Navigation Links
Resistant tumors could be treated with the discovery of a new molecule within cancer cells

A new research study published in the journal, Cancer Cell reported that scientists have discovered why some tumors respond less well to drug treatment as compared to others. Researchers have found that high levels of a specific molecule within cancer cells seem to block the effect of drugs such as Taxol, which are used to treat a number of cancers in their later stages. In the study, the// researchers focused on a molecule called AURORA-A which is found at higher than normal levels in up to half of breast and bowel tumors, and in many other kinds of cancer. They genetically engineered cervical cancer cells with the gene for AURORA-A in order to increase levels of the molecule. They found that when treated with Taxol only about half as many engineered cells were killed by the drug as non-engineered cells.

In normal cell division, a cell can only divide if it has correctly shared out all its genes, ensuring each new cell receives a complete set. If there is a problem with the process of sharing out genes, an alarm will be triggered and the cell will not divide. However, cells with high amounts of AURORA-A seemed to over-ride the alarm and continue to divide, even when their genes were not correctly shared out. This ability to ignore the alarm could make them resistant to Taxol-type drugs. Lead researcher, Ashok Venkitaraman said that high amounts of AURORA-A seemed to make cancer cells less sensitive to treatment and a new test to look for the molecules in the tumor to predict how effective Taxol treatment is likely to be. The findings that are yet to be confirmed in cancer patients, raises the additional possibility that new drugs which inactivate the molecule could boost the response of cancer cells to treatment.


'"/>




Page: 1

Related medicine news :

1. Hope for Chemo-Resistant Leukemia Patients
2. Understanding Gene Profiles Could Help Cure A Resistant Form Of Leukemia In Kids
3. HIV Virus Emerging Drug Resistant In UK, Prompting Fear Of A Second Epidemic
4. 90 Million Americans Harbor Drug Resistant Bacteria Inside Their Nose
5. Resistant Influenza strains creates panic in US
6. Treatment Resistant Tumors Can Be Targeted Better Using Botox
7. New Drug Promises Hope In Multiple Drug Resistant And Latent TB Treatment
8. ‘Drug Resistant TB’ Rattles the Union Ministy
9. Malaria Resistant Mosquitoes Could Help In Combating Malaria
10. Tumor Resistant Mice Point To Novel Cancer Treatments
11. Mad-Cow Resistant Calf Cloned in China
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the ... (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, ... Global Forecast to 2021" report to their offering. ... pharmaceutical excipients market is projected to reach USD 8.1 ... the forecast period 2016 to 2021. ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
Breaking Medicine Technology: