking Medicine Technology: